A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients [0.03%]
俄罗斯患者中包含rs752854、rs10010131和rs734312少数allele的WFS1基因型对2型糖尿病具有保护作用
Dimitry A Chistiakov,Dmitry S Khodyrev,Svetlana A Smetanina et al.
Dimitry A Chistiakov et al.
Background: Rare variants of the WFS1 gene encoding wolframin cause Wolfram syndrome, a monogenic disease associated with diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. In contrast, common variants of...
Increased levels of total P-Cresylsulphate and indoxyl sulphate are associated with coronary artery disease in patients with diabetic nephropathy [0.03%]
糖尿病肾病患者总P-对氯苯硫铵和吲哚硫酸水平升高与冠状动脉疾病有关
Cheng-An Chiu,Li-Fen Lu,Teng-Hung Yu et al.
Cheng-An Chiu et al.
Background: Indoxyl sulphate (IS) and p-cresylsulphate (PCS) are uremic toxins with similar protein-binding, dialytic clearance, and proinflammatory features. Few studies have evaluated the possible associations between t...
Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation [0.03%]
锌及锌转运蛋白在胰岛中的调节以及锌在胰岛移植中的潜在作用
Mariea D Bosco,Daisy M Mohanasundaram,Chris J Drogemuller et al.
Mariea D Bosco et al.
The critical trace element zinc is essential for normal insulin production, and plays a central role in cellular protection against apoptosis and oxidative stress. The regulation of zinc within the pancreas and β-cells is controlled by the...
Shankaracharya,Devang Odedra,Subir Samanta et al.
Shankaracharya et al.
The development of an effective diabetes diagnosis system by taking advantage of computational intelligence is regarded as a primary goal nowadays. Many approaches based on artificial network and machine learning algorithms have been develo...
Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index [0.03%]
脂联素基因多态性与体重指数的关联的性别差异分析
Ozra Tabatabaei-Malazy,Shirin Hasani-Ranjbar,Mahsa M Amoli et al.
Ozra Tabatabaei-Malazy et al.
Objective: Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D). The study evaluated possible associations of +45T/G and -11391G/A adiponectin gene polymorphisms with bo...
Effects of different protein sources on plasminogen inhibitor-1 and factor VII coagulant activity added to a fat-rich meal in type 2 diabetes [0.03%]
不同蛋白质来源对2型糖尿病患者进餐后血浆胰蛋白酶抑制物-1和凝血因子VII活性的影响
Lene S Mortensen,Claus Thomsen,Kjeld Hermansen
Lene S Mortensen
Background: Exaggerated postprandial triglyceride concentration is believed to be atherogenic, and to influence the risk of thrombosis. Both elevated plasminogen inhibitor 1 (PAI-1) and increased factor VII coagulant acti...
Randomized Controlled Trial
The review of diabetic studies : RDS. 2010 Fall;7(3):233-40. DOI:10.1900/RDS.2010.7.233 2010
Effects of insulin versus sulphonylurea on beta-cell secretion in recently diagnosed type 2 diabetes patients: a 6-year follow-up study [0.03%]
新诊断的2型糖尿病患者胰岛素与磺脲类药物对β细胞分泌的影响：一项6年随访研究
Michael Alvarsson,Kerstin Berntorp,Eva Fernqvist-Forbes et al.
Michael Alvarsson et al.
Background: Early insulin treatment is considered more beneficial than anti-diabetic medication with sulphonylureas, because the latter may exert negative effects on beta-cell function, while the former may help preserve ...
Randomized Controlled Trial
The review of diabetic studies : RDS. 2010 Fall;7(3):225-32. DOI:10.1900/RDS.2010.7.225 2010
CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice [0.03%]
CXC基序趋化因子配体10的DNA疫苗联合完成弗氏佐剂逆转非肥胖型糖尿病小鼠高血糖状态
Yoichi Oikawa,Akira Shimada,Yoshifumi Yamada et al.
Yoichi Oikawa et al.
Objective: Complete Freund's Adjuvant (CFA) is known to arrest autoimmune diabetes development in non-obese diabetic (NOD) mice. However, CFA alone cannot induce effective remission in diabetic NOD mice. Previously, we re...
German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results [0.03%]
德国新发青年糖尿病队列研究：DiMelli 研究设计与第一年成果
Leonore Thümer,Kerstin Adler,Ezio Bonifacio et al.
Leonore Thümer et al.
Background: Diabetes incidence in childhood and youth is increasing worldwide, including autoimmune and non-autoimmune cases. Recent findings suggest that there is a larger than expected proportion of type 2 diabetes in y...
Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications [0.03%]
糖尿病心脏病研究（DHS）系列研究述评——用于2型糖尿病及其并发症遗传和流行病学研究的全面分析样本
Donald W Bowden,Amanda J Cox,Barry I Freedman et al.
Donald W Bowden et al.
The Diabetes Heart Study (DHS) is a genetic and epidemiological study of 1,443 European American and African American participants from 564 families with multiple cases of type 2 diabetes. Initially, participants were comprehensively examin...