Pancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine Pancreas [0.03%]
糖尿病和正常生理条件下的胰腺体积及脂肪浸润：内分泌与外分泌胰腺相互作用的考量
Yoshifumi Saisho
Yoshifumi Saisho
The pancreas is comprised of exocrine and endocrine components. Despite the fact that they are derived from a common origin in utero, these two compartments are often studied individually because of the different roles and functions of the ...
The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes [0.03%]
蒲公英（Taraxacum officinale）对2型糖尿病生理影响的研究
Fonyuy E Wirngo,Max N Lambert,Per B Jeppesen
Fonyuy E Wirngo
The tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential anti-diabetic properties. T...
Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects [0.03%]
具有抗糖尿病效应的药用植物提取物的化学和生物学方面的问题
Lucas F Gushiken,Fernando P Beserra,Ariane L Rozza et al.
Lucas F Gushiken et al.
Diabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteris...
Esophageal and Gastric Dysmotilities are Associated with Altered Glucose Homeostasis and Plasma Levels of Incretins and Leptin [0.03%]
食管和胃排空障碍与糖代谢及胰岛素分泌促进肽和瘦素水平的改变有关
Rebecka Hammersjö,Bodil Roth,Peter Höglund et al.
Rebecka Hammersjö et al.
Background: Gastrointestinal complications in diabetes may affect glucose and endocrine homeostasis. Glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and leptin regulate glucose homeostasis...
Chronic Exposure to Proline Causes Aminoacidotoxicity and Impaired Beta-Cell Function: Studies In Vitro [0.03%]
脯氨酸的慢性暴露导致氨基酸毒性以及β细胞功能障碍：体内研究
Zhenping Liu,Per B Jeppesen,Søren Gregersen et al.
Zhenping Liu et al.
Background: Pancreatic islet-cell dysfunction is a hallmark in the development of diabetes, but the reasons for the primary β-cell defect are still elusive. Elevated circulating proline levels have been found in subjects...
Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion [0.03%]
通过确定生理表型来理解2型糖尿病中的遗传异质性：SIRT1及其基因网络在胰岛素分泌障碍中的作用
Shafat Ali,Shazia Nafis,Ponnusamy Kalaiarasan et al.
Shafat Ali et al.
Type 2 diabetes (T2D) is a chronic metabolic disease which shows an exponential increase in all parts of the world. However, the disease is controllable by early detection and modified lifestyle. A series of factors have been associated wit...
Macronutrient Composition and Management of Non-Insulin-Dependent Diabetes Mellitus (NIDDM): A New Paradigm for Individualized Nutritional Therapy in Diabetes Patients [0.03%]
非胰岛素依赖型糖尿病患者的营养治疗新模式：个体化治疗方案及营养管理措施
Efi Koloverou,Demosthenes B Panagiotakos
Efi Koloverou
Medical nutrition therapy constitutes an important lifestyle intervention in diabetes management. Several nutrition patterns have been effective in improving diabetes control, but there has been a debate about the optimal macronutrient comp...
Harald Staiger,Elke Schaeffeler,Matthias Schwab et al.
Harald Staiger et al.
Many clinical treatment studies have reported remarkable interindividual variability in the response to pharmaceutical drugs, and uncovered the existence of inadequate treatment response, non-response, and even adverse drug reactions. Pharm...
Aaron Leong,James B Meigs
Aaron Leong
Hemoglobin A1c (HbA1c) is a biomarker used for population-level screening of type 2 diabetes (T2D) and risk stratification. Large-scale, genome-wide association studies have identified multiple genomic loci influencing HbA1c. We discuss the...
When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes [0.03%]
当心MODY！解读MODY基因序列变异的挑战
Sara Althari,Anna L Gloyn
Sara Althari
The genomics revolution has raised more questions than it has provided answers. Big data from large population-scale resequencing studies are increasingly deconstructing classic notions of Mendelian disease genetics, which support a simplis...