MC4R methylation and antipsychotic-related metabolic changes in early psychosis: findings from two prospective cohorts [0.03%]
早期精神病患者中MC4R甲基化与抗精神病药物相关代谢变化：来自两项前瞻性队列研究的发现
C M Loureiro,H A Fachim,G C Bissoli et al.
C M Loureiro et al.
Metabolic side effects represent a major long-term concern in antipsychotic (AP)-treated early psychosis. We evaluated the weight gain and changes in related metabolic parameters in patients followed up for 12 months. We also explored DNA m...
The association between daily reports of psychotic experiences and life worthiness in early risk stages for psychosis and across gender [0.03%]
全面评估心理健康状况：阐述妄想体验与生活意义的关系性别差异研究
Merel Karlijn Muller,Esdras Raposo de Almeida,Sara van der Tuin et al.
Merel Karlijn Muller et al.
Aim: Explore the temporal and contemporaneous associations between daily reports of psychotic experiences (PEs) and life worthiness (LW) in individuals in early risk stages for psychosis, and to examine whether these asso...
Novel positive allosteric modulators of alpha 5 subunit-containing GABAA receptors (α5-GABAARs) reverse the hyperdopaminergic state in a neurodevelopmental model of schizophrenia [0.03%]
新型α5亚单位含组胺A受体正向别构调节剂逆转精神分裂症神经发育模型中的高多巴胺状态
Daniela L Uliana,Mariana O Popa,Michael Paradowski et al.
Daniela L Uliana et al.
Dysfunction in the GABAergic system has been described in schizophrenia, including decreased expression of α5 subunit-containing GABAA receptors (α5-GABAARs) in patients with schizophrenia. This study explores the therapeutic potential of...
Improved quality of life with semaglutide in schizophrenia: Secondary analyses from a randomized controlled trial [0.03%]
利司那肽改善精神分裂症患者生活质量：一项随机对照试验的次要分析结果
N Uhrenholt,A Ganeshalingam,S Arnfred et al.
N Uhrenholt et al.
Background: People with schizophrenia experience markedly reduced health-related quality of life (QoL), partly driven by obesity and metabolic dysregulation. Glucagon-like peptide-1 receptor agonists such as semaglutide i...
G Muntané,A Valle,P Ramon-Cañellas et al.
G Muntané et al.
Background: Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a complex genetic architecture influenced by both common and rare variants. Disease age at onset (AAO) is a critical clinical feature, with earlie...
Radiomics-based prediction of early antipsychotic treatment response for first-episode schizophrenia [0.03%]
基于影像组学预测首发精神分裂症早期抗精神病治疗反应
Mengdi Jin,Haixin Li,Lijuan Yan et al.
Mengdi Jin et al.
Background: This study aims to develop and validate cranial CT-based radiomics models for predicting early antipsychotic response in first-episode schizophrenia (SCZ). ...
Chicken or the egg: The relationship between cognitive deficits and negative symptoms in first episode psychosis [0.03%]
鸡与蛋：首次精神病发作时的认知缺陷和负面症状之间的关系
Christy Au-Yeung,N Keita Christophe,Katie M Lavigne et al.
Christy Au-Yeung et al.
Background: Cognitive impairments and negative symptoms (NS) represent an unmet therapeutic need in psychotic disorders. Both NS and cognitive impairments, are key predictors of functioning. Both also appear during the il...
Asociality in schizophrenia: A review of historical foundations, measures, mechanisms, and treatments [0.03%]
精神分裂症离群索居现象的历史根源、衡量方式、作用机制及治疗方法综述
Katherine Toda-Thorne,Lauren Luther
Katherine Toda-Thorne
Asociality - diminished desire for social connection and reduced initiation of social interaction - has profound effects on a person's occupational and interpersonal functioning. Although asociality has long been described in those with sch...
Contributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk [0.03%]
前驱期精神病认知功能障碍的皮层厚度及表面积相关研究
Ryan M Guest,Jean Addington,Carrie E Bearden et al.
Ryan M Guest et al.
Cognitive deficits in schizophrenia are detectable at the onset of illness and during the preceding prodromal period. Additionally, adolescents and young adults at clinical high risk for psychosis (CHR-P) demonstrate cognitive impairment re...
Hippocampus in the symptom architecture of schizophrenia spectrum disorders: A network analysis approach [0.03%]
从网络分析的角度探究精神分裂症光谱障碍的症状结构中的海马体作用
Stefan Fritze,Dilsa Cemre Akkoc Altinok,Sebastian Volkmer et al.
Stefan Fritze et al.
Background: Hippocampal volume reductions are among the most robust neuroanatomical findings in schizophrenia spectrum disorders (SSD). However, how these structural alterations relate to core functional domains such as c...