Carcinoembryonic antigen (CEA) and its receptor hnRNP M are mediators of metastasis and the inflammatory response in the liver [0.03%]
癌胚抗原（CEA）及其受体hnRNPM是肝脏转移和炎症反应的介导因子
Peter Thomas,R Armour Forse,Olga Bajenova
Peter Thomas
This article discusses the role of carcinoembryonic antigen (CEA) as a facilitator of the inflammatory response and its effect on colorectal cancer hepatic metastasis. Colorectal cancer accounts for 11% of all cancers in the United States a...
Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells [0.03%]
白细胞介素6受体通过上调卵巢肿瘤细胞甘露糖家族受体LY75的表达促进小鼠腹膜早期种植
Premkumar Vummidi Giridhar,Holly M Funk,Catherine A Gallo et al.
Premkumar Vummidi Giridhar et al.
One of the earliest metastatic events in human ovarian cancer, tumor spread to the omentum, may be influenced by expression of interleukin 6 (IL6) and its cognate receptor (IL6Rα). Previous reports have shown that IL6 and IL6Rα expression...
Ob/ob serum promotes a mesenchymal cell phenotype in B16BL6 melanoma cells [0.03%]
肥胖型2型糖尿病小鼠血清可诱导B16BL6黑色素瘤细胞向间质表型转化
Kyoko Kushiro,Nomelí P Núñez
Kyoko Kushiro
In 2009, malignant melanoma was responsible for approximately 9,000 deaths in the US. These deaths are often associated with aggressive metastasis to secondary sites such as the lungs. Epidemiological and animal studies suggest that obesity...
Arig Ibrahim Hashim,Heather H Cornnell,Maria de Lourdes Coelho Ribeiro et al.
Arig Ibrahim Hashim et al.
The tumor microenvironment is acidic as a consequence of upregulated glycolysis and poor perfusion and this acidity, in turn, promotes invasion and metastasis. We have recently demonstrated that chronic consumption of sodium bicarbonate inc...
Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2 [0.03%]
活性氧介导的蛋白激酶C和整合素信号促进人类肝癌HepG2细胞系的肿瘤进展
Chi-Tan Hu,Jia-Ru Wu,Chuan-Chu Cheng et al.
Chi-Tan Hu et al.
The poor prognosis and recurrence of HCC are majorly caused by intrahepatic metastasis. Delineating the molecular pathways mediating these processes may benefit developing effective targeting therapies. Using human hepatoma HepG2 as a model...
Glycolysis inhibition by 2-deoxy-D-glucose reverts the metastatic phenotype in vitro and in vivo [0.03%]
葡萄糖类似物2-脱氧-D-葡萄糖对糖酵解的抑制可逆转肿瘤细胞的恶性表型
Joseph L Sottnik,Janet C Lori,Barbara J Rose et al.
Joseph L Sottnik et al.
Metastasis is the primary cause of death from many tumors, and novel anti-metastatic therapies are necessary. Recently, we showed that metastatic tumors down-regulate key oxidative phosphorylation (OXPHOS) genes in favor of glycolysis, a fu...
Silencing of CD44 by siRNA suppressed invasion, migration and adhesion to matrix, but not secretion of MMPs, of cholangiocarcinoma cells [0.03%]
siRNA沉默CD44基因抑制胆管癌细胞的侵袭、迁移和黏附，但不影响基质金属蛋白酶的分泌
Pongsanat Pongcharoen,Artit Jinawath,Rutaiwan Tohtong
Pongsanat Pongcharoen
We studied the expression pattern and the role of CD44 in regulating the malignant behavior of two cholangiocarcinoma (CCA) cell lines which expressed different levels of CD44 using the siRNA technique. KKU-100, the high CD44 expresser, exh...
Clinical impact of the tumor volume doubling time on sarcoma patients with lung metastases [0.03%]
肿瘤倍增时间对肺转移肉瘤患者的影响研究
Tomoki Nakamura,Akihiko Matsumine,Takao Matsubara et al.
Tomoki Nakamura et al.
The volume doubling time (VDT) is an accurate and reproducible method for the quantitation of the rate and pattern of tumor growth in individual patients. The purpose of this study is to investigate the tumor VDT using chest CT in individua...
Tumor-stromal interactions of the bone microenvironment: in vitro findings and potential in vivo relevance in metastatic lung cancer models [0.03%]
骨微环境中的肿瘤-基质相互作用：体外发现及其在肺癌转移模型中潜在的体内相关性
Diego Luis-Ravelo,Iker Antón,Silvestre Vicent et al.
Diego Luis-Ravelo et al.
Lung cancer comprises a large variety of histological subtypes with a frequent proclivity to form bone metastasis; a condition associated with dismal prognosis. To identify common mechanisms in the development of osteolytic metastasis, we s...
Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10 [0.03%]
肿瘤细胞来源的TIMP-1通过抑制ADAM-10维持促进转移的Met信号所必需
Florian Schelter,Martina Grandl,Bastian Seubert et al.
Florian Schelter et al.
In many different tumor entities, increased expression of tissue inhibitor of metalloproteinases-1 (Timp-1) is associated with poor prognosis. We previously reported in mouse models that elevated systemic levels of Timp-1 induce a gene expr...