Hsa_circ_0000140 Mediates the Regulation of Retinal Microvascular Endothelial Function and Inflammation via Sponging miR-485-5p in Diabetic Retinopathy [0.03%]
circRNA hsa_circ_0000140通过海绵作用miR-485-5p介导糖尿病视网膜病变中视网膜微血管内皮功能和炎症的调节
Ting Feng,Ting Yan,Tanwei Wei et al.
Ting Feng et al.
Diabetic retinopathy (DR), an ocular disease resulting from retinal microvascular damage caused by diabetes, has circular RNAs playing a key regulatory role in its progression. We examine the involvement of hsa_circ_0000140 in DR progressio...
Prognostic Value of miR-517c-3p in Lung Cancer and Its Regulatory Effect on Tumor Progression [0.03%]
miR-517c-3p在肺癌中的预后价值及其对肿瘤进展的调控作用
Jia Chen,Qiu Ren,Bowen Sun et al.
Jia Chen et al.
This study investigated the prognostic value and molecular mechanisms of miR-517c-3p in lung cancer. miR-517c-3p in 112 lung cancer tissues was detected using qRT-PCR. Kaplan-Meier survival analysis and Cox regression were used to assess it...
Breaking the Barrier: Cutting-Edge Microbial Strategies Against Candida Biofilm Infections [0.03%]
突破屏障：抗白念珠菌生物被膜感染的微生物前沿策略
Utkalika Mallick,Binaya Krushna Sahu,Sudipta Kumar Patra et al.
Utkalika Mallick et al.
Candida species, particularly Candida albicans and nonalbicans, can form strong biofilms on biotic and abiotic surfaces, leading to chronic and recurring infections. These biofilms are influenced by regulatory circuits, transcription factor...
IHGAMP: Pan-Cancer HRD Prediction From Routine H&E Whole-Slide Images Using Foundation Models [0.03%]
基于基础模型的全癌种HRD状态从常规H&E整张切片图像中预测(IHGAMP)
Sanwal Ahmad Zafar,Liu Chengliang,Areeba Ali Khan et al.
Sanwal Ahmad Zafar et al.
Homologous recombination deficiency (HRD) guides PARP inhibitor and platinum-based therapy selection but relies on costly next-generation sequencing with limited accessibility. Here, we show that IHGAMP, a computational framework using visi...
From 3D Surface Documentation to Visualization in Forensic Practice: A Review of Current Methods and Emerging Technologies [0.03%]
从法医实践中的三维表面记录到可视化：当前方法和新兴技术综述
Haruki Fukuda,Lars Ebert,Florian Kreitmeier et al.
Haruki Fukuda et al.
The accurate documentation of bodies, injuries, death scenes, accidents, and crime scenes is fundamental to forensic investigations. Traditional two-dimensional (2D) photography and written reports have inherent limitations in representing ...
Mapping the Research Landscape and Evolutionary Trends of the Oral Microbiome in Periodontitis [0.03%]
牙周炎口腔微生物组的研究领域和进化趋势的地图制作
Xue Wang,Yihui Ma,Ying Yang et al.
Xue Wang et al.
The conceptual transition from the "Red Complex" paradigm to the "Ecological Plaque Hypothesis" has fundamentally reshaped the understanding of periodontitis, but a quantitative mapping of this intellectual evolution and its emerging resear...
A Survey of the Microbiome, Culturome and ARG Profile of a Cohort of Chronic Diabetic Foot Lesions [0.03%]
慢性糖尿病足溃疡患者微生物组、培养体和ARG特征的调查研究
Karolina I Pyrzanowska,Elspeth N Smith,Chandra Ramalingam et al.
Karolina I Pyrzanowska et al.
This study aimed to analyse the microbiome of chronic infected diabetic foot ulcers (DFUs) using parallel methods: traditional culture (the culturome), 16S rRNA gene sequencing (the microbiome) as well as the Antibiotic Resistance Gene (ARG...
Density-Dependent Modulation of the Oxidative Burst by Neutrophils in Response to Planktonic and Biofilm Growing Pseudomonas aeruginosa: When Less Is More [0.03%]
铜绿假单胞菌浮游菌和生物被膜对密度依赖的中性粒细胞氧化爆发反应：量少则效多
Peter Østrup Jensen,Mads Lichtenberg,Regitze Lund Nielsen et al.
Peter Østrup Jensen et al.
The neutrophilic response to chronic Pseudomonas aeruginosa lung infection is strongly associated with collateral tissue damage impairing lung function in people with cystic fibrosis (pwCF). We recently demonstrated the concurrent presence ...
Immunological Explanations for Autism Initiation From Inflammation and Neurotoxins [0.03%]
从炎症和神经毒素的角度解释自闭症的免疫学原因
Kevin Roe
Kevin Roe
Autism initiation has been associated with genetic vulnerabilities, disruption of gastrointestinal microbes (gut dysbiosis), chemical and neurotoxin damage, maternal infections, allergies or autoimmune diseases. Ingested neurotoxin barriers...
Deep Learning-Based Tumor Cell Classification in Lung Adenocarcinoma With a Case-by-Case Human-in-the-Loop Approach [0.03%]
基于深度学习的肺癌腺癌病例-by-病例的人机交互方式肿瘤细胞分类方法
Martin Stampe,Pia Klausen,Ida Skovgaard Christiansen et al.
Martin Stampe et al.
Deep learning networks trained for classification of single cells in hematoxylin and eosin-stained (H&E) sections are limited in accuracy. We hypothesize the accuracy of a pathologist to be 98%-100%. Digital classification should be on par ...