Autophagy-lysosomal dependency defines a vulnerable physiological state in drug-tolerant persister cells of triple-negative breast cancer [0.03%]
Essha Chatterjee,Biswajit Dey,Anamika Sharma et al.
Essha Chatterjee et al.
Triple-negative breast cancer (TNBC), a subtype of aggressive breast cancer, has limited treatment options. Recurrent disease caused by drug-tolerant persister cells (DTPs) that evade chemotherapeutic agents (e.g., doxorubicin hydrochloride...
Gut microbiota-tryptophan-serotonin axis drives anxiety-like behavior via NLRP3-mediated neuronal pyroptosis in the medial prefrontal cortex [0.03%]
Guiqiang Zhou,Xing Wang,Tongzhou Qin et al.
Guiqiang Zhou et al.
The gut-brain axis plays a critical role in anxiety disorders, yet the underlying mechanisms remain incompletely understood. Using a mouse model of radiofrequency radiation (RFR)-induced anxiety-like behaviors, we employed gut microbiota in...
Hua Fu,Yuqin Li,Pengzhou Li et al.
Hua Fu et al.
Background: Obesity and associated metabolic disorders remain major public health challenges worldwide. The regulation of lipid synthesis represents a promising therapeutic target, yet the precise mechanisms remain elusiv...
A multi-targeted therapeutic strategy for triple-negative breast cancer: the tumor-targeting peptide p28 enhances chemotherapy, induces apoptosis, crosses the blood-brain barrier, and suppresses metastasis [0.03%]
Haniyeh Abuei,Pei Pei Chong,Mohammad Hossein Malekzadeh et al.
Haniyeh Abuei et al.
Triple-negative breast cancer (TNBC) is an aggressive and molecularly heterogeneous subtype of breast cancer characterized by limited targeted treatment options, frequent chemoresistance, and a strong propensity for metastasis, particularly...
QD394 induces ferroptosis and suppresses the proliferation of colorectal cancer via the SP1/JNK pathway [0.03%]
Ruixue Zhang,Haiyan Quan,Wenjing Xiao et al.
Ruixue Zhang et al.
Lipid peroxidation triggers ferroptosis, a type of regulated cell death that is iron-dependent. Owing to its important role in tumor suppression, ferroptosis represents an extremely promising therapeutic target for cancer. QD394, a quinazol...
The CHI3L1 protein plays role as a protecting factor against autophagy in glioblastoma cells [0.03%]
Agnieszka Rusak,Marzena Janiszewska,Maciej Raczkowski et al.
Agnieszka Rusak et al.
The CHI3L1 protein supports various types of cancer progression and metastasis, where the background players were the upregulation of angiogenesis and microenvironment modulation. In glioblastoma (GB), high vascularisation is a key feature ...
Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer [0.03%]
塞来昔布通过协同靶向COX-2/NF-κB和PI3K/AKT/mTOR途径增强ribociclib诱导的激素受体阳性/HER2阴性乳腺癌凋亡和抗肿瘤活性
Sanghee Han,Hail Kim,Minji Choi et al.
Sanghee Han et al.
Necroptosis in pancreatic cancer: Molecular mechanisms and therapeutic implications [0.03%]
胰腺癌中的坏死性凋亡：分子机制及治疗意义
Yu-Jie Fan,Wei-Jia Liu,Chang Liu et al.
Yu-Jie Fan et al.
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer due to its strong resistance to chemotherapeutic agents that induce apoptosis. As conventional treatments gradually lose their effectiveness over time, necroptosis has b...
Tumor suppressor candidate 1 (TUSC1) drives oxidative phosphorylation and tumor cell death in colorectal cancer [0.03%]
肿瘤抑制候选基因1(TUSC1)驱动结直肠癌的氧化磷酸化和肿瘤细胞死亡
Janvie Manhas,Ruchi Bhardwaj,Sagar Tyagi et al.
Janvie Manhas et al.
Tumor Suppressor Candidate-1 (TUSC1), located at chromosome 9p21.2, resides within a region frequently deleted in human malignancies, yet its role in colorectal cancer (CRC) remains undefined. We investigated TUSC1 expression and function u...
The ATG14: multi-layer autophagy control and an emerging therapeutic target in cancer [0.03%]
ATG14：抗肿瘤的多层自噬调控因子及新的治疗靶点
Wenbo Wang,Chujuan Yu,Fulin Sun et al.
Wenbo Wang et al.
ATG14 (ATG14L/Barkor) is the autophagy-specific subunit of class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) and functions as a pivotal node linking autophagosome formation to autophagosome-lysosome fusion. Functionally, ATG14 r...