[Conclusions] [0.03%]
结论
Juan A Pineda
Juan A Pineda
Juan Berenguer Berenguer,Juan González-García
Juan Berenguer Berenguer
Telaprevir is a new direct-acting antiviral drug for the treatment of hepatitis C virus (HCV) infection and is both a substrate and an inhibitor of cytochrome P450 (CYP450) isoenzymes. With the introduction of this new drug, assessment of d...
[Safety and efficacy of telaprevir in patients with HIV and hepatitis C virus coinfection] [0.03%]
泰拉普利韦治疗HIV和丙肝病毒共感染患者的疗效及安全性评估
Juan Macías,Antonio Rivero
Juan Macías
Related to the use of telaprevir in patients with HIV and genotype 1 hepatitis C virus, there is available data from a phase IIb clinical trial in patients not previously treated for HCV, study 110; and preliminary data from a real practice...
[Telaprevir resistance] [0.03%]
特拉匹韦耐药性
Eva Poveda,Federico García
Eva Poveda
Telaprevir is an extremely potent antiviral drug. However, as with other direct-acting antiviral agents against the hepatitis C virus (HCV), this potency can be compromised by the rapid emergence of resistance mutations. This phenomenon is ...
[Clinical use of telaprevir: stopping rules, predicting response, treatment length, and management of adverse effects] [0.03%]
特拉匹韦的临床应用：停药指征、应答预测、疗程以及不良反应管理
Cristina Tural,Ramon Planas
Cristina Tural
Triple combination therapy with pegylated interferon, ribavirin and telaprevir is currently considered the gold standard for the treatment of chronic hepatitis C virus (HCV) infection. The most important features are an increase in rates of...
[Telaprevir in HCV-monoinfected patients with failure to prior treatment] [0.03%]
特拉匹韦治疗既往干扰素治疗失败的丙型肝炎病毒感染患者疗效观察
Ricard Solà,Xavier Forns
Ricard Solà
The introduction of telaprevir in the therapeutic armamentarium for hepatitis C virus infection is a major advance, even in patients unresponsive to prior treatment with interferon and ribavirin. In this group of patients, sustained viral r...
Joaquín Cabezas,Javier Crespo,Josefina Selmo et al.
Joaquín Cabezas et al.
Chronic hepatitis due to the hepatitis C virus (HCV) infection affects nearly 180 million people worldwide. This infection is curable. Until 1 year ago, the only treatment for genotype 1 HCV was the combination of pegylated interferon and r...
Raúl J Andrade,Javier García-Samaniego
Raúl J Andrade
Telaprevir is the first of a new generation of drugs based on blocking the NS3-4A protease of hepatitis C virus (HCV), which is essential for viral reproduction, and is especially active against genotype 1 HCV. However, to be effective, tel...
[Introduction] [0.03%]
简介
Manuel Romero Gómez
Manuel Romero Gómez
Could polymerase chain reaction tests on conjunctival swabs be useful to diagnose herpetic keratitis? [0.03%]
结膜拭子聚合酶链反应检测技术能用于疱疹性角膜炎的诊断吗？
Laura Barrado,M Jesús Suarez,Eugenio Pérez-Blázquez et al.
Laura Barrado et al.
Introduction: Diagnosis of HSV-1 keratitis (HK) is frequently based on clinical findings. Invasive specimens (corneal scrapings, biopsies) are required for microbiological diagnosis. ...