Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3 [0.03%]
尿黑素3表达指导的干细胞来源β细胞分化的成熟研究
Talitha van der Meulen,Mark O Huising
Talitha van der Meulen
Type 1 diabetes (T1D) is a devastating disease precipitated by an autoimmune response directed at the insulin-producing beta-cells of the pancreas for which no cure exists. Stem cell-derived beta-cells show great promise for a cure as they ...
Nobuaki Shiraki,Soichiro Ogaki,Shoen Kume
Nobuaki Shiraki
Embryonic stem (ES) cells have been shown to recapitulate normal developmental stages. They are therefore a highly useful tool in the study of developmental biology. Profiling of ES cell-derived cells has yielded important information about...
Rahul Krishnan,Michael Alexander,Lourdes Robles et al.
Rahul Krishnan et al.
Over the last decade, improvements in islet isolation techniques have made islet transplantation an option for a certain subset of patients with long-standing diabetes. Although islet transplants have shown improved graft function, adequate...
Philip A Seymour
Philip A Seymour
Over the last decade, it has been discovered that the transcription factor Sox9 plays several critical roles in governing the development of the embryonic pancreas and the homeostasis of the mature organ. While analysis of pancreata from pa...
Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures [0.03%]
小鼠出生后肝脏和胰腺中的集落形成祖细胞在三维培养中分化为形态不同的表达胰岛素的集落
Liang Jin,Tao Feng,Jing Chai et al.
Liang Jin et al.
In our previous studies, colony-forming progenitor cells isolated from murine embryonic stem cell-derived cultures were differentiated into morphologically distinct insulin-expressing colonies. These colonies were small and not light-reflec...
Comparative Study
The review of diabetic studies : RDS. 2014 Spring;11(1):35-50. DOI:10.1900/RDS.2014.11.35 2014
In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors [0.03%]
人多能干细胞衍生的胰腺祖细胞的体外分化和扩增
Jolanta Chmielowiec,Malgorzata Borowiak
Jolanta Chmielowiec
Recent progress in understanding stem cell biology has been remarkable, especially in deciphering signals that support differentiation towards tissue-specific lineages. This achievement positions us firmly at the beginning of an era of pati...
Derivation of insulin-producing beta-cells from human pluripotent stem cells [0.03%]
从人类多能干细胞中分化出胰岛素生成的β细胞
Jacqueline V Schiesser,Suzanne J Micallef,Susan Hawes et al.
Jacqueline V Schiesser et al.
Human embryonic stem cells have been advanced as a source of insulin-producing cells that could potentially replace cadaveric-derived islets in the treatment of type 1 diabetes. To this end, protocols have been developed that promote the fo...
Evaluation of the Finnish Diabetes Risk Score (FINDRISC) as a screening tool for the metabolic syndrome [0.03%]
芬兰糖尿病风险评分(FINDRISC)作为代谢综合征筛查工具的价值评估研究
Mohsen Janghorbani,Hoseinali Adineh,Masoud Amini
Mohsen Janghorbani
Objectives: Traditionally, the Finnish Diabetes Risk Score (FINDRISC) questionnaire is a screening tool to estimate risk of type 2 diabetes. In this study, we evaluated the ability of FINDRISC to predict the development o...
Polyphenol-rich bilberry ameliorates total cholesterol and LDL-cholesterol when implemented in the diet of Zucker diabetic fatty rats [0.03%]
富含酚类的越橘通过改善血脂谱来缓解ZDF大鼠动脉粥样硬化的发展进程
Lea Brader,Ann Overgaard,Lars P Christensen et al.
Lea Brader et al.
Background: Bilberries and blackcurrants are nutrient sources rich in bioactive components, including dietary fibers, polyphenols, and anthocyanins, which possess potent cardiovascular protective properties. Few studies i...
Effects of whey proteins on glucose metabolism in normal Wistar rats and Zucker diabetic fatty (ZDF) rats [0.03%]
乳清蛋白对正常Wistar大鼠和Zucker糖尿病脂肪症(ZDF)系大鼠糖代谢的影响
Søren Gregersen,Sara Bystrup,Ann Overgaard et al.
Søren Gregersen et al.
Background: Beneficial effects of milk protein on glucose metabolism have been reported. Objectives: We hypothesized that dietary suppl...