XRN2, governed by RNA-binding protein PTBP3, promotes the invasiveness of esophageal squamous cell carcinoma [0.03%]
受RNA结合蛋白PTBP3调控的XRN2促进食管鳞癌侵袭性进展
Chenglai Dong,Deqi Zhu,Jincao Zhang et al.
Chenglai Dong et al.
Metastasis contributes to treatment failure and poor prognosis of esophageal squamous cell carcinoma (ESCC) patients. The 5'-3' exoribonuclease 2 (XRN2) is related to the pathogenesis and progression of various malignancies through its role...
Safety evaluation of TOPAZ-1 and KEYNOTE-966 regimens in metastatic biliary tract cancer: a systematic review and meta-analysis [0.03%]
TOPAZ-1和KEYNOTE-966方案治疗晚期胆道癌安全性的系统评价和meta分析
Elsa Vitale,Lorenza Maistrello,Francesco Ciccimarra et al.
Elsa Vitale et al.
The addition of immunotherapy to chemotherapy has improved prognosis of metastatic biliary tract cancer (BTC). The present systematic review aimed to assess frequency of treatment-emergent adverse events (TEAEs) among metastatic BTC patient...
NF1 mutation may be associated with lung-tropic metastasis in cutaneous melanoma: a genomic analysis of 520 patients [0.03%]
NF1基因突变可能与皮肤黑色素瘤肺转移相关：520名患者的基因组分析结果
Doğancan Akpalamut
Doğancan Akpalamut
Background: Metastatic organotropism in cutaneous melanoma remains incompletely understood at the genomic level. While prior work has linked BRAF and NRAS mutations to organ-specific metastasis patterns, the role of NF1 h...
Modeling the role of urokinase-type plasminogen activator, uPA, and circulating cancer-associated fibroblasts (cCAFs) in breast cancer cell extravasation [0.03%]
尿激酶型纤溶酶原激活物uPA和循环癌相关成纤维细胞cCAFs在乳腺癌细胞出血管化中的作用机制模拟研究
Angela Spartz,Susan Schmidt,Fazila Mohamed et al.
Angela Spartz et al.
Circulating Cancer-Associated Fibroblasts (cCAFs) have been identified in circulating tumor cell clusters from all stages of disease progression in breast cancer patients. We have shown that CAFs promote lung metastases in the mouse tail ve...
Maria L Price,Jiabao Zhou,Christine L Le Maitre et al.
Maria L Price et al.
Bone metastasis remains a serious threat to breast cancer patients. This condition arises from the outgrowth of previously dormant tumour cells in this site. Dormant tumour cells are almost impossible to detect in human patents, and these c...
Editorial Expression of Concern: Hypermethylation-mediated inactivation of miR-124 predicts poor prognosis and promotes tumor growth at least partially through targeting EZH2/H3K27me3 in ESCC [0.03%]
编辑部关注函：Hypermethylation介导的miR-124失活预测食管鳞癌预后不良并至少部分通过靶向EZH2 / H3K27me3促进肿瘤生长
Ziqiang Tian,Zhenhua Li,Yonggang Zhu et al.
Ziqiang Tian et al.
Local control and dose selection for lung cancer brain metastases treated with radiosurgery: an artificial intelligence model [0.03%]
用于立体定向放射手术治疗肺癌脑转移瘤的局部控制和剂量选择的人工智能模型
Jheremy S Reyes,Alexandros Bouras,Constantinos G Hadjipanayis et al.
Jheremy S Reyes et al.
Clinical and radiological outcomes after Stereotactic radiosurgery (SRS) for lung cancer brain metastases are heterogeneous, and prescription dose selection is often guided by experience rather than individual patient and tumor specific fea...
Integrating single-cell analysis and digital pathology for risk stratification in pancreatic cancer [0.03%]
单细胞分析与数字病理在胰腺癌风险分层中的整合应用研究
Wenhao Bao,Kaiming Leng,Xiaodan Xia et al.
Wenhao Bao et al.
Early liver metastasis is a major factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Single-cell RNA sequencing (scRNA-seq) can analyze the heterogeneity between the primary tumor and metastatic lesions, b...
Matrix and stromal cues cooperatively regulate dormancy-like states of prostate cancer in a dual-niche metastatic model [0.03%]
基质和细胞信号通路合作调节前列腺癌转移双重生态位模型中的休眠态
Bo Han,Zhi Yang,Shuqing Zhao et al.
Bo Han et al.
Prostate cancer (PCa) exhibits a strong tropism for bone, where interactions with the bone microenvironment critically influence metastatic progression and therapeutic resistance. However, the complexity of tumor-bone interactions remains d...
Celine Gergele,Julia Berner,Sander Bekeschus
Celine Gergele