SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset [0.03%]
SLC30A8（ZnT8）多态性与1型糖尿病的年轻发病年龄相关
Henning Gohlke,Uta Ferrari,Kerstin Koczwara et al.
Henning Gohlke et al.
It was recently shown that the major allele of the SLC30A8 (zinc transporter 8, ZnT8) single nucleotide polymorphism (SNP) rs13266634 was associated with type 2 diabetes and with reduced insulin secretion in non-diabetic relatives. Because ...
The role of skeletal muscle sphingolipids in the development of insulin resistance [0.03%]
骨骼肌鞘脂在胰岛素抵抗发展中的作用
Marek Straczkowski,Irina Kowalska
Marek Straczkowski
Insulin resistance is an important risk factor for type 2 diabetes, obesity, cardiovascular disease, polycystic ovary syndrome and other diseases. The most important stage in the development of insulin resistance is impairment of insulin-st...
Frantisek Saudek,Carl-Henrik Brogren,Srirang Manohar
Frantisek Saudek
Diabetes is a disorder characterized by beta-cell loss or exhaustion and insulin deficiency. At present, knowledge is lacking on the underlying causes and for the therapeutic recovery of the beta-cell mass. A better understanding of diabete...
The incidence of microalbuminuria and its associated risk factors in type 2 diabetic patients in isfahan, iran [0.03%]
伊朗伊斯法罕2型糖尿病患者微量白蛋白尿患病率及其危险因素调查
Massoud Amini,Hassan Safaei,Ashraf Aminorroaya
Massoud Amini
Aim: The study was carried out to determine the five-year incidence of microalbuminuria and to assess its associated risk factors for type 2 diabetic patients in Isfahan, Iran. ...
First-degree relatives of patients with type 2 diabetes mellitus and risk of non-alcoholic Fatty liver disease [0.03%]
2型糖尿病患者的一级亲属与非酒精性脂肪肝病发病风险的相关性研究
Atoosa Adibi,Mohsen Janghorbani,Sanaz Shayganfar et al.
Atoosa Adibi et al.
Aims: The aim of this study was to determine whether first-degree relatives (FDR) of patients with type 2 diabetes mellitus (T2DM) are at higher risk of non-alcoholic fatty liver disease (NAFLD) than healthy controls. ...
Evaluation of Apolipoprotein M Serum Concentration as a Biomarker of HNF-1alpha MODY [0.03%]
评估载脂蛋白M血清浓度作为HNF-1α糖尿病的生物标志物价值
Jan Skupien,Grzegorz Kepka,Sylwia Gorczynska-Kosiorz et al.
Jan Skupien et al.
Apolipoprotein M (apoM) is a 26-kDa protein expressed mainly in the liver and kidneys. It is present predominantly in high-density lipoproteins (HDL). ApoM expression is influenced by the hepatocyte nuclear factor-1alpha (HNF-1alpha), which...
Effectiveness of an intensive nutritional intervention in patients with type 2 diabetes mellitus: results from a pilot study [0.03%]
一项针对2型糖尿病患者密集营养干预有效性的试点研究结果
Mary Yannakoulia,Kalliopi-Anna Poulia,Eleni Mylona et al.
Mary Yannakoulia et al.
The aim of this pilot study was to compare the effects of an intensive nutritional intervention with usual care conditions on dropout rate, body weight, lifestyle changes and glycemic control in patients with type 2 diabetes mellitus (T2DM)...
Hideaki Kaneto,Takeshi Miyatsuka,Dan Kawamori et al.
Hideaki Kaneto et al.
It is well known that pancreatic and duodenal homeobox factor-1 (PDX-1) plays a pleiotropic role in the pancreas. In the developing pancreas, PDX-1 is involved in both pancreas formation and beta-cell differentiation. In mature beta-cells, ...
TNFalpha in the pathogenesis of diabetes-induced embryopathies: functions and targets [0.03%]
肿瘤坏死因子α在糖尿病致胚胎病发病机制中的作用和靶点
Arkady Torchinsky,Vladimir Toder
Arkady Torchinsky
Hyperglycemia-induced increase in the production of reactive oxygen species (ROS) is proposed to be an initial step in the pathogenesis of diabetes-induced spontaneous abortions and structural inborn anomalies. However, the subsequent steps...
Bromocriptine-induced hyperglycemia in nonobese diabetic mice: kinetics and mechanisms of action [0.03%]
溴隐亭致非肥胖糖尿病小鼠高血糖的动态变化及作用机制
Sylvie Durant,Josiane Coulaud,Francoise Homo-Delarche
Sylvie Durant
The effects of bromocriptine (10 mg/kg), known to inhibit prolactin secretion and lower autoimmune processes, were studied on glucose homeostasis in non-fasted non-obese diabetic mice, a spontaneous model of type 1 diabetes. Hyperglycemia w...