Post-operative hypofractionated stereotactic radiotherapy for brain metastases from lung and breast cancer in patients without prior WBRT: a retrospective dose escalation study [0.03%]
一项回顾性的剂量递增研究：术后分次立体定向放射治疗肺癌和乳腺癌脑转移患者（未接受全脑放疗）
Nicolas Roquet,Arnaud Beddok,Maxime Loo et al.
Nicolas Roquet et al.
This study investigated hypofractionated stereotactic radiotherapy (HSRT) for resected brain metastases and how the dose-fractionation affects local control (LC) and radionecrosis (RN). We retrospectively evaluated patients with brain metas...
Interplay of GPC3, Hsa-miR-135b-3p, and FTLP3 in lung cancer metastasis [0.03%]
GPC3、HSA-MIR-135B-3P和FTLP3在肺癌转移中的互作关系
Lijun Yang,Jiping Li
Lijun Yang
This study investigates crucial genes involved in lung cancer metastasis and their interactions within a Competitive endogenous RNA (ceRNA) regulatory network using comprehensive transcriptomic data from the TCGA and GEO databases. Differen...
A new, immunocompetent brain-metastatic mouse model of HER2-positive breast cancer [0.03%]
一个新的、免疫 competent的脑转移小鼠模型用于HER2阳性乳腺癌的研究
Leran Chen,Angela Chow,Wanchao Ma et al.
Leran Chen et al.
Brain metastasis is a common and devastating complication of cancer that affects over 50% of HER2-positive (HER2+) breast cancer patients. The lack of effective long-term treatment options for brain metastasis significantly increases morbid...
Meiqi Dong,Na Zhang
Meiqi Dong
Tumor metastasis involves the spread of tumor cells from the primary site to distant organs via the lymphatic system, blood vessels, and other pathways. It stands as a major contributor to cancer incidence and mortality. Laminin α5 (LMα5)...
TEAD4 promoted proliferation and metastasis of gallbladder cancer by regulation of TMPRSS4 [0.03%]
TEAD4通过调节TMPRSS4促进胆囊癌的增殖和转移
Conglin Lin,Congren Wang,Mingzhu Li et al.
Conglin Lin et al.
Gallbladder cancer (GBC) is an aggressive malignancy with a poor prognosis, often diagnosed at advanced stages. TEA domain transcription factor 4 (TEAD4) has been implicated in mediating the progression of various cancers, but its function ...
Ras-proximate-1 (RAP1): a prognosis and therapeutic target in the metastatic spread of breast cancer [0.03%]
Ral结合蛋白活化蛋白1(RAP1)：乳腺癌转移的预后和治疗靶点
Hongyi Liang,Guoliang Yin,Dandan Feng et al.
Hongyi Liang et al.
Breast cancer (BC), a highly heterogeneous disease, has demonstrated a gradual increase in both incidence and mortality rates. At present, it has become one of the most common malignant tumors and the main cause of cancer death worldwide. W...
Efficacy and safety of combined anti-vascular and two-staged stereotactic radiosurgery therapy for brain metastases with brainstem compression: a retrospective multicenter study [0.03%]
联合抗血管和分次立体定向放射外科治疗对脑干受压的脑转移瘤的有效性和安全性：一项回顾性多中心研究
Zhu Xiuming,Zhou Jia,Chen Qun et al.
Zhu Xiuming et al.
Stereotactic radiosurgery poses a significant risk when treating brain metastases in close proximity to the brainstem. To address this issue, a novel approach known as "combined anti-vascular therapy" has been devised for these metastases. ...
Multicenter Study
Clinical & experimental metastasis. 2025 Mar 29;42(3):21. DOI:10.1007/s10585-025-10338-1 2025
Brain metastases lung adenocarcinoma patients with BRG1 loss have a grim prognosis, featuring unique morphological and methylation characteristics [0.03%]
BRG1缺失的脑转移肺腺癌患者的预后不良，具有独特的形态和甲基化特征
Junjie Yang,Jing Feng,Zejun Duan et al.
Junjie Yang et al.
BRG1 deficiency in patients with lung adenocarcinoma that has metastasized to the brain, termed BRG1-deficient brain metastasis lung adenocarcinoma, is an uncommon event. Prior to this study, these patients had not undergone extensive molec...
A novel optimized orthotopic mouse model for brain metastasis with sustained cerebral blood circulation and capability of multiple delivery [0.03%]
一种新型优化的正交小鼠脑转移模型，具有持续的脑血循环和多次给药的能力
Zihao Liu,Huisheng Song,Zhenning Wang et al.
Zihao Liu et al.
Brain metastasis is thought to be related to the high mortality and poor prognosis of lung cancer. Despite significant advances in the treatment of primary lung cancer, the unique microenvironment of the brain renders current therapeutic st...
Concomitant medications in patients with metastatic urothelial carcinoma receiving enfortumab vedotin: real-world data from the ARON-2EV study [0.03%]
接受enfortumab vedotin治疗的转移性尿路上皮癌患者的合并用药：来自ARON-2EV研究的真实世界数据
Ondřej Fiala,Sebastiano Buti,Kazutoshi Fujita et al.
Ondřej Fiala et al.
Patients with metastatic urothelial carcinoma (mUC) are typically elderly and often have other comorbidities that require the use of concomitant medications. In our study we evaluated the association of concomitant use of antibiotics (ATBs)...
Multicenter Study
Clinical & experimental metastasis. 2025 Feb 20;42(2):18. DOI:10.1007/s10585-025-10335-4 2025