Geng Qin,Chuanqi Zhao,Jie Yang et al.
Geng Qin et al.
The applicability of G-quadruplexes (G4s) as antiviral targets, therapeutic agents and diagnostic tools for coronavirus disease 2019 (COVID-19) is currently being evaluated, which has drawn the extensive attention of the scientific communit...
Tzu-Yu Chen,Jinfeng Chen,Yijie Tang et al.
Tzu-Yu Chen et al.
Isonitrile group has been identified in many natural products. Due to the broad reactivity of N≡C triple bond, these natural products have valuable pharmaceutical potentials. This review summarizes the current biosynthetic pathways and the...
Order from Chaos: Self-Assembly of Nanoprism from a Mixture of Tetratopic Terpyridine-Porphyrin Conformers [0.03%]
从四臂互变异构体混合物自组装形成纳米棱镜：从混沌到有序
Alexander Filosa,Heng Wang,Wei-Jian Li et al.
Alexander Filosa et al.
Porphyrins have been widely used in the self-assembly of metallo-supramolecules. In this study, we introduced 2,2':6,2"-terpyridine (tpy) into a porphyrin core to synthesize a tetratopic building block with multiple conformers. During the s...
Synthesis and Biological Evaluation of Quinolinone Compounds as SARS CoV 3CLpro Inhibitors [0.03%]
作为SARS冠状病毒3CL蛋白酶抑制剂的喹诺酮化合物的合成与生物活性评价
Yuanpei Sun,Ning Zhang,Jian Wang et al.
Yuanpei Sun et al.
SARS CoV 3CLpro is known to be a promising target for development of therapeutic agents against the severe acute respiratory syndrome (SARS). A quinolinone compound 1 was selected via virtual screening, and it was synthetized and tested for...
Discovery of anti-SARS coronavirus drug based on molecular docking and database screening [0.03%]
基于分子对接和数据库筛选的抗SARS冠状病毒药物发现
Hai-Feng Chen,Jian-Hua Yao,Jing Sun et al.
Hai-Feng Chen et al.
The active site of 3CL proteinase (3CLpro) for coronavirus was identified by comparing the crystal structures of human and porcine coronavirus. The inhibitor of the main protein of rhinovirus (Ag7088) could bind with 3CLpro of human coronav...
Asymmetric carbonyl addition with the homochiral ketimine derived from (+) or (−)-pinanone and benzylamine [0.03%]
由（+）或（-）-蒎烷酮和苄胺衍生的高手性酮亚胺的不对称羰基加成反应
Ai-Qiao Mi; Yuan-Wei Chen; Jing Wang; Gui-Shu Yang; Yao-Zhong Jiang
Ai-Qiao Mi; Yuan-Wei Chen; Jing Wang; Gui-Shu Yang; Yao-Zhong Jiang
Separation mechanism of chiral compounds in chiral stationary phase liquid chromatography [0.03%]
手性固定相液相色谱中手性化合物的分离机理
Han-Fa Zou; Yu-Kui Zhang; Pei-Chang Lu
Han-Fa Zou; Yu-Kui Zhang; Pei-Chang Lu
Photoaddition of chloroform to ketones via a singlet exciplex: A photo-CIDNP study [0.03%]
通过单线态激基复合物将氯仿光加成到酮中：光CIDNP研究
Mao-Xi Zhang; Li Yang; Zhong-Li Liu; You-Cheng Liu
Mao-Xi Zhang; Li Yang; Zhong-Li Liu; You-Cheng Liu
Wu Dong-Hui; Shen Lian-Fang; Xue Guo-Pin; Wu Cheng-Tai
Wu Dong-Hui; Shen Lian-Fang; Xue Guo-Pin; Wu Cheng-Tai
Lan Jin; Pin Yang
Lan Jin; Pin Yang