Boris Zhivotovsky,Katharina D&#x;Herde,Zahra Zakeri et al.
Boris Zhivotovsky et al.
Mitochondria-associated programmed cell death in pancreatic β cell of T2DM [0.03%]
2型糖尿病胰岛β细胞线粒体相关程序性细胞死亡研究进展
Ying Zhang,Chuchu Wang,Puhua Zhang et al.
Ying Zhang et al.
Mitochondria, as essential organelles that integrate energy metabolism and intracellular signaling, have recently gained increasing attention in the study of pancreatic β-cell dysfunction in type 2 diabetes mellitus (T2DM). Programmed deat...
Caspase-1 in cancer and inflammatory diseases: a potential therapeutic target [0.03%]
Caspase-1在癌症和炎症性疾病中的作用及作为治疗靶点的潜力
Xuan Sun,Wen-Bin Ou
Xuan Sun
Caspase-1, a cysteinyl aspartate-specific protease central to inflammasome activation, acts as a master regulator of multiple programmed cell death (PCD) pathways including pyroptosis, apoptosis, necroptosis, ferroptosis, and PANoptosis. It...
COL8A1-positive cancer-associated fibroblasts are drivers of 5-fluorouracil resistance in colorectal cancer [0.03%]
COL8A1阳性癌相关成纤维细胞是结直肠癌5-氟尿嘧啶耐药的驱动因素
Muzi Ding,Yue Li,Zixuan Liu et al.
Muzi Ding et al.
Acquired resistance to 5-fluorouracil (5-FU) curtails the survival benefit of chemotherapy in colorectal cancer (CRC). We asked whether a discrete subset of cancer-associated fibroblasts (CAFs) drives this phenotype. Multi-omic profiling of...
Disruption of sphingolipid metabolism triggers lung vascular inflammation and aging-like changes under hypoxia through VDAC1-mediated mitochondrial DNA release [0.03%]
缺氧时鞘脂代谢紊乱通过电压依赖性(anion)通道蛋白1介导的线粒体DNA释放触发肺血管炎症和老化样变化
Jin Xu,YiLing Ge,Bin Zhang et al.
Jin Xu et al.
The lung, a key organ for oxygen exchange, is particularly susceptible to high-altitude hypoxic stress. Hypoxia induces vascular impairment, which is characterized by vascular inflammatory responses and aging-like changes. Lipid metabolism ...
cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication [0.03%]
环境污染物致病的cGAS-STING信号通路机制及缓解药物研究
Menglan Yan,Shiqi Li,Yuan Wei et al.
Menglan Yan et al.
Environmental pollutants have long been a major threat to human health, and long-term or high-concentration exposure can trigger acute or chronic diseases. These hazards often mediate tissue dysfunction and drive disease progression by indu...
Mitochondrial function meets oncology: the multifaceted role of TFAM across cancer types [0.03%]
线粒体功能与肿瘤学：转录因子 TFAM 在各种癌症中的作用
Jie Wang,Ruicheng Wu,Fanglin Shao et al.
Jie Wang et al.
Mitochondrial transcription factor A (TFAM) is indispensable for mitochondrial DNA (mtDNA) maintenance and transcription, governing cellular bioenergetics. Despite its known physiological importance, TFAM plays a complex and often paradoxic...
SPAG5 promotes ferroptosis and enhances chemotherapy efficacy in locally advanced colorectal cancer via upregulating intracellular ROS levels [0.03%]
SPAG5通过上调细胞内ROS水平促进铁死亡并增强局部晚期结直肠癌的化疗疗效
Ruiqi Gu,Hongsheng Fang,Yunpu Xu et al.
Ruiqi Gu et al.
Colorectal cancer (CRC) has a high incidence and mortality rate worldwide, with chemotherapy being a cornerstone of treatment for locally advanced CRC patients (LACRC). Despite the relatively high efficacy of chemotherapy regimens like FOLF...
Crosstalk between protein lipidation and ubiquitination in tumor biology [0.03%]
蛋白质脂基化与泛素化在肿瘤生物学中的互作关系研究
Jiahong Liao,Qian Huang,Zhuoyuan Yang et al.
Jiahong Liao et al.
Protein lipidation and ubiquitination are two fundamental post-translational modifications that orchestrate protein localization, stability, and function. Beyond their independent roles, emerging evidence reveals a complex crosstalk between...
M2pep-modified liposomal nanoparticles delivering siITGB4 induce apoptosis and inhibit NSCLC metastasis via macrophage reprogramming [0.03%]
经M2pep修饰的载有siITGB4的脂质体纳米颗粒通过重塑巨噬细胞诱导NSCLC细胞凋亡并抑制其转移
Xiaofeng Huang,Fei Shen,Dengshu Wang et al.
Xiaofeng Huang et al.
Non-small cell lung cancer (NSCLC) metastasis, driven by tumor-associated macrophages (TAMs), remains a significant challenge due to poor prognosis and limited therapeutic options. This study developed DSPE-PEG-M2pep-modified liposomal nano...