Decoding Genetic Risk Factors in Recurrent Pregnancy Loss: An Integrative Chromosomal and Bioinformatics Approach [0.03%]
复发性妊娠丢失的遗传危险因素解码：整合染色体和生物信息学方法
Shivani Mishra,Ashish Ashish,Sangeeta Rai et al.
Shivani Mishra et al.
Recurrent pregnancy loss (RPL) is characterized by two or more consecutive pregnancy losses, often associated with genetic, immunological, endocrine, and anatomical abnormalities. Among these, chromosomal abnormalities, including aneuploidi...
Chromosome-Level Genome Assembly of the Sea Urchin Glyptocidaris crenularis and Sex Chromosome Identification [0.03%]
海胆（甘氏钝泽海胆）染色体水平基因组组装及性染色体识别
Quanchao Wang,Wanlong Sun,Yufeng Zhai et al.
Quanchao Wang et al.
The economic importance of the sea urchin Glyptocidaris crenularis drives the need to elucidate the genetic mechanisms controlling its sex differentiation and development, a key step for enabling targeted genetic improvement. This study pre...
Genetic Diversity and Population Structure of 72 Turkish Ficus carica (L.) Genotypes Assessed Using SCoT Markers [0.03%]
基于SCoT标记的土耳其72份无花果（Ficus carica L.）种质遗传多样性及亲缘关系分析
Meliha Feryal Sarıkaya,Muhammad Azhar Nadeem,Sarmad Ali Qureshi et al.
Meliha Feryal Sarıkaya et al.
Ficus carica L. is an economically important fruit crop widely cultivated in the Mediterranean region. In this study, genetic diversity and population structure were investigated in 72 F. carica genotypes collected from the Derecik and Çuk...
A Splice-Site Variant in ACY1 Associated with Congenital Hearing Loss: Clinical, Biochemical, and Zebrafish Functional Evidence [0.03%]
ACY1内含子变异导致先天性耳聋的临床、生化及斑马鱼功能证据
Sha Yu,Zhenmin Xu,Huijun Wang et al.
Sha Yu et al.
Variants in the aminoacylase 1 (ACY1) gene are associated with diverse clinical phenotypes, but their roles in hearing loss remain unclear. This study aimed to investigate the potential role of ACY1 in hearing loss. Exome sequencing was per...
Replication Study of ENPP1 Variants and Haplotypes Associated with Severe Obesity in a Greek Adult Population [0.03%]
希腊成年人群中ENPP1基因变异和与重度肥胖相关的单倍型的重复实验研究
Konstantinos Rouskas,David Meyre,Stephane Lobbens et al.
Konstantinos Rouskas et al.
The ENPP1 (Ectonucleotide pyrophosphatase/phosphodiesterase 1) gene, encoding a protein that negatively modulates insulin receptor activation, remains relatively understudied in obesity genetics. K121Q (rs1044498; chr6:132,172,368: A > C) a...
Exercise-Driven NRF2 Activation as a Systemic Neuroprotective Strategy: Integrating Redox Biology, Muscle-Brain Crosstalk, and Therapeutic Targeting in Neurodegeneration [0.03%]
运动驱动的NRF2活化作为系统性神经保护策略：整合氧化还原生物学、肌肉-大脑交叉对话和神经退行性疾病治疗靶点
Pichao Deng,Wei Deng,Linyao Wang et al.
Pichao Deng et al.
Neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, are characterized by progressive neuronal dysfunction and loss. Recent evidence highlights the importance of the nuclear factor erythroid 2-related f...
Splicing Alterations Associated with Multiple Homozygous TNXB Variants in a Patient with Suspected Classical-Like Ehlers-Danlos Syndrome [0.03%]
疑似经典型类先天性皮肤松垂病患者的TNXB变异及剪接改变
Bunta Imanaka,Yuiko Hasegawa,Kazumi Kawato et al.
Bunta Imanaka et al.
Ehlers-Danlos syndrome (EDS) comprises a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Classical-like EDS (clEDS) is typically associated wi...
Comparative Analysis of Stemness and Differentiation Gene Expression in Mesenchymal Stem Cells from Permanent and Deciduous Teeth: An In Vitro Study to Evaluate Implications for Regenerative Dentistry [0.03%]
恒牙和乳牙间充质干细胞干性及分化相关基因表达的比较分析：体外实验评估其在再生齿科学中的意义
Seyed Amir Abas Noorbakhsh,Fatemeh Pourmohammadi-Nejad,Ali Pirsadeghi et al.
Seyed Amir Abas Noorbakhsh et al.
Dental pulp is a valuable source of mesenchymal stem cells (MSCs), offering significant promise for cell therapy and regenerative medicine, particularly in treating oral and dental conditions. For clinical translation, understanding which d...
Fisetin Modulates Chemoresistance-Associated miR-21, miR-181a, miR-203, miR-101 and miR-381 in Capecitabine-Resistant HT29 Colorectal Cancer Cells [0.03%]
山柰酚调节卡培他滨耐药HT29结直肠癌细胞中与化疗抗性相关的miR-21、miR-181a、miR-203、miR-101和miR-381
Zehra Kanlı,İrem Peker Eyüboğlu,Kazim Yalcin Arga et al.
Zehra Kanlı et al.
Capecitabine is a key component of colorectal cancer (CRC) chemotherapy; however, acquired resistance markedly limits its efficacy. MicroRNAs (miRNAs) are central regulators of drug response, and the flavonoid fisetin has been reported to e...
HILPDA, Regulated by WTAP in an m6A-Dependent Manner, Enhances Osteosarcoma Development by Inhibiting Ferroptosis and Promoting Glycolysis [0.03%]
由WTAP通过m6A依赖方式调控的HILPDA通过抑制铁死亡和促进糖酵解增强骨肉瘤发生发展
Yong Jing,Guoyong Zhang,Chenghui Sun et al.
Yong Jing et al.
Osteosarcoma (OS) is the most common primary malignant bone cancer. Hypoxia-inducible lipid droplet-associated protein (HILPDA) promotes tumor growth, migration, and ferroptosis resistance in OS. However, the oncogenic mechanisms of HILPDA ...