Fen Liu,Jiahai H Xiao,Yujuan J Song et al.
Fen Liu et al.
Iron-catalyzed lipid peroxidation, a hallmark of the regulated cell death (RCD) known as ferroptosis, has gained prominence in cancer biology, and its application in anticancer treatments is gaining attention. Triggering ferroptosis may cur...
The role and mechanisms of vitamin A in suppressing hepatic stellate cell activation [0.03%]
维生素A通过抑制肝星状细胞活化发挥抗纤维化作用及机制研究进展
Wen Jia,Nannan Zhang,Daijiang Liu et al.
Wen Jia et al.
Multi-layered integrated shielding: engineering ferroptosis-resistant mesenchymal stem cells for precision therapy of intervertebral disc degeneration [0.03%]
多层集成屏蔽：工程化铁死亡抵抗性间充质干细胞精准治疗椎间盘退变
Yuzhu Xu,Zhanyang Qian,Mingliang Ji et al.
Yuzhu Xu et al.
Introduction: Intervertebral disc degeneration (IVDD) is a predominant cause of low back pain, and mesenchymal stem cell (MSC) transplantation represents a promising therapeutic strategy. However, its efficacy is severely...
Propofol attenuates angiogenesis by activating endoplasmic reticulum stress to suppress TFAP2C-driven VEGFA transcription [0.03%]
异丙酚通过激活内质网应激抑制TFAP2C驱动的VEGFA转录从而发挥抗血管生成作用
Fan Yang,Yi Liu,Hui Li et al.
Fan Yang et al.
During anesthesia, significant hemodynamic changes often alter the vascular microenvironment and affecting endothelial cell behavior. Propofol, a commonly used intravenous anesthetic, has been widely studied for its role in tumor angiogenes...
CSN5 overexpression promotes the integral progression of cervical cancer by enhancing ENO3-mediated glycolysis [0.03%]
CSN5过表达通过增强ENO3介导的糖酵解促进宫颈癌的整体进展
Zhu Cao,Shizhou Yang,Jian Zou et al.
Zhu Cao et al.
Cervical cancer (CC) remains a significant global health challenge. A deeper understanding of the molecular mechanisms driving CC progression is crucial for developing improved therapeutic strategies. CSN5 is vital in cell functions and can...
Activation of RIPK3 drives PANoptosis in human cells and inflammatory apoptosis in canine cells dependent on RIPK1, FADD and caspases [0.03%]
RIPK3激活驱动人类细胞PANoptosis和依赖于RIPK1、FADD和半胱天冬酶的犬类细胞炎性凋亡
Sarah M Worfolk,Noah J Phippen,Shayla G Verburg et al.
Sarah M Worfolk et al.
Programmed cell death in animal species of the order Carnivora is suspected to be unique due to the potential defects in activating the lytic cell death pathways, necroptosis and pyroptosis. In a wide range of species of the order Carnivora...
Advances in the research of gasdermin-dependent pyroptosis mechanisms and therapeutic targets in inflammatory diseases [0.03%]
Gasdermin依赖性炎性细胞焦亡在炎症性疾病中的机制研究进展及治疗靶标探讨
Chuanyu Shen,Yiming Zhang,Chuqiao Wei et al.
Chuanyu Shen et al.
Inflammation, especially invasive bacterial inflammation, has always been a hot topic in medical research. With the emergence of superbugs and highly virulent viruses, current treatment methods are gradually revealing areas of deficiency. A...
Mitochondria-ER crosstalk via MAMS: Bridging cellular homeostasis and cancer progression [0.03%]
线粒体-内质网接触点MAMS：连接细胞稳态和肿瘤进展
Rohan Roy,Arghya Adhikary,Rudranil De et al.
Rohan Roy et al.
Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic contact points between the endoplasmic reticulum (ER) and mitochondria, governing essential cellular processes such as calcium (Ca²⁺) signaling, lipid metabolism, ...
SFG enhances apoptosis of hepatocellular carcinoma by inhibiting tunneling nanotubes-mediated mitochondrial transport in the tumor microenvironment [0.03%]
SFG通过抑制肿瘤微环境中隧道纳米管介导的线粒体运输增强肝癌细胞凋亡
Shasha Kong,Yuling Liu,Ruying Tang et al.
Shasha Kong et al.
Hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, is characterized by a rising incidence and an alarmingly low rate of early diagnosis, presenting a significant global public health challenge. Th...
Progenitor CD8+ T cells and hyper-Treg crosstalk: a driver of immune checkpoint inhibitor resistance in esophageal squamous cell carcinoma [0.03%]
前体CD8+t细胞与高反应性调节性t细胞互作：食管鳞癌免疫检查点抑制剂耐药的驱动因素
Suning Huang,Jingwei Yan,Wenqi Liu et al.
Suning Huang et al.
Despite the crucial role of antigen presentation in immune checkpoint inhibitor (ICI) efficacy, its contribution and the mechanism in esophageal squamous cell carcinoma (ESCC) remain unclear, representing a key knowledge gap in overcoming i...