Klotho Attenuates Glucocorticoid-Induced Osteoblast Cytotoxicity Via Wnt Signaling Pathway Modulation [0.03%]
生命素通过调节Wnt信号通路减弱糖皮质激素诱导的成骨细胞细胞毒性
Sen Wang,Miao He,Xiao Liang et al.
Sen Wang et al.
Glucocorticoids are commonly prescribed in clinical settings; however, their prolonged use at high doses can adversely affect human health. One significant complication following glucocorticoid therapy is glucocorticoid-induced osteoporosis...
CRISPR-Cas and Infectious Diseases: A Decade of Translational Advances in Molecular Biotechnology [0.03%]
CRISPR-Cas与传染病：分子生物技术十年的转化进展
Kannan Mayuri,Konda Mani Saravanan,Chaitanya Sree Somala et al.
Kannan Mayuri et al.
CRISPR-Cas systems have emerged as a versatile tool for diagnosing, treating, and preventing infectious diseases. This review highlights translational advancements in CRISPR-Cas-based applications, concentrating on the past decades in diagn...
Circular RNA Circ_0020236 Inhibits Hepatocellular Carcinoma Cell Proliferation and Migration Through Modulating the MiR-1825/IKBKB Axis [0.03%]
Circular RNA Circ_0020236通过调节MiR-1825 / IKBKB轴抑制肝癌细胞增殖和迁移
Jing Liu,Bing Sun,Peng Cao et al.
Jing Liu et al.
Hepatocellular carcinoma (HCC) is one of the most metastatic and aggressive malignancies. Circular RNAs (circRNAs) are associated with the pathogenesis and prognosis of HCC. This study aimed to explore the role of circ_0020236 in HCC progre...
The Sonic Hedgehog Pathway is Activated in Cushing's Disease with USP8 Mutations [0.03%]
USP8突变的库欣病中活化Sonic Hedgehog信号途径
Shan Huang,Yihua Xu,Xiang Zhou et al.
Shan Huang et al.
Cushing's disease (CD) is a neuroendocrine disorder characterized by excessive adrenocorticotropic hormone (ACTH) secretion from pituitary adenomas, closely associated with ubiquitin-specific protease 8 (USP8) mutations. This study aimed to...
Saikosaponin D Attenuates Postherpetic Neuralgia and Reduces Inflammation by Regulating Gut Microbiota in a Rodent Model [0.03%]
补骨脂异黄酮通过调节肠道微生物治疗带状疱疹后神经痛
Shaokang Cai,Chunhua Sun,Qun Wu et al.
Shaokang Cai et al.
Saikosaponin D (SSD) is a triterpenoid saponin derived from Bupleuri Radix and has therapeutic potential for the treatment of neuropathic pain. This study investigates the roles and underlying mechanisms of SSD in cellular and mouse models ...
The Complete Mitochondrial Genome of a Newly Recorded Chinese Species of Diglyphus sabulosus (Hymenoptera: Eulophidae) and Insights into Its Phylogenetic Position [0.03%]
中国新记录种Diglyphus sabulosus的线粒体全基因组及其系统发育地位的初步研究
Lu-Chao Fang,Zhi-Qiang Ge,Ou-Yan Xi et al.
Lu-Chao Fang et al.
Diglyphus Walker, 1844 is an economically important genus which many species acting as biocontrol agents against agromyzid leafminer pests, but there is a lack of mitogenomic data on the evolutionary relationships within this genus, hinderi...
Evolutionary and Structural Insights into Proline Metabolism Genes Associated with Salt Resilience in Mango [0.03%]
与芒果耐盐性相关的脯氨酸代谢基因的进化及结构洞察
Laxmi Rastogi,Anju Bajpai,Sumit K Soni et al.
Laxmi Rastogi et al.
Identification of Key Genes Related to SUMOylation and Potassium Channels and Their Mechanism of Influence on Pulmonary Arterial Hypertension [0.03%]
与SUMO化和钾通道相关的关键基因鉴定及其对肺动脉高压影响的机制研究
Lingyun Gao,Wei Huang,Qianqian Wang et al.
Lingyun Gao et al.
CD27 Neutralization Attenuates Rheumatoid Arthritis by Suppressing [0.03%]
CD27中和通过抑制效应T细胞功能缓解类风湿性关节炎
Anghan Lu,Luqiao Pu,Yadan Tian et al.
Anghan Lu et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and destruction. Identifying novel therapeutic targets is crucial for improving RA treatment. This study aimed to identify immune-related biomarke...