Comparative analysis of repetitive DNA in dysploid and non-dysploid Phaseolus beans [0.03%]
异倍体和非异倍体芸豆的重复序列DNA比较分析
Maria Eduarda Ferraz,Tiago Ribeiro,Mariela Sader et al.
Maria Eduarda Ferraz et al.
Structural karyotype changes result from ectopic recombination events frequently associated with repetitive DNA. Although most Phaseolus species present relatively stable karyotypes with 2n = 22 chromosomes, the karyotypes of species of the...
MicrosatNavigator: exploring nonrandom distribution and lineage-specificity of microsatellite repeat motifs on vertebrate sex chromosomes across 186 whole genomes [0.03%]
微卫星导航员：探索脊椎动物性染色体上简单序列重复在186个基因组中的非随机分布和谱系特异性
Ryan Rasoarahona,Pish Wattanadilokchatkun,Thitipong Panthum et al.
Ryan Rasoarahona et al.
Microsatellites are short tandem DNA repeats, ubiquitous in genomes. They are believed to be under selection pressure, considering their high distribution and abundance beyond chance or random accumulation. However, limited analysis of micr...
Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies [0.03%]
染色体非整倍性、染色体不稳定性以及肿瘤异质性在癌症治疗耐药性发展中的作用机制研究
Joana Reis Andrade,Annie Dinky Gallagher,Jovanna Maharaj et al.
Joana Reis Andrade et al.
Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy can be present in a static state: Down syndrome individuals ...
Analog-sensitive Cdk1 as a tool to study mitotic exit: protein phosphatase 1 is required downstream from Cdk1 inactivation in budding yeast [0.03%]
模拟敏感的Cdk1作为研究有丝分裂退出的工具：蛋白磷酸酶1在酵母芽殖酵母中的失活位于Cdk1下游
Jason M Keaton,Benjamin G Workman,Linfeng Xie et al.
Jason M Keaton et al.
We show that specific inactivation of the protein kinase Cdk1/cyclin B (Cdc28/Clb2) triggers exit from mitosis in the budding yeast Saccharomyces cerevisiae. Cells carrying the allele cdc28-as1, which makes Cdk1 (Cdc28) uniquely sensitive t...
Meiotic segregation and post-meiotic drive of the Festuca pratensis B chromosome [0.03%]
意大利黑麦草B染色体的减数分裂分离及后减数分裂驱动效应
Rahman Ebrahimzadegan,Jörg Fuchs,Jianyong Chen et al.
Rahman Ebrahimzadegan et al.
In many species, the transmission of B chromosomes (Bs) does not follow the Mendelian laws of equal segregation and independent assortment. This deviation results in transmission rates of Bs higher than 0.5, a process known as "chromosome d...
Modeling specific aneuploidies: from karyotype manipulations to biological insights [0.03%]
染色体作图操作与生物学新认识的模拟特定异倍体问题
My Anh Truong,Paula Cané-Gasull,Susanne M A Lens
My Anh Truong
An abnormal chromosome number, or aneuploidy, underlies developmental disorders and is a common feature of cancer, with different cancer types exhibiting distinct patterns of chromosomal gains and losses. To understand how specific aneuploi...
Eduardo M Torres
Eduardo M Torres
Mistakes in chromosome segregation leading to aneuploidy are the primary cause of miscarriages in humans. Excluding sex chromosomes, viable aneuploidies in humans include trisomies of chromosomes 21, 18, or 13, which cause Down, Edwards, or...
Replication stress causes delayed mitotic entry and chromosome 12 fragility at the ANKS1B large neuronal gene in human induced pluripotent stem cells [0.03%]
端螺旋体导致人类诱导多能干细胞中ANKS1B大型神经元基因染色体12片段丢失和有丝分裂延迟
Anastasiia V Kislova,Diana Zheglo,Victoria O Pozhitnova et al.
Anastasiia V Kislova et al.
Substantial background level of replication stress is a feature of embryonic and induced pluripotent stem cells (iPSCs), which can predispose to numerical and structural chromosomal instability, including recurrent aberrations of chromosome...
Genome composition in Brassica interspecific hybrids affects chromosome inheritance and viability of progeny [0.03%]
芸苔属种间杂种的基因组构成影响染色体遗传和后代存活率
Elvis Katche,Elizabeth Ihien Katche,Paula Vasquez-Teuber et al.
Elvis Katche et al.
Interspecific hybridization is widespread in nature and can result in the formation of new hybrid species as well as the transfer of traits between species. However, the fate of newly formed hybrid lineages is relatively understudied. We un...
Exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instability [0.03%]
利用活体生物样本库来确定疾病特异性染色体不稳定的机制
Louisa Nelson,Bethany M Barnes,Anthony Tighe et al.
Louisa Nelson et al.
Chromosome instability (CIN) is a cancer hallmark that drives tumour heterogeneity, phenotypic adaptation, drug resistance and poor prognosis. High-grade serous ovarian cancer (HGSOC), one of the most chromosomally unstable tumour types, ha...