Factors Associated with the Prevalence of Diabetes Mellitus Among Elderly Men and Women Living in Mediterranean Islands: The MEDIS Study [0.03%]
地中海岛屿老年人糖尿病患病率的危险因素：MEDIS研究
Stefanos Tyrovolas,Akis Zeimbekis,Vassiliki Bountziouka et al.
Stefanos Tyrovolas et al.
Background: The aim of the present work was to evaluate the relationships between socio-demographic, clinical, lifestyle and psychological characteristics and the presence of diabetes mellitus, among elderly individuals w...
GAD65-Specific Cytotoxic T Lymphocytes Mediate Beta-Cell Death and Loss of Function [0.03%]
GAD65特异的细胞毒性T淋巴细胞介导β细胞凋亡及功能丧失
Sarah Rasche,Rhea Y Busick,Anthony Quinn
Sarah Rasche
Autoimmunity to islet cell antigens like glutamic acid decarboxylase 65kD (GAD65) is associated with the destruction of insulin-producing beta-cells and progression to type 1 diabetes (T1D) in NOD mice and humans. T cell responses to GAD65 ...
Anders A F Sima,Weixian Zhang,Christian W Kreipke et al.
Anders A F Sima et al.
Encephalopathy is an increasingly recognized complication of type 1 diabetes. The underlying mechanisms are not well understood, although insulin deficiency has been implicated. The spontaneously diabetic BB/Wor-rat develops neuro-behaviora...
Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations [0.03%]
作为抗糖尿病药物新靶点的单磷酸腺苷激活的蛋白激酶(AMPK):代谢、药理及化学因素综述
Arie Gruzman,Gali Babai,Shlomo Sasson
Arie Gruzman
In view of the epidemic nature of type 2 diabetes and the substantial rate of failure of current oral antidiabetic drugs the quest for new therapeutics is intensive. The adenosine monophosphate-activated protein kinase (AMPK) is an importan...
The Individualized Target HbA1c: A New Method for Improving Macrovascular Risk and Glycemia Without Hypoglycemia and Weight Gain [0.03%]
个体化血糖控制目标：不用怕低血糖和体重增加的新方法
Roy Eldor,Itamar Raz
Roy Eldor
Both the DCCT and UKPDS trials demonstrated that improved glycemic control reduces microvascular complications. Inconclusive evidence, however, has remained on the question of the effect of glycemic control on macrovascular disease (with sp...
Effects of Cardiorespiratory Fitness on Serum Ferritin Concentration and Incidence of Type 2 Diabetes: Evidence from the Aerobics Center Longitudinal Study (ACLS) [0.03%]
有氧运动对血清铁蛋白浓度和2型糖尿病发病率的影响：来自有氧运动纵向研究（ACLS）的证据
Tuan D Le,Sejong Bae,Chiehwen Ed Hsu et al.
Tuan D Le et al.
Background: Cardiorespiratory fitness (CRF) and physical activity (PA) are inversely related to the occurrence of type 2 diabetes (T2D). Both play an important role in reducing serum ferritin (SF) concentration. Increased...
Dose- and Glucose-Dependent Effects of Amino Acids on Insulin Secretion from Isolated Mouse Islets and Clonal INS-1E Beta-Cells [0.03%]
剂量和葡萄糖依赖性氨基酸对小鼠分离胰岛和INS-1E克隆细胞的分泌的影响
Zhenping Liu,Per B Jeppesen,Søren Gregersen et al.
Zhenping Liu et al.
Background: The influence of glucose and fatty acids on beta-cell function is well established whereas little is known about the role of amino acids (AAs). ...
Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene [0.03%]
1型糖尿病中的蛋白质翻译后修饰——PCMT1基因及其所编码修复酶异天冬酰胺甲基转移酶(PIMT)的遗传学研究
Ana M Wägner,Paul Cloos,Regine Bergholdt et al.
Ana M Wägner et al.
Background: Posttranslational protein modifications have been implicated in the development of autoimmunity. Protein L-isoaspartate (D-aspartate) O-methyltransferase (PIMT) repairs modified proteins and is encoded by PCMT...
Combined determination of glucose and fructosamine in vitreous humor as a post-mortem tool to identify antemortem hyperglycemia [0.03%]
玻璃体糖化血红蛋白和葡萄糖联合检测作为法医判定生前高血糖的方法
Guillermo Vivero,Guillermo Vivero-Salmerón,Maria D Pérez Cárceles et al.
Guillermo Vivero et al.
In clinical practice, serum glucose levels are used to diagnose diabetes mellitus. In post-mortem diagnosis, however, biochemical markers in vitreous humor are more useful because of the difficulty involved in interpreting blood glucose lev...
Chee Gee Liew,Peter W Andrews
Chee Gee Liew
Transplantation of pancreatic islets offers a direct treatment for type 1 diabetes and in some cases, insulin-dependent type 2 diabetes. However, its widespread use is hampered by a shortage of donor organs. Many extant studies have focused...