The humanized NOD/SCID mouse as a preclinical model to study the fate of encapsulated human islets [0.03%]
人源化NOD/SCID小鼠作为研究封装人胰岛命运的临床前模型
Vijayaganapathy Vaithilingam,Jose Oberholzer,Gilles J Guillemin et al.
Vijayaganapathy Vaithilingam et al.
Despite encouraging results in animal models, the transplantation of microencapsulated islets into humans has not yet reached the therapeutic level. Recent clinical trials using microencapsulated human islets in barium alginate showed the p...
Dendritic cell-targeted pancreatic beta-cell antigen leads to conversion of self-reactive CD4(+) T cells into regulatory T cells and promotes immunotolerance in NOD mice [0.03%]
树突细胞靶向的胰腺β细胞抗原可将自身反应性CD4+T细胞转化为调节性T细胞并促进NOD小鼠免疫耐受
Cathleen Petzold,Julia Riewaldt,Tina Koenig et al.
Cathleen Petzold et al.
Studies employing T cell receptor transgenic T cells have convincingly shown that selective delivery of non-self model antigens to DEC-205(+) dendritic cells (DCs) in the steady-state can induce Foxp3-expressing CD4(+)CD25(+) regulatory T (...
Glucose homeostasis in pre-diabetic NOD and lymphocyte-deficient NOD/SCID mice during gestation [0.03%]
非肥胖糖尿病小鼠及淋巴细胞缺乏的非肥胖糖尿病/严重联合免疫缺陷小鼠在妊娠期间糖稳态的改变
Josiane Coulaud,Sylvie Durant,Francoise Homo-Delarche
Josiane Coulaud
Background: Unlike other strains, spontaneously type 1 non-obese diabetic (NOD) experience transient hyperinsulinemia after weaning. The same applies for NOD/SCID mice, which lack functional lymphocytes, and unlike NOD mi...
The role of diet and lifestyle in primary, secondary, and tertiary diabetes prevention: a review of meta-analyses [0.03%]
饮食和生活方式在糖尿病一级、二级和三级预防中的作用：系统性回顾及meta分析评估
Theodora Psaltopoulou,Ioannis Ilias,Maria Alevizaki
Theodora Psaltopoulou
Prevention of diabetes is crucial to lowering disease incidence, and thus minimizing the individual, familial, and public health burden. The purpose of this review is to gather current information from meta-analyses on dietary and lifestyle...
Dario Pitocco,Francesco Zaccardi,Enrico Di Stasio et al.
Dario Pitocco et al.
In the recent decades, oxidative stress has become focus of interest in most biomedical disciplines and many types of clinical research. Increasing evidence from research on several diseases show that oxidative stress is associated with the...
Functional alterations of proinflammatory monocytes by T regulatory cells: implications for the prevention and reversal of type 1 diabetes [0.03%]
调节性T细胞对促炎单核细胞的功能调控作用：对I型糖尿病的预防和逆转的意义
Charles Sia,Arno Hänninen
Charles Sia
The onset and development of type 1 diabetes (T1D) occurs in genetically predisposed individuals, and is attributed to autoimmune destruction of pancreatic beta-cells involving a multitude of immune mechanisms. Defects in immune regulation ...
Imaging Pancreatic Beta-Cells: Update from the 4th Workshop of the National Institutes of Health, Washington DC, April 2009 [0.03%]
胰腺β细胞影像学：2009年美国国立卫生研究院会议更新要点(华盛顿，2009年4月)
Frederic Ris,Lindsey Crowe,Thierry Berney
Frederic Ris
There is a crucial need for developing clinically useful approaches to measure pancreatic islet mass and function. Islets represent a small percentage of the tissue located in the abdominal cavity. They remain difficult to study in vivo by ...
Physical activity and reported barriers to activity among type 2 diabetic patients in the United arab emirates [0.03%]
阿联酋2型糖尿病患者的体力活动及其影响因素
Juma Al-Kaabi,Fatma Al-Maskari,Hussein Saadi et al.
Juma Al-Kaabi et al.
Objectives: This study was designed to assess the physical activity practice among type 2 diabetic patients in the United Arab Emirates (UAE). Methods: ...
Mesenchymal stem cells derived from bone marrow of diabetic patients portrait unique markers influenced by the diabetic microenvironment [0.03%]
糖尿病患者骨髓来源的间充质干细胞表达独特的由糖尿病微环境影响而来的标志物
Smruti M Phadnis,Surendra M Ghaskadbi,Anandwardhan A Hardikar et al.
Smruti M Phadnis et al.
Cellular microenvironment is known to play a critical role in the maintenance of human bone marrow-derived mesenchymal stem cells (BM-MSCs). It was uncertain whether BM-MSCs obtained from a 'diabetic milieu' (dBM-MSCs) offer the same regene...
Preclinical and Clinical Data on Extraglycemic Effects of GLP-1 Receptor Agonists [0.03%]
GLP-1受体激动剂的体内外分泌效应的实验和临床数据
Baptist Gallwitz
Baptist Gallwitz
The diverse actions of the incretin hormone glucagon-like peptide (GLP)-1 include insulinotropic, beta-cell preservative, cardioprotective and vasodilatory effects. This spectrum makes GLP-1 an appealing therapeutic option for patients with...