Apoptosis in autoimmune diabetes: the fate of beta-cells in the cleft between life and death [0.03%]
自身免疫性糖尿病中的凋亡作用：β细胞在生存和死亡之间的命运
Charles Sia,Arno Hänninen
Charles Sia
Cytokine-induced beta-cell death is the end-stage event in the pathogenesis of autoimmune diabetes. Beside cytokines, several pro-apoptotic pathways mediated through nitric oxide, reactive oxygen species, glucose and Fas ligation can be inv...
The effect of PPARgamma-agonism on LDL subclass profile in patients with type 2 diabetes and coronary artery disease [0.03%]
PPARγ激动剂对2型糖尿病合并冠心病患者LDL亚型分布的影响
Riikka Lautamäki,Pirjo Nuutila,K E Juhani Airaksinen et al.
Riikka Lautamäki et al.
Patients with type 2 diabetes (T2DM) often present a preponderance of small, dense LDL particles (small-LDL), which are associated with a high risk of myocardial infarction. Some studies suggest that PPARgamma-agonists increase LDL choleste...
ENPP1 K121Q polymorphism is not related to type 2 diabetes mellitus, features of metabolic syndrome, and diabetic cardiovascular complications in a Chinese population [0.03%]
ENPP1K121Q多态性与我国汉族人群2型糖尿病及其心血管并发症无关
Miao-Pei Chen,Fu-Mei Chung,Dao-Ming Chang et al.
Miao-Pei Chen et al.
Background: Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is known to influence insulin sensitivity by inhibiting insulin receptor signaling. A DNA polymorphism in the ENPP1 gene at exon 4 (K121Q) was de...
Assessment of insulin sensitivity in adults with permanent neonatal diabetes mellitus due to mutations in the KCNJ11 gene encoding Kir6.2 [0.03%]
KCNJ11基因突变导致的永久性新生儿糖尿病成人患者胰岛素敏感性的评估
Jan Skupien,Maciej T Malecki,Wojciech Mlynarski et al.
Jan Skupien et al.
Activating mutations in the KCNJ11 gene encoding the Kir6.2 subunit of ATP-sensitive potassium channel have been described in patients with permanent neonatal diabetes mellitus (PNDM). The main pathophysiological feature of PNDM associated ...
Eating behavior among type 2 diabetic patients: a poorly recognized aspect in a poorly controlled disease [0.03%]
2型糖尿病患者中的进食行为：一种在控制不良的疾病中被忽视的现象
Mary Yannakoulia
Mary Yannakoulia
Nutrition intervention is an integral part of type 2 diabetes care. Dietary management entails a series of eating behavior changes regarding meal planning, food selection, food preparation, dining out, portion control, as well as appropriat...
Deepak Yadav,Nora Sarvetnick
Deepak Yadav
T cell activation is a complex process that requires a multitude of interactions between antigen-presenting cells (APC) and T cells. The primary signal is provided via the binding of the antigen (Ag) presented by the major histocompatibilit...
Tolerance induction and endogenous regeneration of pancreatic beta-cells in established autoimmune diabetes [0.03%]
成熟自身免疫糖尿病的胰岛β细胞耐受诱导及内在再生
Charles Sia,Francoise Homo-Delarche
Charles Sia
Studies aimed at the understanding of the multifactorial development of autoimmune diabetes have made substantial contributions toward elucidating the molecular mechanisms that open the road to an effective prevention of defective immune re...
A case of acquired generalized lipodystrophy with cerebellar degeneration and type 2 diabetes mellitus [0.03%]
获得性全身性脂代谢障碍伴小脑退行变和2型糖尿病病例报告
Pei-Jiuan Chao,Jack C-R Tsai,Dao-Ming Chang et al.
Pei-Jiuan Chao et al.
Acquired generalized lipodystrophy (AGL) is a rare disorder of adipose tissue characterized by loss of fat from large regions of the body, occurring after birth. Its etiology remains unknown. Most AGL patients have had fasting and/or postpr...
Meghana Kanitkar,Ramesh Bhonde
Meghana Kanitkar
Reduction in the functional mass of beta-cells is a common denominator in most forms of diabetes. Since the replicative potential of beta-cells is limited, the search for factors that trigger islet neogenesis becomes imperative. Here we tes...
Differential postprandial lipoprotein responses in type 2 diabetic men with and without clinical evidence of a former myocardial infarction [0.03%]
2型糖尿病患者和有无心肌梗死史的血脂响应差异性研究
Marius Carstensen,Claus Thomsen,Ole Gotzsche et al.
Marius Carstensen et al.
Postprandial lipemia plays an important role in the development of coronary heart disease through an elevation of triglyceride-rich lipoproteins. In type 2 diabetic male subjects, our aim was to compare postprandial lipemia in a high-risk p...