Peptides and their potential role in the treatment of diabetes and obesity [0.03%]
肽及其在糖尿病和肥胖症治疗中的潜在作用
Hannah C Greenwood,Stephen R Bloom,Kevin G Murphy
Hannah C Greenwood
It is estimated that 347 million people worldwide have diabetes and that over 1.5 billion adults worldwide are overweight. Predictions suggest these rates are increasing. Diabetes is a common complication in overweight and obese subjects, a...
SGLT-2 inhibitors in development for type 2 diabetes treatment [0.03%]
处于研发阶段的钠-葡萄糖协同转运蛋白2抑制剂用于治疗2型糖尿病
Mithun Bhartia,Abd A Tahrani,Anthony H Barnett
Mithun Bhartia
The prevalence of type 2 diabetes is increasing worldwide. The majority of currently available glucose-lowering agents work via insulin-dependent mechanisms and have significant limitations. Hence, there is a need for newer treatments utili...
Jonatan I Bagger,Mikkel Christensen,Filip K Knop et al.
Jonatan I Bagger et al.
It has long been known that peptide hormones from the gastrointestinal tract have significant impact on the regulation of nutrient metabolism. Among these hormones, incretins have been found to increase insulin secretion, and thus incretin-...
Simona Cernea
Simona Cernea
The pathogenetic mechanisms causing type 2 diabetes are complex, and include a significant reduction of the incretin effect. In patients with type 2 diabetes, GLP-1 secretion may be impaired, while GIP secretion seems unaffected. In contras...
Alan J Garber
Alan J Garber
Although newer treatments for type 2 diabetes (T2D) patients have produced continual improvements in outcome, a large and growing population with prediabetes remains under-treated. In the last few years, incretin-based therapies have become...
Carolyn F Deacon,Bo Ahrén
Carolyn F Deacon
The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are gut peptides which are secreted by endocrine cells in the intestinal mucosa. Their plasma concentrations increase quickly fol...
The continuing need for drug development and clinical trials in type 2 diabetes and its complications: introduction to the RDS special issue [0.03%]
2型糖尿病及其并发症的药物研发和临床试验的持续需求：RDS专题介绍
Itamar Raz,Baptist Gallwitz
Itamar Raz
The increased burden of type 2 diabetes (T2D) necessitates the need for effective and safe novel drugs to treat this epidemic disease and its complications. By compiling this RDS Special Issue, our aim was to provide a comprehensive and cri...
The frequency of prediabetes and contributing factors in patients with chronic kidney disease [0.03%]
慢性肾脏病患者前期糖尿病患病率及其影响因素分析
Effat Razeghi,Peimaneh Heydarian,Mahshid Heydari
Effat Razeghi
Aims: Uremia is a prediabetic state, but abnormal glucose metabolism and relative risk factors in non-diabetic chronic kidney disease (CKD) patients are not studied extensively. This study aimed to evaluate prediabetes an...
Esophageal dysmotility is more common than gastroparesis in diabetes mellitus and is associated with retinopathy [0.03%]
糖尿病患者的食管运动功能障碍比胃轻瘫更常见，并且与视网膜病变相关
Rita J Gustafsson,Bengt Littorin,Kerstin Berntorp et al.
Rita J Gustafsson et al.
Objectives: Gastroparesis is a well-known complication of diabetes mellitus, both in symptomatic and asymptomatic patients. Esophageal dysmotility has also been described, but is not as well-characterized. The etiology an...
Multicenter Study
The review of diabetic studies : RDS. 2011 Summer;8(2):268-75. DOI:10.1900/RDS.2011.8.268 2011
Results of pancreas transplantation alone with special attention to native kidney function and proteinuria in type 1 diabetes patients [0.03%]
胰腺移植对1型糖尿病患者原肾功能和蛋白尿的影响及胰腺移植的疗效分析
Ugo Boggi,Fabio Vistoli,Gabriella Amorese et al.
Ugo Boggi et al.
We report on our single-center experience with pancreas transplantation alone (PTA) in 71 patients with type 1 diabetes, and a 4-year follow-up. Portal insulin delivery was used in 73.2% of cases and enteric drainage of exocrine secretion i...