Impairment of skin capillary recruitment precedes chronic complications in patients with type 1 diabetes [0.03%]
1型糖尿病患者皮肤毛细血管募集功能障碍先于慢性并发症出现
Eduardo Tibirica,Elba Rodrigues,Roberta Cobas et al.
Eduardo Tibirica et al.
Microvascular function in patients with type 1 diabetes without chronic complications was assessed using skin capillary recruitment during post-occlusive reactive hyperemia (PORH). Structural (maximal) capillary density was evaluated during...
Congenital and environmental factors associated with adipocyte dysregulation as defects of insulin resistance [0.03%]
与脂肪细胞失调相关的先天性和环境因素作为胰岛素抵抗缺陷分析
Chao-Ping Wang,Fu-Mei Chung,Shyi-Jang Shin et al.
Chao-Ping Wang et al.
The metabolic syndrome refers to insulin resistance and its associated cluster of related cardiovascular metabolic risk factors including type 2 diabetes, hypertension, dyslipidemia and central obesity. Although many hypotheses and facts ha...
The cross-regulatory relationship between human dendritic and regulatory T cells and its role in type 1 diabetes mellitus [0.03%]
人树突状细胞与调节性T细胞的交叉调控及其在1型糖尿病中的作用
Hsuen-Wen Chang,Yen-Hung Chow,Pele Chong et al.
Hsuen-Wen Chang et al.
Dendritic cells (DCs) and T regulatory (Treg) cells play a crucial role in maintaining the tolerance needed to prevent the onset of autoimmunity that leads to the development of type 1 diabetes mellitus (T1DM). Various experimental studies ...
The Development and Application of HLA Tetramers in the Detection, Characterization and Therapy of Type 1 Diabetes Mellitus [0.03%]
HLA四聚体在1型糖尿病检测、表征及治疗中的发展和应用
Hsin-Wei Chen,Shih-Jen Liu,Pele Chong et al.
Hsin-Wei Chen et al.
Islet antigens are presented by human leukocyte antigen (HLA) class I and II molecules and are recognized by CD8(+) and CD4(+) autoreactive T cells in type 1 diabetic individuals. Early identification of individuals at risk for the disease ...
Association of Resistin Gene 3'-Untranslated Region EX4-44G-->A Polymorphism with Obesity- and Insulin-Related Phenotypes in Turkish Type 2 Diabetes Patients [0.03%]
resistin基因3' untranslated region EX4-44 G>A多态性与土耳其2型糖尿病患者的肥胖及胰岛素相关表型的关联分析
Belgin Susleyici Duman,Penbe Cagatay,Husrev Hatemi et al.
Belgin Susleyici Duman et al.
Resistin, an adipocyte-secreted hormone, has been associated with obesity, insulin resistance and type 2 diabetes mellitus (T2DM) in some, but not all, rodent models. In humans, the exact function of resistin is unkown. Because 3'-untransla...
Improved Monitoring of the Hyperglycemic State in Type 1 Diabetes Patients by Use of the Glycoalbumin/HbA1c Ratio [0.03%]
glycA和HbA1c比值在1型糖尿病患者高血糖状态监测中的应用价值
Takatoshi Imai,Yoichi Oikawa,Akira Shimada
Takatoshi Imai
Aim: Generally, the level of glycoalbumin (GA) is approximately 3 times higher than that of HbA1c. However, in type 1 diabetic patients, we often find an even higher GA/HbA1c ratio of nearly 3.5. Therefore, this study was...
Bis(quercetinato)oxovanadium IV Reverses Metabolic Changes in Streptozotocin-Induced Diabetic Mice [0.03%]
四价氧钒双金雀花酸酯可逆转链脲佐菌素诱导的糖尿病小鼠的代谢变化
Ruchi Shukla,Subhash Padhye,Manisha Modak et al.
Ruchi Shukla et al.
Organic vanadium compounds offer several advantages in the treatment of diabetes, yet they are impractical to use because of known side effects. In order to ameliorate the side effects of vanadium, we conjugated it with quercetin to form bi...
Endoplasmic reticulum stress caused by overexpression of islet-specific glucose-6-phosphatase catalytic subunit-related protein in pancreatic Beta-cells [0.03%]
胰岛特异性葡萄糖六磷酸酶催化亚基相关蛋白在胰岛β细胞过表达所致的内质网应激反应
Afshin Shameli,Jun Yamanouchi,Shari Thiessen et al.
Afshin Shameli et al.
The high rate of protein synthesis in beta-cells renders them susceptible to endoplasmic reticulum (ER) stress, a condition that can be aggravated by additional imbalances in ER homeostasis and could potentially contribute to the pathogenes...
George V Z Dedoussis,Andriana C Kaliora,Demosthenes B Panagiotakos
George V Z Dedoussis
Diabetes mellitus is widely recognized as one of the leading causes of death and disability. While insulin insensitivity is an early phenomenon partly related to obesity, pancreatic beta-cell function declines gradually over time even befor...
Harold W de Valk,Eduard A van der Graaf
Harold W de Valk
Cystic fibrosis (CF), a dysfunction of the exocrine glands, is one of the most frequently diagnosed genetic diseases. It is characterized by chronic pulmonary disease and pancreatic deficiency. Cystic fibrosis-related diabetes (CFRD) is a c...