Dynamic Bayesian networks for neural information flow: evaluation of continuous and discrete scoring metrics [0.03%]
动态评价神经信息流动的贝叶斯网络：连续和离散评分标准
Jacob Thomas-Hegarty,Stefan R Pulver,V Anne Smith
Jacob Thomas-Hegarty
Neural information flow describes the movement of activity between neurons or brain areas. Advances in experimental methods have allowed production of large amounts of observational data related to neuronal activity from the single-neuron t...
Computational modeling of prefrontal-amygdala circuits links functional connectivity alterations to circuit-level mechanisms in major depression [0.03%]
计算前额叶-杏仁核环路模型揭示抑郁症的功能连接改变源自电路水平机制
Licong Li,Fukuan Zhang,Shuaiyang Zhang et al.
Licong Li et al.
Altered connectivity in the prefrontal cortex-amygdala circuit in Major Depressive Disorder is associated with abnormal circuit states. Although substantial evidence from neuroimaging studies has demonstrated that changes in functional conn...
Stress-associated alterations in amygdala-striatal activity: a multi-level analysis of distributional, dynamical, and computational signatures [0.03%]
与压力相关的杏仁核-纹状体活动变化：分布特征、动力学和计算指标的多水平分析
Feng Lin
Feng Lin
Chronic stress is associated with persistent alterations in neural circuit function, yet how these changes are expressed across multiple descriptive levels remains unclear. Here, we re-analyzed in vivo GCaMP8s recordings from BLA-DMS and Ce...
Hierarchical learning creates invariant schema within plastic neural networks [0.03%]
层次学习在类脑可塑性神经网络中构造不变模式
James R Elder,Jie Zheng,Lydia B Shimelis et al.
James R Elder et al.
Cognitive neural circuits must balance the plasticity needed for continual learning with the stability needed to preserve an underlying reasoning framework, called a schema. How circuit learning rules form and protect such schemata from bei...
Intrinsic chaos control in cortical circuits: A minimal E-I-M rate model for primary visual cortex [0.03%]
皮质回路中的固有混沌控制：主视觉皮层的最小EI-M率模型
Mehdi Borjkhani,Morteza A Sharif,Hadi Borjkhani
Mehdi Borjkhani
Cortical circuits exhibit variable yet bounded activity patterns, suggesting operation near-but not within-fully chaotic regimes. Here we develop a minimal three-variable rate model for primary visual cortex (V1) that reveals how biological...
Modeling developmental spiking behavior driven by ionic current dynamics of mouse and human inner hair cells using a calcium-enhanced Izhikevich framework [0.03%]
基于钙增强的Izhikevich框架模拟小鼠和人的内毛细胞离子电流动力学驱动的发育性尖峰行为
Sneha Singh,Biswajit Das,Soumik Roy
Sneha Singh
Hearing loss (HL) is the third leading cause of years lived with disability worldwide, underscoring the critical need for comprehensive research to unravel the developmental mechanisms that shape auditory function. This work presents a biol...
A biophysically grounded model of glutamatergic synaptic transmission integrating glutamate transport, receptor kinetics, and electrotonic effects [0.03%]
一种基于生物物理的谷氨酸能突触传递模型，整合了谷氨酸转运、受体动力学和电位效应
A V Chizhov,S L Malkin,D N Khachatryan et al.
A V Chizhov et al.
Gluatamatergic synaptic transmission, critical for learning and memory, relies on precise regulation of extracellular glutamate levels by astrocytic transporters, particularly EAAT2. While existing models of AMPA and NMDA receptor kinetics ...
When can neuronal activity-dependent homeostatic plasticity maintain circuit-level properties? [0.03%]
什么样的神经元活性依赖的稳态可塑性能保持电路水平的性质？
Lindsay J Stolting,Randall D Beer
Lindsay J Stolting
Neural circuits are remarkably robust to perturbations that threaten their function. Activity-dependent homeostatic plasticity (ADHP) is a stabilizing mechanism that supports robustness by tuning neuronal ion conductances to combat chronic ...
A charge conservative finite volume discretization of the Hodgkin-Huxley model [0.03%]
一种Hodgkin-Huxley模型的电荷保守型有限体积离散格式
Muhammad Zeeshan Ashraf,Tanel Peets,Kert Tamm
Muhammad Zeeshan Ashraf
This article presents a computational study of the Hodgkin-Huxley model and the simulation of action potential propagation in an unmyelinated axon using the finite volume method. By implementing a voltage-clamp patch and tracking detailed i...
Bidirectional Hopf bifurcation control of narrowband gamma oscillations in Parkinson's disease by the corticothalamic system via non-canonical pathways [0.03%]
皮层-丘脑系统通过非经典通路控制帕金森病窄带gamma振荡的双向Hopf分岔现象
Bing Hu,Ruoyi Fan,Shinan Chen et al.
Bing Hu et al.
Gamma oscillation ([Formula: see text]) is an important neuronal rhythmic activity closely related to various brain functions, such as Parkinson's disease (PD). By identifying several direct glutamatergic projections from the cortical-thala...