Targeting metabolic and epigenetic reprogramming in metastatic fumarate hydratase-deficient renal cell carcinoma [0.03%]
靶向代谢和表观遗传重编程以治疗富马酸水合酶缺乏型肾细胞癌转移
Nadja Kührer,Irene Huebner-Resch,Roman Mayr et al.
Nadja Kührer et al.
Fumarate hydratase-deficient renal cell carcinoma (FHdRCC) has been classified under the new category of molecularly defined RCCs according to the WHO classification 2022. Although rare, FHdRCC is an aggressive malignancy with a high metast...
Cold atmospheric plasma-activated liquid inhibits peritoneal metastasis in drug-resistant ovarian cancer by targeting the epithelial-mesenchymal transition [0.03%]
冷等离子活化液通过靶向上皮间质转化抑制耐药性卵巢癌的腹膜转移
Jinren Liu,Xiangni Wang,Yixin Cui et al.
Jinren Liu et al.
Ovarian cancer remains a significant challenge in oncology due to its aggressive nature, late-stage diagnosis, and high rates of chemoresistance, particularly to platinum-based therapies like cisplatin. The epithelial-mesenchymal transition...
A CSF-1R inhibitor both prevents and treats triple-negative breast cancer brain metastases in hematogenous preclinical models [0.03%]
一种CSF-1R抑制剂可预防和治疗血源性三阴乳腺癌脑转移模型中的乳腺癌脑转移病灶
Wei Zhang,Samiur Rahman,Alex M L Wu et al.
Wei Zhang et al.
Brain metastasis is a common and serious complication of metastatic triple-negative breast cancer (TNBC) with few effective treatments. Here, we evaluated the effect of targeting the brain tumor microenvironment via the myeloid colony-stimu...
G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer [0.03%]
G蛋白偶联受体183(GPR183)通过抑制上皮间质转化抑制非小细胞肺癌脏器转移的作用研究
Lei Cheng,Shifang Li,Zhenwen Cui et al.
Lei Cheng et al.
Brain metastasis is a serious complication of non-small cell lung cancer (NSCLC) that contributes to poor survival outcomes despite strides made in systemic treatment regimens. The G protein-coupled receptor GPR183 has been shown to regulat...
Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab [0.03%]
合并使用质子泵抑制剂或心血管药物对接受纳武单抗治疗的转移性肾细胞癌患者的生存结局的影响
Ondřej Fiala,Petr Hošek,Michaela Tkadlecová et al.
Ondřej Fiala et al.
Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to concomitant medicat...
Reconsidering palliative radiotherapy in addition to PD-1 blockade for non-small cell lung cancer: results from the FORCE phase II trial (AIO/YMO-TRK-0415) [0.03%]
从FORCE二期试验(AIO/YMO-TRK-0415)结果重新评估非小细胞肺癌患者在接受PD-1抑制剂治疗的基础上联合姑息性放疗的效果
Farastuk Bozorgmehr,Inn Chung,Jürgen R Fischer et al.
Farastuk Bozorgmehr et al.
Introduction of immune checkpoint inhibitors (ICI) has improved overall survival (OS) for advanced non-small cell lung cancer (NSCLC). However, responses differ greatly amongst patients. Additional radiotherapy (RT) may promote tumor-specif...
Loss of IL13RA2 promotes metastatic tumor growth in triple-negative breast cancer via increased AKT and NF-κB signaling [0.03%]
IL13RA2丢失通过增加AKT和NF-κB信号促进三阴性乳腺癌的转移生长
Wendy E Bindeman,Kevin C Corn,Marjan Rafat et al.
Wendy E Bindeman et al.
Triple-negative breast cancer is associated with poor patient prognosis and high rates of distant metastasis. These patients are at elevated risk of brain metastasis, which remains a major therapeutic challenge. IL13RA2, a high-affinity rec...
The prognostic significance of histopathological growth patterns in liver metastases undergoing surgery: a systematic review and meta-analysis [0.03%]
系统综述和meta分析：手术治疗的肝转移瘤中组织病理学生长模式的预后意义
Xiang-Yu Wang,Bo Zhang,Yin-Chen Gu et al.
Xiang-Yu Wang et al.
Histopathological growth pattern (HGP) is emerging as a promising pathological biomarker in liver metastases, with potential associations to prognosis and response to antiangiogenic therapy. Nonetheless, its prognostic role requires further...
The challenge of disappearing colorectal liver metastasis: balancing considerations between tumor biology and clinical consequence for liver surgery [0.03%]
肝转移瘤消退的挑战：肿瘤生物学和临床结果指导肝脏手术的权衡取舍
Daniel Ansari,Jenny Rystedt,Kjetil Søreide et al.
Daniel Ansari et al.
The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between "resectable" and "unresectable" disease. Also, the use of ...
Renal cell carcinoma with metastasis to the pancreas: a model for oligometastasis, oligoprogression and metastatic organotropism [0.03%]
肾细胞癌胰腺转移：少部位转移、寡进展和转移靶器官倾向性的模型
Kjetil Søreide,Elen Martine Hauge,Maria Nyre Vigmostad
Kjetil Søreide
Metastatic cancer has been considered uniformly fatal in the past with very poor outcomes for most cancer sites. However, novel systemic and targeted therapies have rendered unique responses with longer survival across several cancer types ...