Programmed cell death in lung cancer: mechanisms, immune responses, and therapeutics [0.03%]
肺癌的程序性细胞死亡：机制、免疫反应与治疗策略
Yang Liu,Qingxin Chen,Jiayu Xu et al.
Yang Liu et al.
Lung cancer remains the leading cause of cancer-related mortality worldwide, with an estimated 2.2 million new cases and 1.8 million deaths in 2020. Despite improvements achieved through cytotoxic chemotherapy and immune checkpoint blockade...
The GATA3-RFPL3-ASK1 axis suppresses breast cancer growth and lung metastasis [0.03%]
GATA3-RFPL3-ASK1信号轴抑制乳腺癌生长和肺转移
Kang Li,Chang Liu,Jun-Hui Yin et al.
Kang Li et al.
Despite the great improvements made in its clinical management during the past decades, breast cancer remains a challenge with considerably high morbidity and mortality. Further efforts to explore new biomarkers with promising clinical pote...
Relationship between different modes of death and premature ovarian insufficiency: a literature review [0.03%]
死亡方式与卵巢早衰关系的研究进展：一篇综述
Huihui Li,Ruotong Ju,Puhua Zhang et al.
Huihui Li et al.
Early-onset ovarian insufficiency (POI) is a heterogeneous disorder characterized by complex etiology and the involvement of diverse programmed cell death modalities. This review aims to systematically elucidate the molecular mechanisms und...
Dynamic collaboration between mitochondria and organelles: mechanisms, functions, and disease implications [0.03%]
线粒体与其他细胞器的动态协作：机制、功能及其疾病意义
Bin Shao,Yifeng Zeng,Jian Ju
Bin Shao
In recent years, numerous studies have revealed that dysregulation of mitochondria-organelle interactions is a common feature underlying various pathological processes and pathogen infections. For instance, in Alzheimer's disease (AD), dysf...
Kaempferol protects melanocytes from ferroptosis by modulating the NF-κB/PTGS2 signaling axis in vitiligo [0.03%]
芸香素通过调节NF-κB/PTGS2信号轴保护白癜风中黑素细胞免受铁死亡侵害
Xuqing Xu,Zixian Lei,Wen Hu et al.
Xuqing Xu et al.
Oxidative stress-induced ferroptosis is increasingly recognized as an important contributor to melanocyte destruction in vitiligo; however, the specific upstream signaling networks linking inflammatory signaling to ferroptosis susceptibilit...
Pyroptosis as a double-edged sword in colorectal cancer: Molecular mechanisms and therapeutic opportunities [0.03%]
焦亡在结直肠癌中的双刃剑作用：分子机制和治疗机会
Han-Xi Zhang,Wen-Jing Xu,Yi-Xin Jiang et al.
Han-Xi Zhang et al.
Colorectal cancer (CRC) is the third most prevalent malignancy globally, with its incidence and mortality rates exhibiting a consistent upward trend. It is commonly diagnosed at an advanced stage, constraining the available therapeutic stra...
Targeting VDAC1 to protect against mitochondria-linked cell death pathways: apoptosis, pyroptosis, ferroptosis, and associated diseases [0.03%]
靶向线粒体外膜蛋白VDAC1以抑制多种细胞死亡程序及相关疾病发生发展的新策略
A Shteinfer-Kuzmine,A Karunanithi Nivedita,M Santhanam et al.
A Shteinfer-Kuzmine et al.
The pathways of programmed cell death (PCD), including apoptosis, pyroptosis, and ferroptosis, are interconnected. They can be activated simultaneously within tissues or cell lines and are often associated with various diseases. Thus, ident...
SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease [0.03%]
SIRT1调节的线粒体自噬可缓解糖尿病肾脏疾病中的脂毒性诱导的铁死亡
Yingchun Jian,Yongqin Zeng,Zhengdi Wang et al.
Yingchun Jian et al.
Diabetic kidney disease (DKD) is characterized by renal lipid deposition, andlipotoxicity-induced ferroptosis plays a pivotal role in its progression. This study aimed to elucidate the regulatory mechanism of silent information regulator 1 ...
Helicobacter pylori activates the TRAF1/OASL/ZBP1-PANoptosome pathway to induce PANoptosis in the gastric mucosa [0.03%]
幽门螺杆菌激活胃黏膜中的TRAF1/OASL/ZBP1-PANoptosome途径诱导PANoptosis反应
Minglin Zhang,Xueer Yang,Jie Xie et al.
Minglin Zhang et al.
Helicobacter pylori (H. pylori) has been identified as a pathogenic factor in gastric cancer (GC). Building on our previous findings that VacA upregulates TRAF1, which in turn transcriptionally activates OASL, we explored the role of this T...
NUFIP1-engineered exosomes modulate propofol-induced neurotoxicity in neonatal rats via the ERS apoptotic pathway [0.03%]
内皮素受体介导的新型纳米工程外泌体通过调节内质网应激凋亡途径减轻异丙酚所致新生大鼠神经毒性作用
Pengyue Zhao,Yang Yan,Bin Lan et al.
Pengyue Zhao et al.
Early-life exposure to general anesthetics, particularly propofol, elevates the risk of neurodevelopmental impairment and cognitive sequelae in pediatric populations, representing a pivotal concern in translational neuroanesthesiology. Alth...