The dynamic centromere [0.03%]
动态着丝粒
Angela Enriquez,Yael Nechemia-Arbely
Angela Enriquez
Centromeres are fundamental chromosomal structures that ensure accurate chromosome segregation during cell division. Despite their conserved and essential role in maintaining genomic stability, centromeres are subject to rapid evolutionary ...
Preserving centromere identity: right amounts of CENP-A at the right place and time [0.03%]
维持着丝粒特异性：正确的CENP-A数量在正确的位置和时间出现
Zofia Pukało,Bethan Medina-Pritchard,Maria Alba Abad et al.
Zofia Pukało et al.
Four decades ago, the discovery of centromere protein-A (CENP-A) marked a pivotal breakthrough in chromosome biology, revealing the epigenetic foundation of centromere identity. CENP-A, a histone H3 variant, directs the formation of the mic...
CENP-A is diluted during bovine spermatogenesis and is maintained at internally positioned centromere clusters in mature bull sperm [0.03%]
牛精子发生过程中CENP-A被稀释并在成熟公牛精子内部定位的着丝粒簇中得到维持
Miriama Štiavnická,Anna Ní Nualláin,Caitríona M Collins et al.
Miriama Štiavnická et al.
During spermatogenesis, chromatin structure is remodelled by the incorporation of distinct histone variants and associated posttranslational modifications, followed by the almost complete replacement of histones by protamines in sperm. Howe...
Annapaola Angrisani,Daniele Fachinetti
Annapaola Angrisani
The centromere is a region present on every human chromosome that is essential for mediating chromosome segregation and maintaining genome stability. However, despite its fundamental role in the process of cell division, the centromere is c...
Fungi as models of centromere innovation: from DNA sequence to 3-dimensional arrangement [0.03%]
从DNA序列到三维排列：作为核心粒创新模型的真菌
Srijana Dutta,Krishna Bhat,Rashi Aggarwal et al.
Srijana Dutta et al.
Faithful chromosome segregation is facilitated by the centromeres, specialized genomic loci, which connect chromosomes to microtubules in every cell cycle by recruiting the kinetochore complex. However, a single conserved code does not gove...
Paul B Talbert,Steven Henikoff
Paul B Talbert
The identification of CENPA, CENPB, and CENPC by Earnshaw and Rothfield 40 years ago has revealed the remarkable diversity and complexity of centromeres and confirmed most seed plants and animals have centromeres comprised of complex satell...
Sterility and structural variation in an arabidopsis pedigree carrying a ring minichromosome [0.03%]
携带环状微染色体的拟南芥系中不育性和结构变异性的研究
Benny Ordoñez,Weier Guo,Witsarut Chueakhunthod et al.
Benny Ordoñez et al.
Circular minichromosomes could be useful tools for plant biotechnology, yet their long-term structural stability, heritability, and effects on phenotype remain poorly understood. In this study, we report a multi-generational analysis of the...
A brief historical perspective on cell cycle control of CENP-A assembly and inheritance [0.03%]
从历史角度简述细胞周期控制CENP-A装配和遗传的作用机制
Grant Rowley,Lars E T Jansen
Grant Rowley
Centromeres provide the chromosomal scaffold for the assembly of the kinetochore complex, thereby linking replicated sister chromatids to the mitotic spindle, driving their segregation into nascent daughter cells. The location and maintenan...
Centromeres in the thermotolerant yeast K. marxianus mediate attachment to a single microtubule [0.03%]
耐热酵母K.marrowiani的着丝粒与单个微管相连
Daniel J Barrero,Sabrine Hedouin,Yizi Mao et al.
Daniel J Barrero et al.
Eukaryotic chromosome segregation requires spindle microtubules to attach to chromosomes through kinetochores. The chromosomal locus that mediates kinetochore assembly is the centromere and is epigenetically specified in most organisms by a...
Eleonora Cappelletti,Francesca M Piras,Marialaura Biundo et al.
Eleonora Cappelletti et al.
While the centromeric function is conserved and epigenetically specified by CENP-A, centromeric DNA, typically composed of satellite repeats, is highly divergent and rapidly evolving. In the species of the genus Equus (horses, asses and zeb...