Mycobacterium tuberculosis PE_PGRS18 enhances the intracellular survival of M. smegmatis via altering host macrophage cytokine profiling and attenuating the cell apoptosis [0.03%]
结核分枝杆菌PE_PGRS18通过改变宿主巨噬细胞因子谱型及抑制细胞凋亡增强烟曲霉菌的胞内生存能力
Wenmin Yang,Wanyan Deng,Jie Zeng et al.
Wenmin Yang et al.
Mycobacterium tuberculosis PE/PPE family proteins, named after the presence of conserved PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains at N-terminal, are prevalent in M. tuberculosis genome. The function of most PE/PPE family proteins remains ...
Two coffins and a funeral: early or late caspase activation determines two types of apoptosis induced by DNA damaging agents [0.03%]
两种凋亡途径：DNA损伤诱导的细胞凋亡类型由早发或迟发的Caspase激活所决定
Manuel Oropesa-Ávila,Patricia de la Cruz-Ojeda,Jesús Porcuna et al.
Manuel Oropesa-Ávila et al.
Cell cytoskeleton makes profound changes during apoptosis including the organization of an Apoptotic Microtubule Network (AMN). AMN forms a cortical structure which plays an important role in preserving plasma membrane integrity during apop...
Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer [0.03%]
cardamonin通过调节信号转导及转录激活子3通路抑制前列腺癌的增殖、浸润并引起凋亡
Jingwen Zhang,Sakshi Sikka,Kodappully S Siveen et al.
Jingwen Zhang et al.
The pleiotropic transcription factor, signal transducer and activator of transcription 3 (STAT3) is often aberrantly activated in a wide variety of cancers and plays a pivotal role in tumor initiation, promotion and progression. Targeting d...
The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells [0.03%]
糖皮质激素受体与Bcl-2家族成员合作调节发育性T细胞线粒体凋亡途径
Lilla Prenek,Ferenc Boldizsár,Réka Kugyelka et al.
Lilla Prenek et al.
Glucocorticoids (GC) are important in the regulation of selection and apoptosis of CD4+CD8+ double-positive (DP) thymocytes. The pronounced GC-sensitivity of DP thymocytes, observed earlier, might be due to the combination of classical (gen...
A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade [0.03%]
一种新型的4,6-取代-1,2,4-三氮唑并-1,3,4-噻二唑衍生物通过消除NF-κB活化级联抑制肿瘤细胞侵袭并增强TNFα凋亡效应
Raghu Ningegowda,Nanjunda Swamy Shivananju,Peramiyan Rajendran et al.
Raghu Ningegowda et al.
Condensed-bicyclic 4,6-substituted1,2,4-triazolo-1,3,4-thiadiazole derivatives (CBTT) have been shown to possess a wide spectrum of pharmacological activities. In this study, several novel CBTT derivatives were synthesized and investigated ...
Gaspar Banfalvi
Gaspar Banfalvi
Dying cells subjected to apoptotic programs are engulfed by neighboring cells or by professional phagocytes, without inflammation or immunological reactions in the tissue where apoptosis takes place. Apoptotic cells release danger-associate...
HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer [0.03%]
HSP90是gemcitabine和5-氟尿嘧啶耐药性胰腺癌的一个有希望的靶点
Tarik Ghadban,Judith L Dibbern,Matthias Reeh et al.
Tarik Ghadban et al.
Chemotherapy (CT) options in pancreatic cancer (PC) are limited to gemcitabine and 5-fluorouracil (5-FU). Several identified molecular targets in PC represent client proteins of HSP90. HSP90 is a promising target since it interferes with ma...
DMFC (3,5-dimethyl-7H-furo[3,2-g]chromen-7-one) regulates Bim to trigger Bax and Bak activation to suppress drug-resistant human hepatoma [0.03%]
3,5-二甲基-7H-呋喃并[3,2-G]异喹啉-7-酮（DMFC）通过调节BIM启动BAX和BAK活化以抑制药物抵抗性人类肝癌细胞
Jun Xiang,Zhe Wang,Qianqian Liu et al.
Jun Xiang et al.
3,5-Dimethyl-7H-furo[3,2-g]chromen-7-one (DMFC) is a coumarin derivative with anti-cancer activity against human hepatoma cells, but the mechanisms underlying DMFC function in cancer suppression is unknown. In this study, we aimed at elucid...
Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling [0.03%]
血红素氧合酶-1通过抑制Cdc42/MLK3/MKK7/JNK3信号通路保护脊髓神经元免受过氧化氢诱导的细胞凋亡损伤
Siyuan Wang,Tao Zhang,Zhen Yang et al.
Siyuan Wang et al.
The mechanisms by which oxidative stress induces spinal cord neuron death has not been completely understood. Investigation on the molecular signal pathways involved in oxidative stress-mediated neuronal death is important for development o...
Advanced oxidation protein products induce chondrocyte death through a redox-dependent, poly (ADP-ribose) polymerase-1-mediated pathway [0.03%]
先进氧化蛋白产物通过红氧依赖的多(腺苷二磷酸-核糖)聚合酶-1介导的途径诱导软骨细胞死亡
Wenbin Ye,Zhaoming Zhong,Siyuan Zhu et al.
Wenbin Ye et al.
This study aimed to investigate the effect of AOPPs on apoptosis in human chondrocytes. Chondrocytes were treated with AOPPs. Cell death, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, reactive oxygen species (ROS) ge...