Cell death and its interaction with mitochondrial dysfunction in pathogenesis of acute pancreatitis: a comprehensive review [0.03%]
急性胰腺炎发病过程中细胞死亡及其与线粒体功能障碍的相互作用：综述
Jiayi Zhang,Hanwen Chen,Yanhong Wang et al.
Jiayi Zhang et al.
Acute pancreatitis (AP) is a potentially life-threatening inflammatory disease whose severity is fundamentally shaped by the mode of pancreatic acinar cell death. Crucially, this cell fate decision is primarily governed by genetically encod...
Cell adhesion molecules as emerging regulators of ferroptosis: mechanisms and therapeutic opportunities in cancer [0.03%]
细胞粘附分子作为铁死亡的新兴调节因子：癌症中铁死亡的机制和治疗机会
Shiwen Liu,Li Fang,Haoran Suo et al.
Shiwen Liu et al.
Ferroptosis represents an iron-dependent form of regulated cell death, distinguished by the accumulation of lipid peroxides. This process holds significant implications for tumor progression and resistance to therapeutic interventions. Cell...
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy [0.03%]
清除治疗诱导的衰老癌细胞针对并增强胰腺癌细胞对PARP抑制剂维持治疗的反应
Yupeng Li,Zhangjun Jia,Xiaolin Liu et al.
Yupeng Li et al.
Poly (ADP‒ribose) polymerase inhibitors (PARPis) are widely used in maintenance therapy for various platinum-sensitive cancers regardless of the occurrence of BRCA mutations. However, the mechanisms of action and treatment resistance assoc...
Ferroptosis in salivary gland disorders: mechanisms, biomarkers, and therapeutic perspectives [0.03%]
铁死亡在唾液腺疾病中的作用：机制、生物标志物和治疗前景
Jaewang Lee,Jong-Lyel Roh
Jaewang Lee
Ferroptosis-centered strategies: redefining therapeutic resistance & adaptation in modern oncology [0.03%]
以铁死亡为中心的策略：在现代肿瘤学中重新定义治疗抵抗与适应
Dineshkumar Madappan,Madhu Bommenahalli Krishnegowda,Prasiddhi Naik et al.
Dineshkumar Madappan et al.
Ferroptosis is a new regulated cell death process, independent of apoptosis, necroptosis, and pyroptosis, which offers a promising therapeutic opportunity characterised by iron-dependent lipid peroxidation and mitochondrial membrane condens...
SEMA3E promotes beige adipocyte differentiation and thermogenesis via β-catenin signaling in mice [0.03%]
SEMA3E通过β-连环蛋白信号促进小鼠 beige 脂肪细胞分化和产热
Chenxi Xiao,Zhenghua Su,Jialin Zhao et al.
Chenxi Xiao et al.
Beige adipocytes play a key role in non-shivering thermogenesis. SEMA3E, a member of the class 3 semaphorin family, is involved in various pathological processes, but its role in adipocyte differentiation and thermogenesis remains unclear. ...
CD95 ligand drives abdominal aortic aneurysm progression through Caspase-8-mediated GSDMD-dependent endothelial pyroptosis: modulation by SRC kinase [0.03%]
CD95配体通过Caspase-8介导的GSDMD依赖性的内皮细胞焦亡促进腹主动脉瘤进展：由SRC激酶调节
Tian-Tian Ke,Chuan Yuan,Yong Yuan et al.
Tian-Tian Ke et al.
Abdominal aortic aneurysm (AAA) progression is closely linked to inflammation and endothelial dysfunction. Our previous study has demonstrated that increased CD95 ligand (CD95L) and its downstream effector Caspase-8 in the aortic tissue, co...
VDAC2: an emerging pivotal and multifaceted regulator in tumor biology [0.03%]
VDAC2：肿瘤生物学中的一个新兴的多功能调节因子
Jianqiao Shentu,Hening Xu,Ling Jin et al.
Jianqiao Shentu et al.
Voltage-dependent anion channel 2 (VDAC2) is a pivotal β-barrel protein located in the mitochondrial outer membrane (MOM), playing a central role in metabolite transport, ion homeostasis, and the determination of cell fate. Compared to oth...
Cell death and immune escape in the tumor microenvironment: associated mechanisms, opportunities and challenges [0.03%]
肿瘤微环境中细胞死亡与免疫逃逸：相关机制、机遇及挑战
Jincai Guo,Ya Liu,Ying Huang et al.
Jincai Guo et al.
The tumor microenvironment (TME) is a dynamic and complex biological system composed of cancer cells, stromal cells, fibroblasts, immune cells, extracellular matrix, and tumor vasculature. It plays a pivotal role in tumor initiation, progre...
NAC and DNase I synergistically reduce NETs to attenuate severe acute pancreatitis via suppressing the NETs/NF-κB/CXCL3 pathway [0.03%]
NAC和DNase I通过抑制NETs/NF-κB/CXCL3通路协同减少NETs以减轻急性重症胰腺炎
Binjie Li,Pengpeng Liu,Xuewu Yang et al.
Binjie Li et al.
Neutrophil extracellular traps (NETs) drive severe acute pancreatitis (SAP) progression by promoting pancreatic injury, duct obstruction, and systemic inflammation. Reactive oxygen species (ROS) are critical for NETs formation, while NETs d...