The circTIMP2/miR-106a/TIMP2 tumor-suppressive axis versus tumor-derived exosomal counteraction in gastric cancer [0.03%]
胃癌中circTIMP2/miR-106a/TIMP2抑癌轴与肿瘤来源外泌体的拮抗作用
Meng Zhu,Xinwei Dong,Ning Zhang et al.
Meng Zhu et al.
Gastric cancer is a multifactorial disease and remains one of the leading causes of cancer-related deaths worldwide. CircRNAs have emerged as critical regulators in various cancers, while exosomes play essential roles in shaping the tumor m...
Unveiling the multifaceted roles of BCL3: biological functions and disease implications [0.03%]
揭示BCL3的多面作用：生物学功能和疾病影响
Xiaoqing Guo,Ruxing Guo,Wei Wang et al.
Xiaoqing Guo et al.
BCL3 (B-cell CLL/lymphoma 3), initially identified in the t(14;19) chromosomal translocation in B-cell malignancies, is an atypical member of the inhibitor of NF-κB (IκB) protein family. Unlike classical IκB proteins, BCL3 predominantly ...
Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis [0.03%]
HERC2-FTL轴干扰铁稳态导致软骨细胞丢失并加重骨关节炎
Yuting Zhong,Juan Duan,Zeyu Chen et al.
Yuting Zhong et al.
Osteoarthritis (OA) is a common degenerative joint disease marked by cartilage degradation, inflammation, and subchondral bone remodeling. Ferroptosis, an iron-dependent form of programmed cell death, has recently emerged as a key contribut...
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor [0.03%]
Piezo1通道介导的铁死亡及其抑制剂的治疗潜力
Kai Nan,Lei Zhang,Yan Zhao et al.
Kai Nan et al.
Piezo1 is a mechanically activated, non-selective cation channel characterized by its exquisite sensitivity to membrane tension and high permeability to calcium(Ca2+), enabling the conversion of mechanical stimuli into intracellular signali...
Adverse outcome pathway analysis identifies DRP1-driven mitochondrial dysfunction as a central event in silver nanoparticle-induced hepatocyte ferroptosis [0.03%]
不良结局途径分析确定了银纳米颗粒诱导的线粒体功能障碍驱动肝细胞铁死亡的核心事件
Jiangyan Li,Jiaqi Lan,Zhiwen Liu et al.
Jiangyan Li et al.
Background: Silver nanoparticles (AgNPs) are increasingly employed across diverse applications, raising concerns regarding their potential biosafety risks. The liver plays a pivotal role as a target organ upon exposure to...
Decoding microglial metabolic cell death and PANoptosis hub genes in subacute phase of traumatic brain injury: a multi-omics and experimental validation study [0.03%]
创伤性脑损伤亚急性期小胶质细胞代谢性细胞死亡和PANoptosis中心基因的解码：一项多组学和实验验证研究
Zhe Wu,Bao-Ya Yang,Jin-Qing Lai et al.
Zhe Wu et al.
Nicotine suppresses ferroptosis in colon cancer cells via HMOX1/NF-κB pathway to reduce oxaliplatin sensitivity [0.03%]
尼古丁通过HMOX1/NF-κB信号通路抑制结肠癌细胞铁死亡从而降低奥沙利铂的治疗敏感性
Fangyin Xu,Lian Xie,Zhendong Zhang et al.
Fangyin Xu et al.
Background As the primary active component in tobacco, nicotine is significantly associated with chemotherapy resistance in colon cancer. However, the molecular mechanisms through which nicotine contributes to chemotherapy resistance in col...
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis [0.03%]
低密度脂蛋白受体相关蛋白2通过乳酸/MCT1/AMPK/mTOR轴加重脓毒症诱导的急性肺损伤介导黏蛋白1抑制引起的内质网应激-自噬诱导的铁死亡
Si-Xia Chen,Xing Qi,Xiang-Tao Zheng et al.
Si-Xia Chen et al.
Severe sepsis leads to damage of multiple organs, among which the lung is the most commonly damaged organ, yet its underlying mechanisms and therapeutic strategies are incompletely understood. Western blot and Immunohistochemistry analyses ...
BACH2 ameliorates cell apoptosis and autophagy as a molecular switch of BCL-2/Beclin-1 complex in myocardial infarction [0.03%]
BACH2通过充当BCL-2/Beclin-1复合物的分子开关来改善心肌梗死中的细胞凋亡和自噬
Xiaolin Wang,Hongyuan Zhang,Xi Liu et al.
Xiaolin Wang et al.
Myocardial infarction is a major cause of death and disability worldwide. Programmed cell death (PCD) of cardiomyocytes is a predominant pathological manifestation. However, the specific PCD subtypes involved in myocardial infarction remain...
The role of KPNA3 in multiple myeloma: implications for targeting nuclear import [0.03%]
KPNA3在多发性骨髓瘤中的作用：靶向核输入的启示
Hongmei Luo,Ziyue Mi,Jingcao Huang et al.
Hongmei Luo et al.
Multiple myeloma (MM) is an incurable tumor of malignant plasma cells. Importin α4, also known as KPNA3, is a component of the importin α/β system, which contributes to the cytosol-to-nucleus trafficking of cellular substances. In this s...