Spatially gated oxidative killing: mitoxyperilysis redefines how ROS cause lytic cell death [0.03%]
空间门控氧化性细胞杀伤：Mitoxyperilysis重新定义活性氧的溶细胞性死亡机制
Meng-Yu Wu,Andy P Tsai,Su-Boon Yong et al.
Meng-Yu Wu et al.
The landscape of regulated cell death (RCD) has expanded substantially over the past decade, extending beyond the classic apoptosis-necrosis dichotomy to encompass a diverse array of lytic modalities, including pyroptosis, necroptosis, and ...
Breast cancer: taxonomy, distribution analysis, risk factors, predictive biomarkers, and modern treatment method [0.03%]
乳腺癌：分类、分布分析、危险因素、预测生物标志物及现代治疗方法
Abhiroop Sengupta,Parasmita Saha,Ritama Chakraborty et al.
Abhiroop Sengupta et al.
Aquaporin-1 stabilizes β-catenin to promote NLRP3 inflammasome-mediated pyroptosis in rheumatoid arthritis [0.03%]
水通道蛋白-1通过稳定β-catenin促进类风湿关节炎中NLRP3炎性小体介导的细胞焦亡
Meng-Yuan Zhou,Zi-Yao Gao,Jing Sun et al.
Meng-Yuan Zhou et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by synovial inflammation and joint damage, with fibroblast-like synoviocytes (FLS) acting as key drivers of RA pathogenesis. Pyroptosis, a form of inflammatory programmed cel...
Neural stem cell-derived exosomal PA2G4 induces ANXA2 degradation to promote mitophagy and alleviate neuronal oxidative stress in cerebral ischemia/reperfusion [0.03%]
神经干细胞源性外泌体PA2G4诱导ANXA2降解促进线粒体自噬缓解脑缺血再灌注氧化应激损伤
Mingming Dai,Tingting Lu,Jinghao Li et al.
Mingming Dai et al.
Cerebral ischemia/reperfusion injury (CI/RI) is a common complication of cerebrovascular diseases such as stroke, characterized by mitochondrial dysfunction. This study investigates the function of proliferation-associated protein 2G4 (PA2G...
Apoptotic extracellular vesicles: unveiling mechanisms, diverse functions, and biomedical implications [0.03%]
凋亡小体外泌体：揭示机制、多样功能和生物医学意义
Xuan Li,Keyu Wang,Caining Wen et al.
Xuan Li et al.
Apoptotic extracellular vesicles (ApoEVs), once dismissed as inert "cellular debris," are now recognized as dynamic membrane-bound vesicles actively released during apoptosis, functioning as essential signaling platforms that coordinate tis...
Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic Frontiers [0.03%]
神经退行性疾病中的非经典细胞死亡：新兴机制和治疗前景
Nilufer Ercin,Nail Besli,Merve Beker et al.
Nilufer Ercin et al.
Neurodegenerative diseases, specifically Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS) are defined by progressively increased neuronal loss that lacks curative therapi...
Oncogenic and immunological roles of LAMP5 across cancers and its potential utility in bladder cancer [0.03%]
LAMP5在肿瘤学和免疫学中的作用及其在膀胱癌中的潜在应用价值研究进展
Zhenni Lin,Kun Zhao,Sijia Wang et al.
Zhenni Lin et al.
Lysosomal associated membrane protein family member 5 (LAMP5), a recently identified member of the LAMP family, has been associated with poor prognosis in multiple cancer types; however, its precise oncogenic mechanisms remain unclear. This...
Chronic and non-canonical cGAS-STING activation: implications for health, disease, cancer, and emerging therapeutic opportunities [0.03%]
慢性及非经典cGAS-STING激活的效应及其对健康、疾病、癌症和新兴治疗机会的影响
Hitesh Vasiyani
Hitesh Vasiyani
Immunotherapy has drawn attention in the current era; CAR T cells and STING agonists are emerging as novel approaches for cancer treatment. Advances in STING agonist development are ongoing, and many remain in the preclinical stage. At the ...
LncRNA AC098613.1 promotes acute myeloid leukemia cell differentiation through CDC5L/ADAP1/NRD1 axis [0.03%]
长链非编码RNA AC098613.1通过CDC5L/ADAP1/NRD1轴促进急性髓系白血病细胞分化
Qingling Jiang,Xiaoting Wang,Hang Yao et al.
Qingling Jiang et al.
Recently evidence has suggested that long non-coding RNAs (lncRNAs) play a pivotal role in the prognosis and treatment of leukemia. However, studies on their use in differentiation therapy of acute myeloid leukemia (AML) remain scarce. In t...
Berberine inhibits ISG15 and pyroptosis to attenuate diabetic kidney disease inflammation and fibrosis [0.03%]
巴马汀通过抑制ISG15和细胞焦亡减轻糖尿病肾病炎症及纤维化
Lingzhi Huang,Qinqin Chen,Xiaoxiao Liu et al.
Lingzhi Huang et al.
Diabetic kidney disease (DKD) is a microvascular complication of diabetes accompanied by inflammation and tubular fibrosis. Berberine (BBR), a plant alkaloid and traditional Chinese medicine, has been shown to have beneficial effects on DKD...