Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME) [0.03%]
HIF-1α与肿瘤免疫微环境(TIME)中各种细胞死亡途径的相互作用
Mahsa Manafi Varkiani,Ferdos Faghihkhorasani,Mona Moosavi et al.
Mahsa Manafi Varkiani et al.
Background: Hypoxia-inducible factor-1 alpha (HIF-1α) is a key mediator of tumor adaptation to hypoxic stress. In addition to its canonical roles in angiogenesis and metabolic reprogramming, HIF-1α modulates multiple re...
The histone demethylase KDM4A promotes esophageal cancer progression by epigenetically activating LRG1-mediated TGF-β signaling [0.03%]
组蛋白去甲基化酶KDM4A通过表观遗传活化LRG1介导的TGF-β信号促进食管癌进展
Yueting Han,Huiya Wang,Yaoyang Guo et al.
Yueting Han et al.
Esophageal squamous cell carcinoma (ESCC) remains a lethal malignancy with a poor 5-year survival rate of approximately 20%, necessitating the identification of novel therapeutic targets. Here, we show that KDM4A is significantly upregulate...
Looking at the fraction with Annexin V⁺ and propidium iodide⁺: insights into cell death types from preclinical studies in solid and haematological cancers [0.03%]
Annexin V和碘化丙啶联合染色法的观察：来自实体瘤和血液系统癌症药效学研究的细胞死亡类型分析
Siti Nazihahasma Hassan,Farizan Ahmad
Siti Nazihahasma Hassan
Fluorescein isothiocyanate-conjugated Annexin V in combination with propidium iodide (PI) labelling is a widely used flow cytometric assay for quantifying apoptotic and necrotic cells in anticancer studies. However, increasing evidence sugg...
A novel triaptosis-related prognostic signature to assess the clinical value in HER2-low breast cancer: evidence from clinical cohorts and experimental validation [0.03%]
一种新的与三联症相关的预后标志物，用于评估HER2低表达乳腺癌的临床价值：来自临床队列和实验验证的证据
Jinsong Liu,Xiao Guan,Min Dou et al.
Jinsong Liu et al.
Background: HER2-low breast cancer (BC) represents a biologically distinct subtype with limited predictive biomarkers. Triaptosis is a recently described form of oxidative stress-associated endosomal dysfunction mediated ...
Traffic and functional polarization of macrophages in the areas of programmed interdigital cell death in the embryonic chick [0.03%]
鸡胚手指间程序性细胞死亡区域巨噬细胞的交通和功能极化现象研究
G Moran,C Duarte-Olivenza,J M Hurle et al.
G Moran et al.
In this study, we show that during digit development, the embryonic limb contains an abundant and widespread population of "resident macrophages" that precede the onset of interdigital cell death responsible for the separation of digit prim...
Semaglutide attenuates diabetic vascular calcification by enhancing autophagy and lysosomal function via targeting CPNE1 [0.03%]
索马鲁肽通过靶向CPNE1增强自噬和溶酶体功能以缓解糖尿病血管钙化
Shengjue Xiao,Wei Li,Naifeng Liu
Shengjue Xiao
Patients with diabetes exhibit an increased susceptibility to vascular calcification, which is associated with significantly elevated risks of mortality and disability. As a new Glucagon-like peptide-1 receptor agonist, Semaglutide is prima...
Metrnl in health and disease: tissue-specific actions and signaling networks [0.03%]
母体营养素在健康和疾病中的作用及信号网络
Ran Zhao,Yue Qi,Pan Li et al.
Ran Zhao et al.
Emerging as a novel secreted protein, Meteorin-like (Metrnl) exhibits substantial sequence homology with Meteorin (Metrn). Although Metrnl was initially identified in the context of adipose tissue and metabolic regulation, accumulating evid...
Spatially defined danger zone shapes gastric cancer progression through CCDC80+ fibroblast-induced CD8+ T cell dysfunction [0.03%]
空间界定的危险区域通过CCDC80+成纤维细胞诱导CD8+T细胞功能障碍促进胃癌进展
Shaocong Mo,Yulin Wang,Rong Xiong et al.
Shaocong Mo et al.
Gastric cancer (GC) shows marked heterogeneity driven by the tumor microenvironment, leading to therapeutic resistance and poor prognosis. Using spatial transcriptomics of invasive murine tumors and human GC samples, we identified a distinc...
Superenhancer-driven SMC4 promotes myeloma growth by epigenetically enhancing IFI16-dependent STING signaling [0.03%]
超增强子驱动的SMC4通过表观遗传学增强IFI16依赖性STING信号促进多发性骨髓瘤生长
Jiayun Guan,Xuanyi Lin,Zhenfeng Dai et al.
Jiayun Guan et al.
Multiple myeloma (MM) is a complex hematological malignancy characterized by the uncontrolled proliferation of plasma cells in the bone marrow. Emerging evidence suggests that the aberrant activation of specific gene regulatory elements kno...
Adenylate kinase 4 promotes radioresistance by suppressing radiation-induced ferroptosis through metabolic regulation in glioblastoma [0.03%]
腺苷酸激酶4通过代谢调节抑制放射诱导的铁死亡从而促进胶质母细胞瘤的放射抵抗性
Byeongsoo Kim,Hyunkoo Kang,Junhyeong Park et al.
Byeongsoo Kim et al.
Primary solid tumors often exhibit accelerated glucose metabolism yet generate limited ATP due to reduced flux through the tricarboxylic acid (TCA) cycle. However, how these distinct metabolic alterations contribute to therapeutic resistanc...