Virus infections as potential targets of preventive treatments for type 1 diabetes [0.03%]
病毒感染可能是1型糖尿病预防治疗的目标
Noora Nurminen,Sami Oikarinen,Heikki Hyöty
Noora Nurminen
Environmental factors play an important role in the pathogenesis of type 1 diabetes, and are attractive targets for preventive interventions. Several studies have shown that viruses can cause diabetes in animals, indicating their potential ...
Outi Vaarala
Outi Vaarala
The gut immune system has a key role in the development of autoimmune diabetes, and factors that control the gut immune system are also regulators of beta-cell autoimmunity. Gut microbiota modulate the function of the gut immune system by t...
Metabolomics in the studies of islet autoimmunity and type 1 diabetes [0.03%]
代谢组学在胰岛自身免疫和1型糖尿病研究中的作用
Matej Oresic
Matej Oresic
The metabolome is sensitive to genetic and environmental factors contributing to complex diseases such as type 1 diabetes (T1D). Metabolomics is the study of biochemical and physiological processes involving metabolites. It is therefore one...
Yulan Jin,Jin-Xiong She
Yulan Jin
Biomarkers are useful tools for research into type 1 diabetes (T1D) for a number of purposes, including elucidation of disease pathogenesis, risk prediction, and therapeutic monitoring. Susceptibility genes and islet autoantibodies are curr...
From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era [0.03%]
从标记到分子机制：GWAS后天1型糖尿病研究时代的发展趋势
Alan G Baxter,Margaret A Jordan
Alan G Baxter
By the year 2000, a draft of the human genome sequence was completed. Millions of single-nucleotide polymorphisms (SNPs) had been deposited into public databases, and high throughput technologies were under development for SNP genotyping. A...
Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22 [0.03%]
蛋白酪氨酸磷酸酶与1型糖尿病：PTPN2和PTPN22的遗传学及功能研究意义
Karen Cerosaletti,Jane H Buckner
Karen Cerosaletti
Protein tyrosine phosphatases (PTPs) play a central role in modulating the transduction of cellular signals, including the cells of the immune system. Several PTPs, PTPN22, PTPN2, and UBASH3A, have been associated with risk of type 1 diabet...
Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes [0.03%]
比较基因组学：通过人类和NOD小鼠研究的协同作用来鉴定一型糖尿病的遗传病因
John P Driver,Yi-Guang Chen,Clayton E Mathews
John P Driver
Although once widely anticipated to unlock how human type 1 diabetes (T1D) develops, extensive study of the nonobese diabetic (NOD) mouse has failed to yield effective treatments for patients with the disease. This has led many to question ...
Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease [0.03%]
1型糖尿病的致病机制：胰岛既是靶点也是疾病驱动力
Kate L Graham,Robyn M Sutherland,Stuart I Mannering et al.
Kate L Graham et al.
Recent advances in our understanding of the pathogenesis of type 1 diabetes have occurred in all steps of the disease. This review outlines the pathogenic mechanisms utilized by the immune system to mediate destruction of the pancreatic bet...
Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes [0.03%]
遗传分析与一型糖尿病：胚胎干细胞作为新工具解锁一型糖尿病的生物机制
Nick Holmes,Anne Cooke
Nick Holmes
The nonobese diabetic (NOD) mouse has provided an important animal model for studying the mechanism and genetics of type 1 diabetes over the past 30 years. Arguably, the bio-breeding (BB) rat model may be an even closer phenotypic mimic of ...
The rs11705701 G>A polymorphism of IGF2BP2 is associated with IGF2BP2 mRNA and protein levels in the visceral adipose tissue - a link to type 2 diabetes susceptibility [0.03%]
IGF2BP2基因rs11705701G>A多态性与肠体脂肪组织中IGF2BP2的mRNA和蛋白质水平相关-与2型糖尿病易感性的关联
Dimitry A Chistiakov,Alexey G Nikitin,Svetlana A Smetanina et al.
Dimitry A Chistiakov et al.
Background: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) regulates translation of IGF2, a growth factor that plays a key role in controlling fetal growth and organogenesis including adipogenesis and pancr...