Prasad Devarajan,Patrick Murray
Prasad Devarajan
Novel biomarkers are required to improve the timely detection of early acute kidney injury (AKI) and to improve the differential diagnosis, prognostic assessment, and management of AKI cases. It is anticipated that novel biomarkers of early...
Francesco Garzotto,Monica Zanella,Claudio Ronco
Francesco Garzotto
The provision of continuous renal replacement therapies (CRRT) to small children has generally required the adaptation of adult machines and modified operational characteristics. CRRT prescription for younger and smaller children versus adu...
Timothy Ball,Peter A McCullough
Timothy Ball
Acute kidney injury (AKI) is a common medical problem, especially in patients undergoing cardiovascular procedures. The risk of kidney damage has multiple determinants and is often related to or exacerbated by intravenous or intra-arterial ...
Focus on lipids: high-density lipoprotein cholesterol and its associated lipoproteins in cardiac and renal disease [0.03%]
脂质聚焦：心脏和肾脏疾病中的高密度脂蛋白胆固醇及其相关脂蛋白
Hyun Joon Shin,Peter A McCullough
Hyun Joon Shin
High-density lipoprotein cholesterol (HDL-C) contains dozens of apoproteins that participate in normal cholesterol metabolism with a reliance on renal catabolism for clearance from the body. The plasma pool of HDL-C has been an excellent in...
The spleen: the forgotten organ in acute kidney injury of critical illness [0.03%]
急性重症肾脏损伤中的被遗忘的器官——脾脏
Joseph C Gigliotti,Mark D Okusa
Joseph C Gigliotti
Acute kidney injury (AKI) is an increasing medical burden and is independently associated with mortality. AKI is a common comorbidity in the intensive care unit (ICU), with sepsis-associated AKI seen in almost a quarter of all ICU patients....
Role of renal oxygenation and mitochondrial function in the pathophysiology of acute kidney injury [0.03%]
肾氧合和线粒体功能在急性肾脏损伤病理生理中的作用
Noureddin Nourbakhsh,Prabhleen Singh
Noureddin Nourbakhsh
There are unique features of renal oxygenation that render the kidney susceptible to oxygen demand-supply mismatch and hypoxia. Renal oxygen consumption by oxidative metabolism is closely coupled to and driven by tubular transport, which is...
The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury [0.03%]
碱性磷酸酶在治疗脓毒症相关急性肾损伤中的潜力
Esther Peters,Rosalinde Masereeuw,Peter Pickkers
Esther Peters
Sepsis-associated acute kidney injury (AKI) is associated with a high attributable mortality and an increased risk of developing chronic kidney failure in survivors. As a successful therapy is, as yet, unavailable, a pharmacological treatme...
Intestinal microbiota-kidney cross talk in acute kidney injury and chronic kidney disease [0.03%]
肠道菌群-肾脏在急性肾损伤和慢性肾脏病中的相互作用
Sanjeev Noel,Maria N Martina-Lingua,Samatha Bandapalle et al.
Sanjeev Noel et al.
The pathophysiology of acute kidney injury (AKI) involves multiple and overlapping immunological, biochemical, and hemodynamic mechanisms that modulate the effects of both the initial insult and the subsequent repair. Limited but recent exp...
Do tubular changes in the diabetic kidney affect the susceptibility to acute kidney injury? [0.03%]
糖尿病肾病的管状变化会影响急性肾脏损伤的易感性吗？
Volker Vallon
Volker Vallon
Diabetes is the single largest contributor to the growing prevalence of chronic kidney disease (CKD), and episodes of acute kidney injury (AKI) increase the risk of advanced CKD in diabetic patients. Here we discuss whether the pathophysiol...
Renal cortical pyruvate as a potentially critical mediator of acute kidney injury [0.03%]
肾皮质乳酸在急性肾损伤中的作用
Ali C M Johnson,Richard A Zager
Ali C M Johnson
Pyruvate is a key intermediary in both aerobic and anaerobic energy metabolisms. In addition, a burgeoning body of experimental literature indicates that it can also dramatically impact oxidant, proinflammatory, and cytoprotective pathways....