Association of miR-146a/b and miR-181a with Chronic Obstructive Pulmonary Disease [0.03%]
miR-146a/b和miR-181a与慢性阻塞性肺疾病的关系研究
Sanaz Abbaspour-Aghdam,Amir Valizadeh,Khadijeh Pouya et al.
Sanaz Abbaspour-Aghdam et al.
miRNAs play critical roles in regulating inflammatory responses in chronic obstructive pulmonary disease (COPD). This study investigated the expression patterns of miR-146a/b and miR-181a, along with associated inflammatory mediators, in CO...
ANGPTL1 Inhibits the Growth, Migration, and Angiogenesis of Gastric Cancer Cells by Downregulating VEGFA Expression [0.03%]
血管生成素-like蛋白1通过下调血管内皮生长因子A的表达抑制胃癌细胞的生长、迁移和血管生成
Lingli Jin,Guangxin Lu,Rui Shang et al.
Lingli Jin et al.
Gastric cancer (GC) remains one of the most common malignant tumors worldwide, with high incidence and mortality rates. Angiopoietin-like protein 1 (ANGPTL1), a member of the ANGPTL family, is known to function as an anti-angiogenic factor ...
LncRNA CCAT1/miR-490-3p/VDAC1 Axis Promotes Colorectal Cancer Progression by Activating Glycolysis [0.03%]
长链非编码RNA CCAT1通过激活糖酵解促进结直肠癌发展的miR-490-3p/VDAC1轴作用机制研究
Yongli Ge,Qi Liu,Lijuan Zhao et al.
Yongli Ge et al.
To elucidate the molecular mechanism by which long non-coding RNA CCAT1 (LncRNA CCAT1) promotes colorectal cancer (CRC) progression via regulation of microRNA miR-490-3p and Voltage-Dependent Anion Channel 1 (VDAC1), thereby activating glyc...
MiR-146b-5p/ERBB4 Axis Drives LPS-induced Acute Kidney Injury by Modulating NF-κB/p65 [0.03%]
MiR-146b-5p/ERBB4轴通过调节NF-κB/p65诱导LPS引起的急性肾损伤
Dazhuang Sun,Limin Wang,Shoulei Liu
Dazhuang Sun
We aimed to explore the role of miR-146b-5p in lipopolysaccharide (LPS)-induced acute kidney injury. C57BL/6N mice were intraperitoneally injected with LPS to establish an acute kidney injury model, and the effects of miR-146b-5p inhibition...
The Role of Small Segmental Duplications in Generating Identical Isoforms Through Alternative Splicing Sites [0.03%]
小型片段重复通过可变剪切位点在生成相同异构体中的作用
Ulkar Huseynova Mustafayeva,Sevda Babayeva,Orkhan Mustafayev et al.
Ulkar Huseynova Mustafayeva et al.
Alternative splicing plays a crucial role in expanding proteomic diversity but can also generate identical isoforms under certain conditions. While mutually exclusive splicing of tandem exons has occasionally been reported to produce identi...
Bacillus spp. Mediated Growth Enhancement and Antioxidative Defence Activation in Peppermint (Mentha piperita L.) [0.03%]
枯草芽孢杆菌促进薄荷生长及抗氧化防御响应研究
Vagmi Singh,Shivani Chandra,Ram Kishor et al.
Vagmi Singh et al.
Peppermint (Mentha piperita L.) is a valuable medicinal and aromatic herb cultivated globally for its essential oil, prized for its therapeutic and flavouring properties. The productivity and essential oil quality of peppermint is strongly ...
A User-Friendly Protocol for Microinjection into Teleost Embryos to Study Gene Function [0.03%]
一种用于研究基因功能的鱼类胚胎显微注射的用户友好型方案.protocol
Alicia Mendoza,Isabella Simon,Sharmin Hasan
Alicia Mendoza
Zebrafish (Danio rerio) and medaka (Oryzias latipes) are popular teleost models used in developmental biology and functional genomics. To achieve high-quality and reproducible microinjections, it is essential to have robust protocols for br...
Genetic Diversity of BK Polyomavirus Among Renal Transplant Recipients in Yunnan, China [0.03%]
中国云南肾移植受者BK polyomavirus基因多样性研究
Dan Pu,Yongsheng Pan,Li Ming et al.
Dan Pu et al.
BK polyomavirus (BKV) infection, a common complication following kidney transplantation, can lead to BKV-associated nephropathy (BKVN). Molecular genetic studies have classified BKV into four genotypes (I-IV); however, comprehensive molecul...
The LINC00920/miR-6834-3p/CPN1 Axis Modulates Immune Dysregulation in Sepsis-Associated Acute Kidney Injury and Serves as a Diagnostic Biomarker [0.03%]
LINC00920/miR-6834-3p/CPN1轴调控脓毒症相关急性肾损伤中的免疫紊乱并作为诊断生物标志物
Yang Wang,Jiuqiang Zhang,Kunbin Liu et al.
Yang Wang et al.
Sepsis-associated acute kidney injury (SA-AKI) is a serious complication with high mortality and lacks effective diagnostic and treatment strategies. This study aims to investigate the role of the LINC00920/miR-6834-3p/CPN1 axis in SA-AKI a...
Association Between Ticagrelor and Glucose Homeostasis Regulation: Insights from Genetic and Transcriptomic Analyses [0.03%]
替卡格雷与糖类稳态调节的关联：来自遗传学和转录组学分析的新见解
Zhipeng Xie,Heshuo Ma,Yingjian Liu et al.
Zhipeng Xie et al.
Emerging evidence has demonstrated the additional therapeutic benefits of ticagrelor in acute coronary syndrome (ACS) patients with diabetes. However, the underlying mechanisms of this association remain elusive. Mendelian randomization (MR...