MUDENG, a component of adaptor complex 5, mediates TRAIL- and TMZ-triggered apoptosis in glioblastoma (GBM) via multiple pathways [0.03%]
MUDENG通过多种途径介导适应蛋白复合物5触发的胶质母细胞瘤中的TRAIL和TMZ诱导的凋亡反应
Juhyun Shin,Yoon-Mi Lee,SooHyun Jung et al.
Juhyun Shin et al.
Glioblastoma (GBM) is one of the most aggressive and treatment-refractory brain tumors. Temozolomide (TMZ) remains the standard chemotherapeutic agent but is frequently compromised by DNA-repair mechanisms, whereas tumor necrosis factor (TN...
DKK1 expression associates with tertiary lymphoid structure maturity in non-small cell lung cancer [0.03%]
非小细胞肺癌中DKK1表达与三级淋巴组织成熟相关的研究
Lin Ma,Linlin Yang,Junxu Wen et al.
Lin Ma et al.
Tertiary lymphoid structures (TLS) are organized lymphoid aggregates that form outside lymph nodes within the tumor microenvironment. They are linked to better prognosis and stronger antitumor immune responses. However, the key molecular fa...
Assessment of female fertility and oocyte quality in mice after exposure to polystyrene microplastics and polybrominated diphenyl ethers, alone and in combination [0.03%]
聚苯乙烯微塑料和多溴二苯醚及其联合作用对小鼠雌性生育力和卵子质量的评估
Wenwen Hou,Zaishan Yang,Xiaoyan Zhou et al.
Wenwen Hou et al.
With the extensive use of plastics and brominated flame retardants, polystyrene microplastics (Ps-MPs) and polybrominated diphenyl ethers (PBDEs) frequently co-occur in the environment, raising growing concerns about their combined reproduc...
Qianqian Yang,Xinxin Ren,Ruonan Jia et al.
Qianqian Yang et al.
Epidemiological investigations have indicated that Alzheimer's disease (AD) has emerged as a predominant health challenge among older adults, with its mortality rate rising sharply each year. Nevertheless, measures capable of delaying or ha...
HSP90 inhibition potentiates oxidant-based antimelanoma action of novel thioquercetin derivatives by compromising AhR/CYP1A1 pathway [0.03%]
HSP90抑制通过破坏AhR/CYP1A1途径增强新型硫化槲皮素衍生物的抗黑色素瘤抗氧化作用
Wojciech Witkowski,Julia Słaby,Maciej Wnuk et al.
Wojciech Witkowski et al.
Quercetin, a plant-derived dietary flavonoid, has multifunctional biological activities, including anticancer action; however, its applications may be restricted due to limited bioavailability. Thus, novel synthetic quercetin derivatives (Q...
Targeting mitochondrial apoptosis in septic lung injury: protective potential of omega-3 fatty acids [0.03%]
ω-3脂肪酸通过靶向线粒体凋亡保护内毒素致肺损伤的作用研究
Ersin Çelik,Pınar Karabacak,Mustafa Soner Özcan et al.
Ersin Çelik et al.
Acute lung injury secondary to sepsis remains a major problem in critical patients. Lipopolysaccharide (LPS)-induced lung injury is characterized by inflammatory infiltration, oxidative stress, and extensive apoptosis, particularly via the ...
Role of POLE2/GINS1-mediated AKT/mTOR pathway in RCC autophagy, proliferation, and metastasis: evidences from bioinformatic, clinical, and experimental data [0.03%]
POLE2/GINS1介导的AKT/mTOR信号通路在肾细胞癌自噬、增殖和转移中的作用：来自生物信息学、临床和实验数据的证据
Yajuan Su,Wentao Wang,Xingyuan Wang et al.
Yajuan Su et al.
POLE2 exhibits oncogenic properties. This study aimed to clarify its effects and underlying mechanisms in renal cell carcinoma (RCC). Using bioinformatics analyses, we predicted the relationship between POLE2 and autophagy, epithelial-mesen...
Transcriptome sequencing (RNA-Seq) reveals non-coding pseudogene CDC27P9 role in cervical cancer [0.03%]
宫颈癌中非编码假基因CDC27P9的作用的转录组测序(RNA-Seq)分析研究
Fenwick Antony Edwin Rodrigues,Deena Krishnan,Hussein Hameed Abbas et al.
Fenwick Antony Edwin Rodrigues et al.
Non-Coding regions contains genomic remnants called as Pseudogenes. For a long time, pseudogenes have been regarded as non-functional. This study investigates the previously unstudied Pseudogene CDC27P9 role in cervical cancer. Whole RNA-tr...
Targeted delivery of RGD-JEG-3-EVs for placental vascular regeneration in preeclampsia: from molecular mechanism toward therapy [0.03%]
针对子痫前期胎盘血管再生的RGD-JEG-3-EVs靶向投递：从分子机制到治疗
Qi Wang,Quanbo Liu,Xi Yuan
Qi Wang
Insulin-like growth factor binding protein-3 serves as a biomarker for resistance to enzalutamide in prostate cancer [0.03%]
胰岛素样生长因子结合蛋白-3作为前列腺癌患者恩杂卢胺耐药生物标志物的研究
Ze Gao,Bingzheng An,Shuo Chen et al.
Ze Gao et al.
Enzalutamide resistance (EnzR) is a major challenge in the current treatment of castration-resistant prostate cancer, as tumors frequently progress to drug resistance after an initially effective treatment. Therefore, there is an urgent nee...