Dmitrii Sergeevich Bug,Dariia Andreevna Kuzovenkova,Artem Valerievich Tishkov et al.
Dmitrii Sergeevich Bug et al.
Deciphering the evolutionary history of genes is foundational for biomedical research, enabling the identification of compensatory mutations in disease-associated genes and the selection of evolutionarily relevant model organisms. However, ...
Influence of Genetic and Epigenetic Factors on Periodontitis Susceptibility and Treatment Outcomes [0.03%]
遗传和表观遗传因素对牙周炎易感性和治疗效果的影响
Maryam Jalili Sadrabad,Parham Mohammadian Semnani,Farid Ghadyani et al.
Maryam Jalili Sadrabad et al.
Periodontitis (PD) is a complex inflammatory condition driven by the interplay of microbial, genetic, epigenetic, and environmental factors. While bacterial biofilms are regarded as the primary cause, growing evidence underscores the signif...
Mitogenome and Phylogeny of the Hairy Puffer Pao baileyi (Sontirat 1985) [0.03%]
巴氏毛刺鱼线粒体基因组及系统发育地位研究
Wei Hu,Xiao-Die Chen,Xiao Ma et al.
Wei Hu et al.
The mitogenomics of Pao baileyi (Sontirat 1985), a tropical pufferfish with ornamental and research value, remain unreported. To understand its molecular characteristics and enrich mitogenome data for Tetraodontidae fish, in this study, we ...
β-Eudesmol Alleviates Inflammatory Injury in Septic Cardiomyopathy Through Enhancing GSK3B Activity to Inhibiting IL-17-Mediated Chemokine Expression [0.03%]
β-艾术醇通过增强GSK3B活性抑制IL-17介导的细胞因子表达从而缓解脓毒症心肌炎病理损伤
Sihua Jiang,Zhuoqing Dai,Tingting Pang et al.
Sihua Jiang et al.
Septic cardiomyopathy (SCM) is heart failure caused by sepsis and often causes an excessive inflammatory response. As a natural sesquiterpene alcohol, the anti-inflammatory properties of β-Eudesmol have been confirmed in various inflammato...
Sexually Dimorphic RNA Helicase DDX3Y, But Not DDX3X, Plays a Potential Tumor-Suppressive Role in Colorectal Carcinogenesis in Males [0.03%]
性别二态性RNA解旋酶DDX3Y而非DDX3X在男性结直肠癌发生发展中发挥潜在的抑癌作用
Suresh Govatati,Sravanthi Malempati,Roy Karnati et al.
Suresh Govatati et al.
Beyond its role in sex determination, the Y chromosome contains genes that regulate transcription, translation, and protein stability, thereby contributing to the pathogenesis of various male-specific diseases, including cancer. Although se...
Identification of a Novel Slow-Gray STX17 Lineage in Japanese Thoroughbreds via a Multi-tiered Copy Number Analysis Workflow [0.03%]
通过多级拷贝数分析工作流程在日本赛马中鉴定出一种新的STX17慢灰系变异体
Koki Kawate,Risako Furukawa,Mio Kikuchi et al.
Koki Kawate et al.
Gray is a dominant coat color phenotype in horses caused by a ~ 4.6 kb tandem triplication within intron 6 of syntaxin 17 (STX17). The copy number variation (CNV) of the duplicated segment influences the graying rate. The rare G2 allele (CN...
Expression of Transforming Growth Factor Beta 1 in Lung Adenocarcinoma and Its Relationship with Circulating Tumour Cells [0.03%]
转化生长因子β1在肺腺癌中的表达及其与循环肿瘤细胞的关系
Ning Chen,Duo-Jun Qiu,Jian-Zhu Yang et al.
Ning Chen et al.
To investigate the relationship between the expression of transforming growth factor beta 1 (TGF-β1), epithelial-mesenchymal transition (EMT)-related proteins, circulating tumour cells (CTCs) positivity rate and tumour differentiation degr...
The Role of Exercise in Regulating Histone Modifications and Non-coding RNAs in Muscle Aging and Sarcopenia [0.03%]
运动在肌肉衰老和肌少症中调节组蛋白修饰和非编码RNA的作用
Junli Wang,Junhua Li
Junli Wang
Sarcopenia, the progressive loss of skeletal muscle mass and function with age, is a major contributor to frailty and decreased quality of life in older adults. While physical exercise remains the most effective intervention, its molecular ...
VALD-3 Induces GSDME-Dependent Pyroptosis via ROS/JNK/Bax Pathway in Triple-Negative Breast Cancer Cells [0.03%]
VALD-3通过ROS/JNK/Bax途径在三阴性乳腺癌细胞中诱导GSDME依赖性焦亡
Xuhui Zhao,Xuhong Pan,Weijie Ma et al.
Xuhui Zhao et al.
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer, known for its high malignancy, elevated risk of recurrence and metastasis, and limited therapeutic options, resulting in the poorest prognosis among...
Correlation Between SGK1 Expression Level and Multiple Myeloma Progression After Autologous Hematopoietic Stem Cell Transplantation [0.03%]
SGK1表达量与自体造血干细胞移植后多发性骨髓瘤进展的相关性研究
Ting Fan,Caili Guo,Ying Zhang et al.
Ting Fan et al.
To explore the correlation between serum and glucocorticoid inducible kinase-1 (SGK1) expression levels and the multiple myeloma (MM) progression in patients after autologous stem cell transplantation (ASCT). A total of 100 MM patients who ...