Alicia J Jenkins,Mugdha V Joglekar,Anandwardhan A Hardikar et al.
Alicia J Jenkins et al.
There is a global diabetes epidemic correlating with an increase in obesity. This coincidence may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained increase in the incidence of type 1 diabetes, which i...
Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy [0.03%]
糖尿病肾病中针对线粒体和活性氧驱动的发病机制治疗
Runa Lindblom,Gavin Higgins,Melinda Coughlan et al.
Runa Lindblom et al.
Diabetic kidney disease is one of the major microvascular complications of both type 1 and type 2 diabetes mellitus. Approximately 30% of patients with diabetes experience renal complications. Current clinical therapies can only mitigate th...
Evangelia Dounousi,Anila Duni,Konstantinos Leivaditis et al.
Evangelia Dounousi et al.
The burden of diabetes mellitus is relentlessly increasing. Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD) worldwide and a major cause of morbidity and mortality in patients with diabetes. The current standa...
Konstantinos Tziomalos,Vasilios G Athyros
Konstantinos Tziomalos
Diabetic nephropathy is the leading cause of end-stage renal disease. Patients with diabetic nephropathy have a high cardiovascular risk, comparable to patients with coronary heart disease. Accordingly, identification and management of risk...
Giorgina B Piccoli,Giorgio Grassi,Gianfranca Cabiddu et al.
Giorgina B Piccoli et al.
The term "diabetic kidney" has recently been proposed to encompass the various lesions, involving all kidney structures that characterize protean kidney damage in patients with diabetes. While glomerular diseases may follow the stepwise pro...
Treating Diabetic Neuropathy: Present Strategies and Emerging Solutions [0.03%]
糖尿病神经病变的治疗：现有策略和新兴解决方案
Saad Javed,Uazman Alam,Rayaz A Malik
Saad Javed
Diabetic peripheral neuropathies (DPN) are a heterogeneous group of disorders caused by neuronal dysfunction in patients with diabetes. They have differing clinical courses, distributions, fiber involvement (large or small), and pathophysio...
Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015 [0.03%]
糖尿病性神经病变的危险因素和并存病（2015年更新）
Nikolaos Papanas,Dan Ziegler
Nikolaos Papanas
Distal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia...
Prashanth R J Vas,Sanjeev Sharma,Gerry Rayman
Prashanth R J Vas
Neurological complications of diabetes are common, affecting up to 50% of people with diabetes. In these patients, diabetic sensorimotor neuropathy (DSPN) is by far the most frequent complication. Detecting DSPN has traditionally been a cli...
Vascular Impairment of Epineurial Arterioles of the Sciatic Nerve: Implications for Diabetic Peripheral Neuropathy [0.03%]
糖尿病外周神经病变的坐骨神经表被动脉血管损伤的可能作用
Mark A Yorek
Mark A Yorek
This article reviews the impact of diabetes and its treatment on vascular function with a focus on the reactivity of epineurial arterioles, blood vessels that provide circulation to the sciatic nerve. Another focus is the relationship betwe...
High Recovery of Functional Islets Stored at Low and Ultralow Temperatures [0.03%]
低温和超低温储存的胰岛细胞的功能恢复率达高标
Bhawna Chandravanshi,Anandh Dhanushkodi,Ramesh Bhonde
Bhawna Chandravanshi
Background: Poor recovery of islets upon cryopreservation is the main hurdle in islet banking. Pancreatic islets have a poor antioxidative defense mechanism, and exposure of islets to low temperature leads to oxidative st...