Mitochondrial DNA variants in the pathogenesis of type 2 diabetes - relevance of asian population studies [0.03%]
线粒体DNA变异与2型糖尿病发病机制的相关性-亚洲人群研究的意义
Pei-Wen Wang,Tsu-Kung Lin,Shao-Wen Weng et al.
Pei-Wen Wang et al.
Mitochondrial dysfunction involves defective insulin secretion by pancreatic beta-cells, and insulin resistance in insulin-sensitive tissues such as muscle and adipose tissue. Mitochondria are recognized as the most important cellular sourc...
Natalia Vallianou,Angelos Evangelopoulos,Pavlos Koutalas
Natalia Vallianou
Diabetic neuropathy presents a major public health problem. It is defined by the symptoms and signs of peripheral nerve dysfunction in diabetic patients, in whom other causes of neuropathy have been excluded. Pathogenetic mechanisms that ha...
Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-Peptide [0.03%]
1型糖尿病脑病的序贯异常及C-肽的影响
Anders A F Sima,Weixian Zhang,Otto Muzik et al.
Anders A F Sima et al.
Diabetic encephalopathy is a recently recognized complication in type 1 diabetes. In this review, we summarize a series of experimental results obtained longitudinally in the spontaneously type 1 diabetic BB/Wor-rat, and bringing out the be...
Lina Nordquist,John Wahren
Lina Nordquist
Proinsulin C-peptide has been found to exert beneficial effects in many tissues affected by diabetic microvascular complications, including the kidneys. Glomerular hyperfiltration and microalbuminuria are early markers of diabetic nephropat...
Hideki Kamiya,Weixian Zhang,Anders A F Sima
Hideki Kamiya
Diabetic polyneuropathy (DPN) is a common complication in diabetes. At present, there is no adequate treatment, and DPN is often debilitating for patients. It is a heterogeneous disorder and differs in type 1 and type 2 diabetes. An importa...
C-Peptide in the vessel wall [0.03%]
血管壁中的C-肽
Daniel Walcher,Nikolaus Marx
Daniel Walcher
Patients with insulin resistance and early type 2 diabetes exhibit an increased sensitivity to develop a diffuse and extensive pattern of arteriosclerosis leading to a remarkable increase in vascular complications, including myocardial infa...
Jaime Haidet,Vincenza Cifarelli,Massimo Trucco et al.
Jaime Haidet et al.
C-peptide, historically considered a biologically inactive peptide, has been shown to exert insulin-independent biological effects on a number of cells proving itself as a bioactive peptide with anti-inflammatory properties. Type 1 diabetic...
Molecular effects of C-Peptide in microvascular blood flow regulation [0.03%]
C-肽在微血管血流量调节中的分子作用机制研究
Thomas Forst,Thomas Hach,Thomas Kunt et al.
Thomas Forst et al.
C-Peptide is produced in beta-cells in the pancreas, and secreted into the blood stream in equimolar amounts with insulin. For a long time, C-peptide was considered as an important component in the biosynthesis of insulin, but otherwise bel...
A Molecular Level Understanding of Zinc Activation of C-peptide and its Effects on Cellular Communication in the Bloodstream [0.03%]
锌激活C肽及其对血液中细胞通讯的影响的分子机理研究
Wathsala Medawala,Patrick McCahill,Adam Giebink et al.
Wathsala Medawala et al.
Inspired by previous reports, our group has recently demonstrated that C-peptide exerts beneficial effects upon interactions with red blood cells (RBCs). These effects can be measured in RBCs obtained from animal models of both type 1 diabe...