Clinical implementation of intensity modulated proton therapy for testicular seminoma [0.03%]
强度调制质子治疗睾丸精原细胞瘤的临床应用
Heidi S Rønde,Jesper F Kallehauge,Morten Høyer et al.
Heidi S Rønde et al.
Background and purpose: We have previously shown that proton therapy results in considerable reduced doses to abdominal organs at risk (OAR) which likely reduces the patient's risk of a second malignant tumor, which is vi...
CNN-based prediction using early post-radiotherapy MRI as a proxy for toxicity in the murine head and neck [0.03%]
基于CNN的预测：早期放疗后MRI作为小鼠头颈部毒性的替代指标
Bao Ngoc Huynh,Manish Kakar,Olga Zlygosteva et al.
Bao Ngoc Huynh et al.
Background and purpose: Radiotherapy (RT) of head and neck cancer can cause severe toxicities. Early identification of individuals at risk could enable personalized treatment. This study evaluated whether convolutional ne...
Predictive factors of oral mucositis in patients with locally recurrent inoperable head and neck cancer treated with boron neutron capture therapy [0.03%]
硼中子俘获治疗复发性局部晚期头颈部肿瘤患者口腔黏膜炎的预后因素分析
Tanja Mälkiä,Hanna Koivunoro,Tiina Seppälä et al.
Tanja Mälkiä et al.
Background and purpose: The prognosis of recurrent head and neck (HN) cancer is poor. High response rates have been achieved with boron neutron capture therapy (BNCT) in the treatment of locally recurrent HN cancer. Radia...
Complete remission with olaparib in BRIP1-mutated metastatic high-grade pleomorphic sarcoma: case study and literature review - an example of a genomic profiling-based tumor treatment, in a cancer type with high unmet clinical need [0.03%]
奥拉帕利治疗BRIP1突变型高度恶性多形性肉瘤的完全缓解：病例研究与文献回顾——基于基因组谱分析的肿瘤治疗，可满足临床需求较高的癌症类型的一个范例
Alexander D J Thooft,Sofie Joris,Celine Jacobs et al.
Alexander D J Thooft et al.
Background and purpose: Patients with high-grade metastatic sarcoma have a poor prognosis and limi-ted treatment options, mostly involving chemotherapy with palliative intent. In the past years, next generation sequencing...
Model-based trends in the estimated number of children affected by maternal cancer diagnosis or death in Finland in 1968-2022 [0.03%]
1968-2022年芬兰估计受母亲癌症诊断或死亡影响的儿童数量的趋势（基于模型）
Kirsi M Talala,Eetu E Mäkinen,Karri J M Seppä et al.
Kirsi M Talala et al.
Background and purpose: Cancer is among the leading causes of premature death worldwide, and, in Finland, it is the most common cause of death among women aged 15-64 years who may be parenting minor children. We aim to es...
Dosimetric impact of esophageal motion in esophagus-sparing radiotherapy of spinal metastases [0.03%]
脊柱转移瘤食管避让放射治疗中食管运动的剂量学影响
Anna Mann Nielsen,Laura Ann Rechner,Sebastian Moretto Krog et al.
Anna Mann Nielsen et al.
Background and purpose: The phase III trial (NCT05109819) investigates whether esophagus-sparing radiotherapy (RT) reduces dysphagia in patients with spinal metastases. This retrospective simulation study evaluates the do...
Pembrolizumab as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma: a multi-institutional DAHANCA cohort study [0.03%]
帕博利尤单抗作为复发或转移性头颈部鳞状细胞癌一线治疗的多机构DAHANCA队列研究
Sebastian Søby,Robin Prestwich,Niels Gyldenkerne et al.
Sebastian Søby et al.
Background and purpose: Pembrolizumab is frequently used for recurrent or metastatic head and neck squamous cell carcinoma (rmHNSCC) as first-line treatment. This study evaluates real-world effectiveness in a Danish and U...
Late dysphagia after changes in high-dose clinical tumour volume margin for head and neck cancer patients [0.03%]
头颈部癌症患者高剂量临床肿瘤体积边缘变化后的晚期吞咽困难
Ruta Zukauskaite,Jesper Grau Eriksen,Jørgen Johansen et al.
Ruta Zukauskaite et al.
Background and purpose: One of the factors influencing disease control and toxicity risk after radiotherapy is selection of treatment volume margin. This study evaluates whether different gross tumour volume (GTV) to high...
Impact of GTV-CTV margin and other predictors on radiation-induced dysphagia in head and neck cancer patients from DAHANCA group [0.03%]
丹麦DAHANCA协作组头颈癌患者靶区扩大边界及放疗致吞咽困难的预测因素分析
Sarah Wordenskjold Stougaard,Ruta Zukauskaite,Richard Röttger et al.
Sarah Wordenskjold Stougaard et al.
Background and purpose: This multicentre, retrospective study aimed to develop a predictive model for radiation-induced dysphagia in head and neck cancer patients, focusing on the role of gross tumour volume (GTV) to high...
Impact of radiation dose on neurocognitive function and quality of life in long-term survivors of childhood brain tumour [0.03%]
剂量对儿童脑瘤长期生存者神经认知功能和生活质量的影响
Laura Toussaint,Anne Sophie Lind Helligsø,Ludvig Paul Muren et al.
Laura Toussaint et al.
Background and purpose: Children treated with radiotherapy (RT) for a brain tumour often exhibit neurocognitive impairment and report lower quality of life (QoL) later in life. The aim of this nationwide cross-sectional c...