Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress [0.03%]
缺氧糖酵解驱动的组蛋白乳酸化通过COX6C介导的内质网应激激活NHE7促进子宫内膜癌进展
Shizhou Yang,Tingting Wu,Zhu Cao et al.
Shizhou Yang et al.
Background: Endometrial Cancer (EC) is one of the most prevalent malignancies in the female reproductive system. Hypoxia is a hallmark of the tumor microenvironment that drives metabolic reprogramming, endoplasmic reticul...
Enhancing the efficacy of VEGF inhibitors by co-inhibition of HIF in the treatment of glioblastoma [0.03%]
通过联合抑制HIF增强VEGF抑制剂在胶质母细胞瘤治疗中的疗效
Emirhan Harbi,Yasemin Yozgat Byrne,Hamza Ugur Bozbey et al.
Emirhan Harbi et al.
Glioblastoma is the most aggressive and most common grade 4 tumor of the central nervous system (CNS). Despite standard treatments such as surgical resection and chemoradiotherapy, overall survival (OS) usually does not exceed 14-16 months ...
Xiangyi Li,Yan Zhao,Xuegang Zhao et al.
Xiangyi Li et al.
Sepsis has a high morbidity and mortality rate, and effective therapeutic options remain limited. Lipopolysaccharide (LPS) is known to induce significant changes in the expression of forkhead box O (FOXO) transcription factor family members...
BMP7 attenuates myocardial injury and preserves cardiac function after myocardial infarction by inhibiting cardiomyocyte pyroptosis [0.03%]
BMP7通过抑制心肌细胞焦亡减轻心肌梗死后的心肌损伤和保护心脏功能
Maojun Liu,Junyu Pei,Cheng Zeng et al.
Maojun Liu et al.
Myocardial injury and adverse remodeling following acute myocardial infarction (MI) drive heart failure progression, in which cardiomyocyte pyroptosis plays a critical pathogenic role. Bone morphogenetic protein 7 (BMP7) exerts anti-fibroti...
ILF2 cooperates with ILF3/KLF16 to drive colorectal cancer progression via modulating the behaviors of both tumor cells and M2 macrophages [0.03%]
ILF2通过调节肿瘤细胞和M2巨噬细胞的行为来驱动结直肠癌进展(ILF2与ILF3/KLF16合作)
Dong Mao,Jufeng Sun,Xiaowei Zhang et al.
Dong Mao et al.
Colorectal cancer (CRC) is a malignant tumor originating from the epithelial cells of the colon and rectum. Interleukin enhancer binding factor 2 (ILF2), an emerging RNA-binding protein, has been implicated in the regulation of multiple can...
The cGAS-STING pathway in fibroblast microenvironment: from molecular mechanisms to targeted therapies [0.03%]
成纤维细胞微环境中的cGAS-STING通路：从分子机制到靶向治疗
Zhe Zhang,Huidan Deng,Xiyuan Zhang et al.
Zhe Zhang et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway serves as a core signaling axis for sensing cytosolic DNA and activating innate immunity. By recognizing abnormal DNA released from pathogens or tissue damage...
Targeting PANoptosis in atherosclerosis: bridging cell death mechanisms and therapy [0.03%]
动脉粥样硬化中靶向PANoptosis：连接细胞死亡机制和治疗
Lanqing Hu,Changxin Sun,Xiaoya Li et al.
Lanqing Hu et al.
Zi-Zhan Li,Tian-Fu Wu,Zhi-Jun Sun
Zi-Zhan Li
Cancer treatment remains in need of novel therapeutic strategies to improve patient outcomes. Cuproptosis, a recently identified form of immunogenic cell death, is recognized for its significant anticancer potential. However, most cuproptos...
Beyond the hype: the glycolysis-pyroptosis axis in intervertebral disc degeneration and the path to therapeutic translation [0.03%]
拨开迷雾：糖酵解-焦亡轴在椎间盘退变中的作用及治疗转化路径
DuJiang Yang,Jiexiang Yang,GuoYou Wang
DuJiang Yang
The recent study by Gao et al. (Apoptosis, 2025. https://doi.org/10.1007/s10495-025-02194-x ) proposes a compelling paradigm in which a positive feedback loop between glycolysis and nucleus pulposus cell pyroptosis acts as a central driver ...
Monocyte-mediated mechanisms in idiopathic pulmonary fibrosis: opportunities for early intervention [0.03%]
特发性肺纤维化中单核细胞介导的机制：早期干预的机会
Zhiguo Mao,Ying Liu,Chengfu Han et al.
Zhiguo Mao et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease marked by irreversible deposition of the extracellular matrix (ECM) and subsequent disruption of pulmonary architecture. Although current pharmacological interventio...