Autoimmune diabetes: ongoing development of immunological intervention strategies targeted directly against autoreactive T cells [0.03%]
自身免疫性糖尿病：针对自身反应性T细胞的免疫干预策略的持续开发
Charles Sia
Charles Sia
It is well known that autoimmunity associated with the onset of insulin-dependent diabetes mellitus (IDDM) involves the generation of autoreactive T and B cells. The findings that diabetics mount humoral and cellular immune responses agains...
Type 2 diabetes mellitus and its complications: from the molecular biology to the clinical practice [0.03%]
2型糖尿病及其并发症：从分子生物学至临床实践
Maciej T Malecki
Maciej T Malecki
Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison [0.03%]
免疫细胞内抗原处理途径中1型糖尿病的遗传易感性——主题评论与跨研究比较
Charles Sia,Michael Weinem
Charles Sia
Ligand binding grooves of MHC class I molecules are able to load a panel of endogenous peptides of varying length and sequence derived from self or foreign origin to activate or deactivate cytotoxic CD8(+) T cells. Peptides are assembled wi...
Type 2 Diabetes - failure, blame and guilt in the adoption of insulin therapy [0.03%]
2型糖尿病——胰岛素治疗采纳过程中的失败、责备和自责
Patrick Phillips
Patrick Phillips
Type 2 Diabetes is a progressive disease with an insidious onset, including decreased first-phase insulin secretion and mild forms of hyperinsulinemia caused by heterogenous factors such as genetic make-up, obesity and lifestyle. Decreased ...
Diabetes-induced fetal growth retardation is associated with suppression of NF-kappaB activity in embryos [0.03%]
糖尿病引起的胚胎生长迟缓与NF-κB活性抑制有关
Keren Mammon,Rotem Keshet,Shoshana Savion et al.
Keren Mammon et al.
Background: Mechanisms underlying diabetes-induced fetal growth retardation remain largely undefined. Two events such as the persistent activation of apoptosis or suppression of cell proliferation in embryos might directl...
Proteomic identification and immunolocalization of increased renal calbindin-D28k expression in OVE26 diabetic mice [0.03%]
蛋白质组学鉴定和增加的肾钙结合蛋白-D28k表达在OVE26糖尿病小鼠中的免疫定位
Visith Thongboonkerd,Shirong Zheng,Kenneth R McLeish et al.
Visith Thongboonkerd et al.
Diabetic nephropathy is a common diabetic complication that is associated with alterations in the expression of several renal proteins and abnormal calcium homeostasis. We performed proteomic analysis to screen for global changes of renal p...
The role of regulatory T cell defects in type I diabetes and the potential of these cells for therapy [0.03%]
调节性T细胞缺陷在1型糖尿病中的作用及其治疗潜力
David Thomas,Paola Zaccone,Anne Cooke
David Thomas
Type I diabetes is increasing in incidence in developed countries [1]. Diabetes arises from a breakdown of tolerance to islet antigens, resulting in T cell-driven destruction of the islet cells and concomitant hyperglycemia. In this review,...
The fate of Beta-cells in type 2 diabetes and the possible role of pharmacological interventions [0.03%]
2型糖尿病背景下β细胞的命运以及药物干预的可能作用
Baptist Gallwitz
Baptist Gallwitz
This article gives an overview of two recent trials investigating rosiglitazone, a thiazolidinedione, in its potential to prevent type 2 diabetes (T2D) and in its effectiveness in monotherapy. Thiazolidinediones are among the most important...
Maternally inherited diabetes with deafness and obesity: body weight reduction response to treatment with insulin analogues [0.03%]
母系遗传糖尿病伴聋病和肥胖：胰岛素类似物治疗的体重反应
Maciej T Malecki,Jan Skupien,Tomasz Klupa et al.
Maciej T Malecki et al.
Maternally inherited diabetes with deafness (MIDD) is a rare, monogenic form of diabetes mellitus caused by mutations in the mitochondrial genome, the most frequent being the A3243G substitution of the tRNA(Leu) gene. We screened 520 indivi...