The central role of renal microcirculatory dysfunction in the pathogenesis of acute kidney injury [0.03%]
肾微循环障碍在急性肾脏损伤发病机制中的中心作用
Can Ince
Can Ince
Acute kidney injury (AKI) is a rapidly developing condition often associated with critical illness, with a high degree of morbidity and mortality, whose pathophysiology is ill understood. Recent investigations have identified the dysfunctio...
Regulation of TLR2 and NLRP3 in primary murine renal tubular epithelial cells [0.03%]
小鼠原代肾系膜细胞中TLR2和NLRP3的调节
Sashi G Kasimsetty,Sean E DeWolf,Alana A Shigeoka et al.
Sashi G Kasimsetty et al.
Pattern recognition receptors (PRRs) are now recognized to be key triggers of injury in a variety of renal diseases. Several families of these receptors are present in the kidney, and recent data suggest that they are differentially express...
Changing paradigms in acute kidney injury: from mechanisms to management--proceedings of the 5th annual UAB-UCSD O'Brien Center Symposium (San Diego, Calif., USA, March 4, 2014) [0.03%]
急性肾损伤研究范式的转变：从机制研究到临床实践——UAB-UCSD O'Brien中心第5届年度研讨会纪要（美国加利福尼亚州圣迭戈，2014年3月4日）
Ravindra L Mehta,Paul W Sanders,Anupam Agarwal
Ravindra L Mehta
Kathleen D Liu
Kathleen D Liu
Although at present we have developed consensus definitions for acute kidney injury (AKI) and there is a major focus on the treatment and prevention of AKI in high-risk populations, little is known about renal recovery per se and the impact...
Aneley Hundae,Peter A McCullough
Aneley Hundae
In recent years, there has been considerable interest in cellular and tissue responses to injury that result in the deposition of extracellular matrix, collagen, elastic fibers, and the histopathological development of fibrosis. In the myoc...
Zoltán H Endre
Zoltán H Endre
Establishing the prognosis for recovery has enormous clinical implications. The appropriate definition of renal recovery depends on the stage of acute kidney injury (AKI). As definitions of AKI have broadened to encompass small increases in...
Aashish Sharma,Marìa Jimena Mucino,Claudio Ronco
Aashish Sharma
Renal functional reserve (RFR) represents the capacity of the kidney to increase glomerular filtration rate (GFR) in response to certain physiological or pathological stimuli or conditions. Once baseline GFR is determined, RFR can be assess...
Frederic T Billings th,Andrew D Shaw
Frederic T Billings th
The development and use of consensus criteria for acute kidney injury (AKI) diagnosis and the inclusion of recently identified markers of renal parenchymal damage as endpoints in clinical trials have improved the ability of physicians to co...
How can we define recovery after acute kidney injury? Considerations from epidemiology and clinical trial design [0.03%]
急性肾损伤后的康复如何定义？流行病学和临床试验设计中的考虑因素
John A Kellum
John A Kellum
The recent recognition that acute kidney injury (AKI) may lead to the development of chronic kidney disease and end-stage renal disease, with the attendant increase in mortality, has led to interest in the clinical epidemiology and the mech...
Susanne V Fleig,Benjamin D Humphreys
Susanne V Fleig
Hundreds of clinical trials are currently investigating the potential for mesenchymal stem cells (MSC) to treat human disease, including kidney disease. There is tremendous excitement over the therapeutic potential of this form of stem cell...