Damian Dudka,Michael A Lampson
Damian Dudka
Centromeres connect chromosomes and spindle microtubules to ensure faithful chromosome segregation. Paradoxically, despite this conserved function, centromeric DNA evolves rapidly and centromeric proteins show signatures of positive selecti...
Comparative cytogenomics reveals genome reshuffling and centromere repositioning in the legume tribe Phaseoleae [0.03%]
比较细胞基因组学揭示了豆科植物族Phaseoleae中的基因组重组和着丝粒重新定位
Claudio Montenegro,Lívia do Vale Martins,Fernanda de Oliveira Bustamante et al.
Claudio Montenegro et al.
The tribe Phaseoleae includes several legume crops with assembled genomes. Comparative genomic studies have evidenced the preservation of large genomic blocks among legumes, although chromosome dynamics during Phaseoleae evolution has not b...
Menghan Li,Shuyue Li,Yan He et al.
Menghan Li et al.
Most plant species have three or more SPO11/TOPOVIA homologs and two TOPOVIB homologs, which associate to trigger meiotic double-strand break (DSB) formation and subsequent meiotic recombination. In Zea mays L. (maize), ZmSPO11-1 and ZmMTOP...
Juan Pedro M Camacho
Juan Pedro M Camacho
Selfish genetic elements (SGE) get a transmission advantage (drive) thanks to their non-Mendelian inheritance. Here I identify eight steps during the reproductive cycle that can be subverted by SGEs to thrive in natural populations. Even th...
R Kelly Dawe
R Kelly Dawe
The maize abnormal chromosome 10 (Ab10) haplotype encodes a meiotic drive system that converts heterochromatic knobs into centromere-like bodies that are preferentially segregated through female meiosis. Ab10 was first described in the 1940...
A meiotic driver alters sperm form and function in house mice: a possible example of spite [0.03%]
拟雌核遗传因子通过改变小家鼠精子的形态和功能而降低异配个体的适应性：可能的“恶意竞争”现象的一个例证
Lennart Winkler,Anna K Lindholm
Lennart Winkler
The ability to subvert independent assortment of chromosomes is found in many meiotic drivers, such as the t haplotype in house mice Mus musculus, in which the t-bearing chromosomal homolog is preferentially transmitted to offspring. This i...
The fate of a suppressed X-linked meiotic driver: experimental evolution in Drosophila simulans [0.03%]
里氏麦氏锥虫的一个抑制的X染色体雄性扭曲基因的命运：模拟果蝇的实验进化研究
Héloïse Bastide,David Ogereau,Catherine Montchamp-Moreau et al.
Héloïse Bastide et al.
Sex-ratio (SR) meiotic drivers are X-linked selfish genetic elements that promote their own transmission by preventing the production of Y-bearing sperm, which usually lowers male fertility. The spread of SR drivers in populations is expect...
Meiotic pairing and double-strand break formation along the heteromorphic threespine stickleback sex chromosomes [0.03%]
异形三刺鱼性染色体的联会和双链断裂形成
Shivangi Nath,Lucille A Welch,Mary K Flanagan et al.
Shivangi Nath et al.
Double-strand break repair during meiosis is normally achieved using the homologous chromosome as a repair template. Heteromorphic sex chromosomes share little sequence homology, presenting unique challenges to the repair of double-strand b...
Alternative end-joining originates stable chromosome aberrations induced by etoposide during targeted inhibition of DNA-PKcs in ATM-deficient tumor cells [0.03%]
ATM缺陷型肿瘤细胞靶向抑制DNA-PKcs时依托泊苷诱发的替代末端连接介导稳定的染色体畸变
Marcelo de Campos Nebel,Micaela Palmitelli,Josefina Pérez Maturo et al.
Marcelo de Campos Nebel et al.
ATM and DNA-PKcs coordinate the DNA damage response at multiple levels following the exposure to chemotherapy. The Topoisomerase II poison etoposide (ETO) is an effective chemotherapeutic agent that induces DNA double-strand breaks (DSB), b...
A cryo-fixation protocol to study the structure of the synaptonemal complex [0.03%]
用于研究联会复合体结构的冷冻固定方法
Rosario Ortiz,Olga M Echeverría,Sergej Masich et al.
Rosario Ortiz et al.
Genetic variability in sexually reproducing organisms results from an exchange of genetic material between homologous chromosomes. The genetic exchange mechanism is dependent on the synaptonemal complex (SC), a protein structure localized b...