Low-coverage whole-genome sequencing for differentiating cervical cancer from cervical intraepithelial neoplasia and benign diseases [0.03%]
低覆盖全基因组测序鉴别宫颈癌与宫颈上皮内瘤变和良性疾病
Tingting Zhang,Fang Gu,Jia Yi He et al.
Tingting Zhang et al.
Objectives: This study aimed to analyze chromosomal arm-level copy number variations (CNVs) in benign diseases, cervical intraepithelial neoplasia (CIN), and cervical cancer (CC) using low-coverage whole genome sequencing...
Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure [0.03%]
高压下传统核小体和CENP-A核小体的可逆变形凸显了两者构象的区别
Kushol Gupta,Nikolina Sekulić,Praveen Kumar Allu et al.
Kushol Gupta et al.
Solution-based interrogation of the physical nature of nucleosomes has its roots in X-ray and neutron scattering experiments, including those that provided the initial observation that DNA wraps around core histones. In this study, we perfo...
Appearance of transient heteromorphic large chromosome in glyphosate-resistant Amaranthus tuberculatus [0.03%]
抗草甘膦粗糙黎的暂时性异形大染色体现象
Rajendran Sathishraj,Yoonha Ju,Bikram S Gill et al.
Rajendran Sathishraj et al.
Glyphosate resistance in crop weeds is commonly attributed to rapid evolution through the amplification of the target gene, EPSPS (5-enolpyruvylshikimate-3-phosphate synthase). This amplification typically occurs through mechanisms such as ...
Miriama Štiavnická,Rachel S Keegan,Elaine M Dunleavy
Miriama Štiavnická
During spermiogenesis, histones are removed from most genomic loci and are replaced by protamines in mature sperm nuclei. Yet, centromeres appear resistant to this process. We review the experimental evidence that the centromeric histone CE...
CRISPR-CISH: an in situ chromogenic DNA repeat detection system for research and life science education [0.03%]
一种用于科学研究和生命科学教育的原位彩色核酸重复检测系统(CRISPR-CISH)
Bhanu Prakash Potlapalli,Fabian Dassau,Jörg Fuchs et al.
Bhanu Prakash Potlapalli et al.
In situ hybridization is a technique to visualize specific DNA sequences within nuclei and chromosomes. Various DNA in situ fluorescent labeling methods have been developed, which typically involve global DNA denaturation prior to the probe...
The landscape of transposable element distribution in the genome of Neotropical fish Apareiodon sp. (Characiformes: Parodontidae) [0.03%]
南美鱼类Apareiodon属基因组的转座元件分布格局( Characiformes：Parodontidae)
Fernanda Souza de Oliveira,Toby Brann,Ivan Rodrigo Wolf et al.
Fernanda Souza de Oliveira et al.
Transposable elements (TEs) are widely present in eukaryotic genomes, where they can contribute to genome size and functional modifications. As new genomes are sequenced and annotated, more studies can be conducted regarding TE content, dis...
TOP2B is required for compartment strength changes upon retinoic acid treatment in SH-SY5Y cells [0.03%]
TOP2B对SH-SY5Y细胞中视黄酸处理引起的区室强度变化是必需的
Erica M Hildebrand,Ian G Cowell,Mushtaq M Khazeem et al.
Erica M Hildebrand et al.
DNA topoisomerase II beta (TOP2B) is required for correct execution of certain developmental transcriptional programs and for signal-induced transcriptional activation, including transcriptional activation by nuclear hormone ligands such as...
First prenatal case of jumping-like translocations: unraveling complex chromosomal rearrangements [0.03%]
首例产前跳跃样易位：解析复杂染色体重排
Kevin Cassinari,Anne Claire Brehin,Ferdi Kundul et al.
Kevin Cassinari et al.
Jumping translocations and jumping-like translocations constitute a rare category of complex chromosomal rearrangements, which are primarily observed in hematologic disorders and solid tumors. This study outlines a complex structural mosaic...
D Dedukh,T Kulikova,M Dobrovolskaia et al.
D Dedukh et al.
Danio rerio, commonly known as zebrafish, is an established model organism for the developmental and cell biology studies. Although significant progress has been made in the analysis of the D. rerio genome, cytogenetic studies face challeng...
Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle [0.03%]
细胞周期中染色体沿中心体和顶基轴的单侧运动限制
Pingping Cai,Christian J Casas,Gabriel Quintero Plancarte et al.
Pingping Cai et al.
Little is known about how distance between homologous chromosomes are controlled during the cell cycle. Here, we show that the distribution of centromere components display two discrete clusters placed to either side of the centrosome and a...