The clinical benefit of adding radiotherapy to ipilimumab in patients with melanoma brain metastasis: a systematic review and meta-analysis [0.03%]
伊匹单抗治疗黑色素瘤脑转移患者时联合放疗的临床获益：系统评价和 Meta 分析
Mohammad Amin Habibi,Pouria Delbari,Farhang Rashidi et al.
Mohammad Amin Habibi et al.
Combining radiotherapy (RT) with Ipilimumab, a CTLA-4 inhibitor, holds promise in treating metastatic brain melanoma (MBM). Despite promising preclinical evidence, clinical studies evaluating their combined efficacy are limited and varied, ...
Spectral computed tomography in the assessment of metastatic lymph nodes in cervical cancer patients treated with definitive radiotherapy: a single-center, prospective study [0.03%]
光谱CT在宫颈癌根治性放疗患者并发病灶评估中的应用价值研究：一项单中心前瞻性研究
Zheng Zeng,Yining Chen,Yuliang Sun et al.
Zheng Zeng et al.
Identifying metastatic lymph nodes (LNs) in patients with cervical cancer treated with definitive radiotherapy may inform treatment strategy and determine prognosis, but available methods have limitations, especially in developing regions. ...
Tumor-to-tumor metastases: systematic review and meta-analysis of 685 reported cases [0.03%]
肿瘤转移至肿瘤内的系统性回顾和meta分析（基于685例报道）
Michał Kunc,Paulina Skrzypkowska,Rafał Pęksa et al.
Michał Kunc et al.
Tumor-to-tumor metastasis is an exceedingly rare phenomenon where secondary deposits of a tumor develops in another one. Our systematic review and meta-analysis aims to uncover and analyze reported cases to enhance our understanding and imp...
Incisional PSMA PET/CT-positive recurrences in prostate cancer- is there an implication on clinical care? [0.03%]
前列腺癌切口PSMA PET/CT阳性复发对临床治疗有影响吗？
Giovanni Mazzucato,Fabian Falkenbach,Jonas Ekrutt et al.
Giovanni Mazzucato et al.
Oligorecurrent prostate cancer (PCa) can be treated with metastasis-directed therapy (MDT), which may be performed using radioguided surgery (RGS) as an experimental approach. These procedures have shown promising outcomes, largely due to t...
Repurposing neuroleptics: clozapine as a novel, adjuvant therapy for melanoma brain metastases [0.03%]
神经精神用药的再利用：氯丙嗪作为新型辅助治疗黑色素瘤脑转移的方法
Tobias Wikerholmen,Erlend Moen Taule,Emma Rigg et al.
Tobias Wikerholmen et al.
The blood-brain barrier and the distinct brain immunology provide challenges in translating commonly used chemotherapeutics to treat intracranial tumors. Previous reports suggest anti-tumoral effects of antipsychotics, encouraging investiga...
m1A-regulated DIAPH3 promotes the invasiveness of colorectal cancer via stabilization of KRT19 [0.03%]
M1A调控的DIAPH3通过稳定KRT19促进结直肠癌侵袭性
Shuyi Mi,Jie Hu,Wenwen Chen et al.
Shuyi Mi et al.
Background: In recent years, the emphasis has shifted to understanding the role of N1-methyladenosine (m1A) in tumor progression as little is known about its regulatory effect on mRNA and its role in the metastasis of col...
Efficacy of radiotherapy in treating local recurrence concomitant with distant metastasis of nasopharyngeal carcinoma: a long-term retrospective multicenter study [0.03%]
放射治疗在局部复发伴远处转移的鼻咽癌患者中的疗效：一项长期多中心回顾性研究
Lu Li,Mingyou Deng,Jianlan Ren et al.
Lu Li et al.
Purpose: Patients with nasopharyngeal carcinoma (NPC) experiencing locoregional recurrence concomitant with distant metastases (rmNPC) after initial treatment represent a unique subgroup with significant management challe...
Multicenter Study
Clinical & experimental metastasis. 2025 Jan 22;42(2):11. DOI:10.1007/s10585-025-10329-2 2025
Metastatic sites and clinical outcomes in renal cell carcinoma patients receiving immune-based combinations: the MOUSEION-08 study [0.03%]
肾细胞癌免疫治疗.MOUSEION-08研究：转移部位与临床结局关系
Alessandro Rizzo,Fernando Sabino Marques Monteiro,Veronica Mollica et al.
Alessandro Rizzo et al.
Immune-based combinations have significantly improved the treatment of metastatic renal cell carcinoma (mRCC); however, immunotherapy has reported varying degrees of efficacy across different metastatic sites, with liver and bone metastases...
Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma reveals the transcriptomic changes underlying denosumab treatment [0.03%]
建立来自肺腺癌骨转移患者的肿瘤类器官 揭示denosumab治疗下的转录组变化
Xianglin Hu,Huajian Wu,Kewen Hu et al.
Xianglin Hu et al.
Patient-derived tumor organoids (PDTOs) models have been widely used to investigate the response of primary cancer tissues to anti-cancer agents. Nonetheless, only few case study tried to establish PDTOs and test treatment response based on...
Pulmonary lysyl oxidase expression and its role in seeding Lewis lung carcinoma cells [0.03%]
肺赖氨氧化酶的表达及其在Lewis肺癌细胞种植中的作用
Kimberly J Jasmer,Vinit C Shanbhag,Kevin Muñoz Forti et al.
Kimberly J Jasmer et al.
Copper promotes tumor growth and metastasis through a variety of mechanisms, most notably as a cofactor within the lysyl oxidase (LOX) family of secreted cuproenzymes. Members of this family, which include LOX and LOX-like enzymes LOXL1-4, ...