Islet transplantation in type 1 diabetes: ongoing challenges, refined procedures, and long-term outcome [0.03%]
1型糖尿病的胰岛移植：面临的挑战、改进的方法及长期预后
A M James Shapiro
A M James Shapiro
Remarkable progress has been made in islet transplantation over a span of 40 years. Once just an experimental curiosity in mice, this therapy has moved forward, and can now provide robust therapy for highly selected patients with type 1 dia...
CD3 monoclonal antibodies: a first step towards operational immune tolerance in the clinic [0.03%]
临床实现操作免疫耐受性的第一步：CD3单克隆抗体
Lucienne Chatenoud,Herman Waldmann
Lucienne Chatenoud
Type 1 diabetes (T1D) is a prototypic organ-specific autoimmune disease resulting from the selective destruction of insulin-secreting β-cells within the pancreatic islets of Langerhans. It is caused by an immune-mediated inflammation, invo...
Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience [0.03%]
临床免疫耐受网络（ITN）在1型糖尿病的免疫治疗方面的经验
Mario R Ehlers,Gerald T Nepom
Mario R Ehlers
Reestablishing immune tolerance in type 1 diabetes (T1D), a chronic autoimmune disease, is a major goal. The Immune Tolerance Network (ITN) has initiated eight clinical trials of immunomodulatory therapies in recent-onset T1D over the past ...
In vivo delivery of nucleic acid-formulated microparticles as a potential tolerogenic vaccine for type 1 diabetes [0.03%]
以微粒递送核酸为方式的耐受性疫苗在体内的传输潜在地可以治疗一型糖尿病
Valentina Di Caro,Nick Giannoukakis,Massimo Trucco
Valentina Di Caro
Originally conceived as a method to silence transcription/translation of nascent RNA, nucleic acids aimed at downregulating gene expression have been shown to act at multiple levels. Some of the intriguing features of these gene-silencing n...
Interleukin-1 antagonists and other cytokine blockade strategies for type 1 diabetes [0.03%]
白介素-1拮抗剂及其他细胞因子阻断策略在1型糖尿病中的应用
Thomas Mandrup-Poulsen
Thomas Mandrup-Poulsen
Proinflammatory cytokines stimulate adaptive immunity and attenuate T cell regulation and tolerance induction. They also profoundly impair β-cell function, proliferation, and viability, activities of similar importance in the context of ty...
Clinical potential of antigen-specific therapies in type 1 diabetes [0.03%]
自身抗原特异性免疫疗法在1型糖尿病临床应用中的潜力
Ken T Coppieters,Birgit Sehested Hansen,Matthias G von Herrath
Ken T Coppieters
In type 1 diabetes (T1D), pancreatic beta-cells are attacked and destroyed by the immune system, which leads to a loss of endogenous insulin secretion. The desirable outcome of therapeutic intervention in autoimmune diseases is the restorat...
Tolerance strategies employing antigen-coupled apoptotic cells and carboxylated PLG nanoparticles for the treatment of type 1 diabetes [0.03%]
利用抗原耦联凋亡细胞和羧基化PLG纳米粒子的耐受策略治疗1型糖尿病
Suchitra Prasad,Dan Xu,Stephen D Miller
Suchitra Prasad
The development of therapies that specifically target autoreactive immune cells for the prevention and treatment of type 1 diabetes (T1D) without inducing generalized immunosuppression that often compromises the host's ability to clear non-...
Targeted antigen delivery to DEC-205⁺ dendritic cells for tolerogenic vaccination [0.03%]
DEC-205靶向抗原递呈诱导免疫耐受疫苗接种机制研究
Cathleen Petzold,Sonja Schallenberg,Joel N H Stern et al.
Cathleen Petzold et al.
Dendritic cells (DCs) and Foxp3-expressing CD4⁺ regulatory T (Treg) cells play non-redundant roles in the maintenance of peripheral tolerance to self-antigens, thereby preventing fatal autoimmunity. A common hallmark of intra- and extra-th...
Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes [0.03%]
第1型糖尿病治疗靶点不仅限于T细胞：单核细胞、B细胞和固有淋巴细胞
F Susan Wong,Li Wen
F Susan Wong
Recent clinical trials, investigating type 1 diabetes (T1D), have focused mainly on newly diagnosed individuals who have developed diabetes. We need to continue our efforts to understand disease processes and to rationally design interventi...
Paola Zaccone,Samuel W Hall
Paola Zaccone
The increasing incidence of type 1 diabetes (T1D) and autoimmune diseases in industrialized countries cannot be exclusively explained by genetic factors. Human epidemiological studies and animal experimental data provide accumulating eviden...