Correction to: Human artificial chromosome carrying 3p21.3‑p22.2 region suppresses hTERT transcription in oral cancer cells [0.03%]
口服癌细胞中携带3p21.3-p22.2区域的人工染色体对hTERT转录具有抑制作用纠正版
Takahito Ohira,Kaho Yoshimura,Hiroyuki Kugoh
Takahito Ohira
Anouk van den Brink,Maria F Suárez Peredo Rodríguez,Floris Foijer
Anouk van den Brink
Chromosomal instability (CIN), an increased rate of chromosomal segregation abnormalities, drives intratumor heterogeneity and affects most human cancers. In addition to chromosome copy number alterations, CIN results in chromosome(s) (frag...
Twenty years of merotelic kinetochore attachments: a historical perspective [0.03%]
染色单体异侧附着研究的历史回顾——二十年的成果与展望
Daniela Cimini
Daniela Cimini
Micronuclei, small DNA-containing structures separate from the main nucleus, were used for decades as an indicator of genotoxic damage. Micronuclei containing whole chromosomes were considered a biomarker of aneuploidy and were believed to ...
Human artificial chromosome carrying 3p21.3-p22.2 region suppresses hTERT transcription in oral cancer cells [0.03%]
携带人类3号染色体21.3-22.2区域的人工染色体通过抑制口腔癌细胞中hTERT转录发挥作用
Takahito Ohira,Kaho Yoshimura,Hiroyuki Kugoh
Takahito Ohira
Telomerase is a ribonucleoprotein ribonucleic enzyme that elongates telomere repeat sequences at the ends of chromosomes and contributes to cellular immortalization. The catalytic component of telomerase, human telomerase reverse transcript...
Chromosomal conservatism vs chromosomal megaevolution: enigma of karyotypic evolution in Lepidoptera [0.03%]
染色体守恒与大规模染色体进化事件：鳞翅目染色体演化之谜
Elena A Pazhenkova,Vladimir A Lukhtanov
Elena A Pazhenkova
In the evolution of many organisms, periods of slow genome reorganization (= chromosomal conservatism) are interrupted by bursts of numerous chromosomal changes (= chromosomal megaevolution). Using comparative analysis of chromosome-level g...
Mechanisms of chromosomal instability (CIN) tolerance in aggressive tumors: surviving the genomic chaos [0.03%]
癌基因型不稳定性(CIN)在恶性肿瘤中的耐受机制——适应基因组混乱状态生存下来
Brittiny Dhital,Veronica Rodriguez-Bravo
Brittiny Dhital
Chromosomal instability (CIN) is a pervasive feature of human cancers involved in tumor initiation and progression and which is found elevated in metastatic stages. CIN can provide survival and adaptation advantages to human cancers. Howeve...
Chromosome-length genome assemblies and cytogenomic analyses of pangolins reveal remarkable chromosome counts and plasticity [0.03%]
泛基因组与染色体水平山豪猪基因组分析揭示了其染色体数目及高度的染色体多态性
Marlys L Houck,Klaus-Peter Koepfli,Taylor Hains et al.
Marlys L Houck et al.
We report the first chromosome-length genome assemblies for three species in the mammalian order Pholidota: the white-bellied, Chinese, and Sunda pangolins. Surprisingly, we observe extraordinary karyotypic plasticity within this order and,...
An essential role for the Ino80 chromatin remodeling complex in regulation of gene expression during cellular quiescence [0.03%]
Ino80染色质重塑复合物在细胞静止期基因表达调控中的重要作用
Yasaman Zahedi,Shengyuan Zeng,Karl Ekwall
Yasaman Zahedi
Cellular quiescence is an important physiological state both in unicellular and multicellular eukaryotes. Quiescent cells are halted for proliferation and stop the cell cycle at the G0 stage. Using fission yeast as a model organism, we have...
Characterization of centromeric DNA of Gossypium anomalum reveals sequence-independent enrichment dynamics of centromeric repeats [0.03%]
Gossypium anomalum的着丝粒DNA特征分析揭示了着丝粒重复序列独立富集动力学规律
Wenjie Ding,Yuanbin Zhu,Jinlei Han et al.
Wenjie Ding et al.
Centromeres in eukaryotes are composed of highly repetitive DNAs, which evolve rapidly and are thought to achieve a favorable structure in mature centromeres. However, how the centromeric repeat evolves into an adaptive structure is largely...
A Cre-LoxP-based approach for combinatorial chromosome rearrangements in human HAP1 cells [0.03%]
基于Cre-LoxP的人类HAP1细胞组合染色体重排的方法
Anna Khabarova,Galina Koksharova,Pavel Salnikov et al.
Anna Khabarova et al.
Alterations of human karyotype caused by chromosomal rearrangements are often associated with considerable phenotypic effects. Studying molecular mechanisms underlying these effects requires an efficient and scalable experimental model. Her...