miR-769-5p as a Novel Biomarker and Functional Mediator in Alzheimer's Disease: Targeting CREB5 to Alleviate Oxidative Injury [0.03%]
miR-769-5p作为阿尔茨海默病的新型生物标志物和功能介体：靶向CREB5以缓解氧化损伤
Pengju Ma,Huanxi Cui,Lihong Ren et al.
Pengju Ma et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with mild cognitive impairment (MCI) as its critical prodromal stage. Identifying reliable biomarkers to distinguish AD from MCI is key for early intervention. This study...
In Silico and In Vitro Investigations of Novel Strategies to Combat Drug-Resistant Comamonas aquatica [0.03%]
计算和体外研究对抗药物 resistant comamonas aquatica的新策略
Rupsha Karmakar,Payel Paul,Moumita Malik et al.
Rupsha Karmakar et al.
Comamonas aquatica, an emerging nosocomial pathogen, poses significant clinical challenges through biofilm-mediated antimicrobial resistance. This study investigated the efficacy of cuminaldehyde combined with tetracycline against C. aquati...
Compartment-Specific miRNA Levels in Prostate Cancer: In Situ Profiling of Serum Biomarker Candidates [0.03%]
前列腺癌的室腔特异性血清miRNA水平：体内候选生物标志物分析
Erik Nesje Wiik,Henrik Sahlin Pettersen,Haakon Skogseth et al.
Erik Nesje Wiik et al.
Circulating microRNAs (miRNAs) are promising prostate cancer biomarkers, but their cellular origin and regulatory mechanisms remain unclear. Prostate samples from 70 men (30 prostate cancer, 40 benign) were analyzed by in situ hybridization...
Prognostic Value of microRNA-648 in Osteosarcoma and Its Regulatory Effect on Tumor Progression [0.03%]
microRNA-648在骨肉瘤中的预后价值及其对肿瘤进展的调控作用
Baichun Deng,Pengli Wang,Min Wang et al.
Baichun Deng et al.
The present investigation was designed to assess the prognostic value of microRNA-648 (miR-648) in osteosarcoma (OS) and elucidate its regulatory mechanisms. Quantitative real-time PCR was employed to measure miR-648 expression levels in 80...
Rethinking Bacterial Osteolysis: Translational Evidence From a Porcine Model and Fracture-Related Infections [0.03%]
从猪模型和骨折相关感染中重新思考细菌性骨溶解：转化证据
Anton A N Peterlin,Nicole L Henriksen,Julie M Birch et al.
Anton A N Peterlin et al.
Bone and joint infections (BJIs) are debilitating conditions that reduce quality of life. Key features include interosseous bacteria, biofilm formation, suppurative inflammation, and osteolysis. Traditionally, bacteria-associated osteolysis...
Network Analysis of polA in Acinetobacter baumannii International Clone 2 and Computational Evaluation of Nodulisporone and Nodulisporol as Potential Inhibitors [0.03%]
铜绿假单胞菌国际流行株2型中polA的网络分析及链孢霉菌素和链孢霉索作为潜在抑制剂的计算评估
Dhruva Tirumalasetty,Vamsi Seerla,Akshay Pp et al.
Dhruva Tirumalasetty et al.
Acinetobacter baumannii is a Gram-negative opportunistic pathogen linked to over 400,000 deaths annually, with International Clone 2 (IC2) recognised as a major multidrug-resistant (MDR) lineage. We analysed 668 IC2 genomes from BIGSdb, ass...
Cefepime/Enmetazobactam as a Carbapenem-Sparing Alternative: Activity Against Extended-Spectrum β-Lactamase-Producing Enterobacteria With and Without Carbapenemases in Southern Spain [0.03%]
西司他丁/埃美普酶作为碳青霉烯类药物的替代品：在西班牙南部对产生超广谱β-内酰胺酶和是否同时产生碳青霉烯酶的肠杆菌科细菌的作用
Leticia Castellano-Sánchez,María Aguilera-Franco,Manuel Albendín-Moreno et al.
Leticia Castellano-Sánchez et al.
This study aims to evaluate the activity of Cefepime/enmetazobactam (FEP/META) in a Regional Hospital in southern Spain, against a collection of ESBL-producing Enterobacteriaceae with or without carbapenemases, comparing it with piperacilli...
Hemangioblastoma of the Kidney-A Comprehensive Clinical, Pathological, and Genetic Analysis of Four Cases [0.03%]
肾脏血管母细胞瘤的临床、病理和遗传分析报告四例综合分析
Boglárka Pósfai,Alex Jenei,Gertrúd Forika et al.
Boglárka Pósfai et al.
Hemangioblastoma (HB) is a benign central nervous system (CNS) tumor associated with mutations in the von Hippel-Lindau (VHL) gene. Although rare outside the CNS, the pathological and genetic features remain poorly understood. We analyzed f...
Bedside Post-Mortem Tissue Biopsy: Diagnostic Approach in ICU Patients? [0.03%]
重症监护病房患者的床旁尸体组织活检：诊断方法吗？
Birgitte Grønkær Toft,Lise Mette Rahbek Gjerdrum,Ulf Gøttrup Pedersen et al.
Birgitte Grønkær Toft et al.
YTHDF1 Drives Ferroptosis in Ulcerative Colitis via m6A-ACSL4 Stabilization [0.03%]
YTHDF1通过m6A-ACSL4稳定化驱动溃疡性结肠炎铁死亡
Yanhong Lin,Yanping Zhang,Xiaojun Wang et al.
Yanhong Lin et al.
This study aimed to investigate the role of YTHDF1, a key m6A reader protein, in ulcerative colitis (UC) pathogenesis and its potential involvement in ferroptosis through ACSL4 regulation. Clinical serum and tissue samples from UC patients,...