Analysis of 470,000 exome-sequenced cases and controls fails to identify any genes impacting risk of developing affective disorder [0.03%]
分析47万例外显子组测序的病例和对照，未发现影响情感障碍发病风险的基因
David Curtis
David Curtis
Objective: A previous analysis of 200,000 exome-sequenced UK Biobank participants using weighted burden analysis of rare, damaging variants failed to identify any genes associated with risk of affective disorder requiring...
Anxiety Disorders in the Middle East and North Africa region: A Comprehensive Analysis from 1990 to 2021 [0.03%]
1990至2021年中东和北非地区焦虑症的全面分析
Reza Aletaha,Ali-Asghar Kolahi,Zahra Mousavi et al.
Reza Aletaha et al.
Objective: This study presents the most recent data on the incidence, prevalence, and years lived with disability (YLDs) due to anxiety disorders across the Middle East and North Africa (MENA) region from 1990-2021, analy...
Psychosocial wellbeing of people with dementia: Systematic review and construct analysis [0.03%]
痴呆患者的身心福祉：系统回顾与结构分析
Lena M Hofbauer,Francisca S Rodriguez
Lena M Hofbauer
Objective: Psychosocial wellbeing is increasingly recognised as a key outcome in dementia research and care, reflecting a shift towards person-centred care and patient-reported outcome measures. However, progress is hinde...
Sex Differences in the Network Structures of Depressive Symptom Profiles in Asian Patients with Depressive Disorders: Findings From the REAP-AD3 [0.03%]
亚洲抑郁症患者抑郁症状谱系的网络结构性别差异：REAP-AD3研究结果
Han Seul Kim,Seonjae Lee,Jeongha Lee et al.
Han Seul Kim et al.
Background: Depression is a complex mental health disorder with highly heterogeneous symptoms that vary significantly across individuals, influenced by various factors, including sex and regional contexts. Network analysi...
Immunopsychiatry of late life depression: role of aging-related immune/inflammatory processes in the development and progression of depression [0.03%]
老年抑郁症的免疫精神医学：与年龄相关性免疫/炎症过程在抑郁发生发展中的作用
Antonio L Teixeira,Izabela G Barbosa,Moises E Bauer et al.
Antonio L Teixeira et al.
Background: Late-life depression (LLD) arises from a complex interplay among biological, psychological, and social factors. Biologically, three main hypotheses have been proposed to explain the distinct clinical features ...
Gender-Affirming Hormone Therapy, Quality of Life, and the Role of Oestradiol and Testosterone in Transgender Individuals [0.03%]
性别肯定激素治疗、生活质量以及雌二醇和睾酮在跨性别者中的作用
E E S Petersen,F Kiy,U S Kesmodel et al.
E E S Petersen et al.
Objectives: The present study examines the quality of life (QoL) of transgender and gender-diverse individuals receiving versus not receiving gender-affirming hormone therapy (GAHT) in those assigned male at birth (AMAB) ...
COMPLEMENT SYSTEM DYSFUNCTION IN AUTISM SPECTRUM DISORDER: EVIDENCE FOR ALTERED C1Q AND C3 LEVELS (COMPLEMENT SYSTEM DYSFUNCTION IN ASD) [0.03%]
自闭症谱系障碍中补体系统的功能紊乱：C1q和C3水平改变的证据
Meltem Günaydın,Özlem Doğan,Fatih Günay et al.
Meltem Günaydın et al.
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impairments in social communication, repetitive behaviors, and restricted interests. Emerging evidence suggests that immune sys...
Effectiveness of Acceptance and Commitment Therapy for Suicidality: A Systematic Review and Meta-analysis [0.03%]
接受承诺疗法对自杀倾向有效性的系统评价和meta分析研究
Ju Hyun Tak,Seo-Eun Cho,Seong-Jin Cho et al.
Ju Hyun Tak et al.
Background: Acceptance and commitment therapy (ACT) is recognized as an effective treatment for a variety of mental illnesses. Several meta-analyses have reported the efficacy of ACT in various mental and physical conditi...
Behavioral impairments in a mouse model of Kabuki syndrome associated with dopaminergic and neuroinflammatory modulations [0.03%]
与多巴胺能和神经炎症相关的小鼠戏剧面谱综合征行为障碍模型的行为损害
Thalles F Biondi,Silvia M G Massironi,Eduardo F Bondan et al.
Thalles F Biondi et al.
Objective: Kabuki syndrome is a rare multisystem congenital disorder characterized by specific facial malformations and several other symptoms, including motor impairments, increased susceptibility to infections, immune m...
Escitalopram alters tryptophan metabolism, plasma lipopolysaccharide, and the inferred functional potential of the gut microbiome in deer mice showing compulsive-like rigidity [0.03%]
艾斯西塔洛普拉姆可改变白尾鹿鼠刚性行为小鼠支链氨基酸代谢、血浆脂多糖及肠道微生物组的推断功能潜力
Larissa Karsten,Brian H Harvey,Dan J Stein et al.
Larissa Karsten et al.
Objective: Compulsive-like rigidity may be associated with hyposerotonergia and increased kynurenine (KYN) pathway activity. Conversion of tryptophan (TRP) to kynurenine (KYN), which may contribute to hyposerotonergia, is...