COVID-19 as a Modifier of Genetically Determined Coagulation Phenotype: Implications for Precision Risk Stratification After Infection [0.03%]
新冠肺炎感染对遗传决定的凝血表型的影响：精确风险分层的含义
Oleg Alexandrovich Perevezentsev,Ilgar Salekh Mamedov,Dmitry Vladimirovich Burtsev
Oleg Alexandrovich Perevezentsev
Persistent endothelial dysfunction and coagulation abnormalities are increasingly recognized as central components of post-COVID syndrome. However, substantial interindividual variability in long-term coagulation biomarkers suggests the pre...
Promoter Methylation of HOXA5 and NDRG2 in Multiple Myeloma Patients with Renal Impairment [0.03%]
肾功能受损的多发性骨髓瘤患者中HOXA5和NDRG2启动子甲基化状况研究
Riham Abdel-Hamid Haroun,Dina Samir Elsaid,Mona A Al-Dosoky et al.
Riham Abdel-Hamid Haroun et al.
Renal impairment (RI) is frequently caused by multiple myeloma (MM), which makes clinical care more difficult if renal function deteriorates or renal failure develops. Thus, in this investigation, we looked at the relationship between HOXA5...
Hedyotis diffusa Willd-Scutellaria barbata D.Don Suppresses Colorectal Cancer Liver Metastasis by Targeting hsa_circ_0039933-Mediated Epithelial-Mesenchymal Transition [0.03%]
半边莲-夏枯草通过靶向环状RNA circ_0039933抑制上皮间质转化从而抑制结直肠癌肝转移
Shanmin Yuan,Sha Li,Cong Chen
Shanmin Yuan
Colorectal cancer (CRC) liver metastasis remains a major cause of mortality, necessitating novel therapeutic strategies. Hedyotis diffusa Willd -Scutellaria barbata D.Don (HD-SB), a traditional Chinese herbal formulation, has demonstrated a...
Lactate as a Signaling Molecule in the Tumor Microenvironment: Implications for Cancer Progression [0.03%]
乳酸作为肿瘤微环境中的信号分子及其对癌症进展的影响
Shireen S Kamil,Alaa Shahid Jassim Al-Bdery,Ali H Al-Marzoqi et al.
Shireen S Kamil et al.
Aerobic glycolysis is a process commonly utilized by tumor cells to produce excessive lactate, acidification of the extracellular milieu and promoting tumor progression. Lactate plays its roles as a metabolic intermediate and as a signaling...
Epirubicin-Induced Upregulation of miR-143-3p and miR-145 Enhances Cytotoxicity in MCF-7, MDA-MB-231, and BT-474 Breast Cancer Cell Lines [0.03%]
表柔比星通过上调miR-143-3p和miR-145增强MCF-7，MDA-MB-231及BT-474乳腺癌细胞系的毒性作用
Morteza Rajabi,Niki Ghambari Mohammadi,Mahsa Mombeyni et al.
Morteza Rajabi et al.
Drug resistance poses a significant challenge to effective breast cancer chemotherapy. This study investigated the regulatory effects of Epirubicin on miR-143-3p and miR-145 expression in BT-474, MCF-7, and MDA-MB-231 breast cancer cell lin...
Vitamin D Supplementation Modulates Base Excision Repair (BER) Machinery in Systemic Sclerosis: A Prospective Longitudinal Study [0.03%]
维生素D补充调节系统性硬化病中碱基切除修复机制的前瞻性队列研究
Nazli Ecem Dal-Bekar,Ali Birdogan,Gul Huray Islekel et al.
Nazli Ecem Dal-Bekar et al.
Systemic sclerosis (SSc) is a chronic, autoimmune, fibrotic disorder involving immune dysregulation, vascular abnormalities and progressive fibrosis. Although oxidative stress and defective DNA repair have been implicated in its pathogenesi...
Genomic and Molecular Interaction Analysis of NodD1 in a Novel Bradyrhizobium yuanmingense sp. B64 Isolate for Nodulation and Symbiosis of Legume Plants [0.03%]
固氮根瘤菌属元明菌株B64结瘤和共生的新型NodD1分子互作及基因组分析
Aura Aslan,Rumella Simarmata,Dwi Santosa et al.
Aura Aslan et al.
Rhizobial bacteria are known for their ability to fix nitrogen for leguminous plants and their essential function for sustainable agriculture. This study characterizes the taxonomic status and functional potential of the Bradyrhizobium B64 ...
Carbapenem-Resistant Acinetobacter baumannii: Resistance, Virulence, and Possible Dissemination Between Different Hospitals in Western Iran [0.03%]
伊朗西部耐碳青霉烯类鲍曼不动杆菌的耐药性、毒力及可能在不同医院间的播散
Mobina Niknian,Kambiz Feizi,Bita Bakhshi et al.
Mobina Niknian et al.
The capacity for biofilm formation, along with the acquisition of antimicrobial resistance, could be the primary factors enhancing the persistence and spread of Acinetobacter baumannii (AB). We aimed to identify the trends in molecular epid...
FTO Deficiency Inhibits Vascular Endothelial Cell Apoptosis and Improved Mitophagy in Obesity-Related Hypertension by Enhancing NDRG1 m6A Methylation [0.03%]
FTO缺陷通过增强NDRG1 mRNA甲基化抑制肥胖相关高血压血管内皮细胞凋亡及改善线粒体自噬作用
Qinglei Gan,Na Yang
Qinglei Gan
Vascular endothelial dysfunction contributes to obesity-related hypertension, yet its mechanisms remain unclear. This study examined the role of N6-methyladenosine (m6A) in this process using in vivo and in vitro models. C57BL/6J mice fed a...
Circular RNA hsa_circ_0002473 Boosts Gastric Cancer Progression via the miR-873-5p/TEAD1 Axis [0.03%]
circRNA hsa_circ_0002473通过miR-873-5p/TEAD1轴促进胃癌进展
Min Wang,Zhouying Wu,Ruiying Tong et al.
Min Wang et al.
Circular RNAs (circRNAs) display cancer-specific expression profiles associated with the prevalence and fatality rates of gastric cancer (GC). Although the functions of certain circRNAs in GC advancement have been clarified, a recently iden...